| Project/Area Number |
26670180
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MORITA Shigeki 東京大学, 医学系研究科, 助教 (30707021)
ASO Tatsuya 帝京大学, 医学部, 助教 (30585401)
KUMAGAI Arisa 帝京大学, 医学部, 助教 (50596963)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 胃癌 / クロマチンリモデリング因子 / メチル化 / エピジェネティクス / 細胞培養 / 免疫組織化学的染色 / DNAメチル化 / 免疫組織化学 |
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| Outline of Final Research Achievements |
We studied the significance of chromatin remodeling factors in gastric cancer. We investigated 468 cases of gastric cancer and 47 cases of gastric adenoma with immunohistochemical staining. ARIDs were down-regulated in those gastric neoplasms and gradually decreased during gastric carcinogenesis. ARID1A is strongly related to clinicopathological factors among ARIDs. Decrease of ARID1A solely associated to poorer prognosis in advanced gastric cancer. Other chromatin remodeling factors, such as SMARCC1, PBRM1, and BRG1, showed similar decrease in gastric neoplasms. Further study using cell culture revealed that DNA methylation might cause ARIDs decrease.
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