Studies on pathogenesis of failure of vascular integrity and fate in pathological vascular remodeling.

• Project/Area Number: 26670177
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: Nakagawa Kazunori 九州大学, 医学研究院, 講師 (50217668)
• Co-Investigator(Kenkyū-buntansha): 鬼丸 満穂 九州大学, 医学研究院, 助教 (00380626)
• Co-Investigator(Renkei-kenkyūsha): SUEISHI KATSUO 国立病院機構福岡東医療センター, 研究教育部長 (70108710)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 病理学 / 循環器 / 動脈硬化 / Ｄアスパラギン酸 / 石灰化 / 血管リモデリング / 終末糖化産物 / 血管平滑筋細胞

Outline of Final Research Achievements

Early stages of atherosclerosis develop not by SMC migration and proliferation, but by dispersion of intimal SMCs, that were caused by the macrophage infiltration and the lipid pool formation without undergoing significant proliferation or death. Formation of non-enzymatic chemical products (D-aspartic acid or Advanced glycation end products(AGEs)) in intima would associate with matrix degradation or calcification. As results, accumulation of these errors in vascular wall pull the trigger of pathogenesis, and affects the advanced fate of atherosclerosis.

Research Products

• [Journal Article] 急性大動脈解離の病理 (2016)
  • Author(s): 中島 豊、中川和憲
  • Journal Title: カレントテラピー Volume: 34(9)
• [Journal Article] Impact of synchrotron radiation-based X-ray phase-contrast tomography on understanding various cardiovascular surgical pathologies. (2015)
  • Author(s): Tsukube T, Yagi N, Hoshino M, Nakashima Y, Nakagawa K, Okita Y
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 63(10) Issue: 10 Pages: 590-592
  • DOI: 10.1007/s11748-015-0565-4
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 大動脈解離の発生機序に関する研究 - 位相差X線CT法および超音波検査法による大動脈壁微細構造の検討 (2016)
  • Author(s): 築部卓郎, 八木直人, 星野真人, 中島 豊, 中川 和憲, 原口知則, 岡田泰司, 中井史, 大北 裕
  • Organizer: 第69回日本胸部外科学会定期学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2016-09-28
• [Presentation] Impact of synchrotron radiation based phase-contrast X-ray CT findings on understanding onset of acute aortic dissection. (2015)
  • Author(s): Tsukube T, Yagi N, Hoshino M, Nakashima Y, Nakagawa K, Okada Y, Haraguchi T, Yoshida M, Mukohara N, Kozawa S, Ogawa K, Okita Y.
  • Organizer: American Association fot Thotacic Surgery, Aortic Symposium Workshop2015
  • Place of Presentation: Kobe
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] ヒトの冠状動脈硬化における前粥腫病変(preatheroma, intermediate lesion)の発生病理 (2014)
  • Author(s): 中川 和憲, 中島豊
  • Organizer: 第２１回 九州血液血管研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-08
• [Presentation] Pathogenesis of intermediate lesion of human coronary atherosclerosis: Lipid pool formation without necrosis and dispersion of intimal smooth muscle cells. (2014)
  • Author(s): Nakagawa K, Hiroshi Fujii H, Nakashima Y.
  • Organizer: The 82nd Annual Congress of The European Atherosclerosis Society
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2014-06-02
• [Book] 大動脈解離―診断と治療のStandard (2016)
  • Author(s): 中島豊、中川和憲
  • Total Pages: 192
  • Publisher: 中外医学社