Identification of molecular mechanisms that regulate collective invasion of cancer cells
Project/Area Number |
26670188
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Nagoya University |
Principal Investigator |
Enomoto Atsushi 名古屋大学, 医学(系)研究科(研究院), 准教授 (20432255)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 集団移動 / 集団浸潤 / 癌 / Girdin / 集団的浸潤 / がん / 集団的移動 |
Outline of Final Research Achievements |
The aim of the study was to comprehensively reveal gene expression profile found in the “leading cells” that locate in the invasive forefront of cancer cell groups, based on the “monolayer culture model”, which we previously developed and “scratch assay” of cancer cells in culture. We identified several candidate genes that are specifically upregulated in the leading cells in culture. However, our immunohistochemistry on lung cancer tissues did not show specific expression of the products of those genes in the leading cells. We next identified a component of the intercellular adhesion as a candidate interacting protein for Girdin that is known as a critical regulator of collective migration of neuroblasts. The dynamics of cell-cell adhesion is an important property of cells that undergo collective migration. The identified protein complex, therefore, may have a role in the collective migration of cells.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells2016
Author(s)
Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 22288-22288
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.2014
Author(s)
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi and Masahide Takahashi.
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Journal Title
EMBO Journal.
Volume: 33
Issue: 18
Pages: 2098-2112
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin2015
Author(s)
Weng, L., Enomoto, A., Asai, N., Kato, T., Watanabe, T., Kaibuchi, K., Takahashi, M
Organizer
The 6th EMBO meeting
Place of Presentation
バーミンガム(英国)
Year and Date
2015-09-06
Related Report
Int'l Joint Research
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