Research Project
Grant-in-Aid for Challenging Exploratory Research
The aim of the study was to comprehensively reveal gene expression profile found in the “leading cells” that locate in the invasive forefront of cancer cell groups, based on the “monolayer culture model”, which we previously developed and “scratch assay” of cancer cells in culture. We identified several candidate genes that are specifically upregulated in the leading cells in culture. However, our immunohistochemistry on lung cancer tissues did not show specific expression of the products of those genes in the leading cells. We next identified a component of the intercellular adhesion as a candidate interacting protein for Girdin that is known as a critical regulator of collective migration of neuroblasts. The dynamics of cell-cell adhesion is an important property of cells that undergo collective migration. The identified protein complex, therefore, may have a role in the collective migration of cells.
All 2016 2015 2014
All Journal Article (5 results) (of which Peer Reviewed: 4 results, Open Access: 3 results, Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results, Invited: 1 results)
Sci Rep
Volume: 6 Issue: 1 Pages: 22288-22288
10.1038/srep22288
Pathol Int
Volume: 66 Issue: 4 Pages: 183-192
10.1111/pin.12391
120005893271
日本臨床
Volume: 74 Pages: 523-532
Cancer Science
Volume: 107 Issue: 2 Pages: 133-139
10.1111/cas.12848
EMBO Journal.
Volume: 33 Issue: 18 Pages: 2098-2112
10.15252/embj.201488289
