| Project/Area Number |
26670175
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
YASUI WATARU 広島大学, 医歯薬保健学研究院, 教授 (40191118)
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| Co-Investigator(Renkei-kenkyūsha) |
OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エクソソーム / ncRNA / 超保存領域（T-UCR） / 胃癌 / 前立腺癌 / 診断・治療展開 |
|---|
| Outline of Final Research Achievements |
By the analysis of Transcribed ultraconserved region (T-UCR) transcripts, the levels of many T-UCRs are found to be altered in cancers. Among those, Uc.416+A,up-regulated in cancer, was negatively regulated by miR-153 and participated in cell growth through IGFBP6 and HOXB5/B6. Uc.416+A was secreted from cancer cells and high levels were detected in the sera of cancer patients. Application to liquid biopsy system is expected.
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