Analysis for microRNA in osteo- and chondro-sarcomas

• Project/Area Number: 26670179
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Iwate Medical University
• Principal Investigator: Satoh Takashi 岩手医科大学, 医学部, 教授 (20170756)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 転移 / 骨軟部腫瘍 / miRNA / lincRNA / ARF6 / polycome / PC2 / ChIP-sequence

Outline of Final Research Achievements

Advances in treatment modalities for osteo-, and chondro-sarcomas (OCSs)contributes to their disease outcomes, whereas these have been still unsatisfactory in metastatic tumors of OCS. We identified overexpression of lincRNA-ARF6 OCSs cell lines with high metastatic potentiality. The lincRNA-ARF6 regulated ARF6 expression, but not related with motility and invasion of these cell lines. Further studies will be needed for contribution of non-coding RNA in OCSs metastasis.

Research Products

• [Journal Article] Neural cell adhesion molecule (CD56)-positive B cell lymphoma of the urinary bladder (2016)
  • Author(s): Kawasaki T, Suzuki M, Sato A, Yashima-Abo A, Satoh T, Kato R, Kato Y, Obara W, Shimoyama T, Ishida Y, Sugai T
  • Journal Title: J Clin Pathol Volume: 69 Issue: 1 Pages: 89-92
  • DOI: 10.1136/jclinpath-2015-203250
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus (2015)
  • Author(s): Honma H, Takahashi Y, Matsui M, Satoh T, Fukuda I, Takahashi K, Takebe N, Nagasawa K, Ono M, Sasai T, Kajiwara T, Sugai T, Satoh J, Ishigaki Y.
  • Journal Title: Internal Medicine Volume: 54 Issue: 24 Pages: 3165-3169
  • DOI: 10.2169/internalmedicine.54.4945
  • NAID: 130005114256
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Classical Hodgkin lymphoma occurring in association with progressive transformation of germinal center. (2014)
  • Author(s): Yashima-Abo A, Satoh T, Shimosegawa K, Ishida Y, Masuda T.
  • Journal Title: J Clin Exp Hematop. Volume: 54 Pages: 205-209