Investigating the mechanisms of regulatory T cell expansion by aging

• Project/Area Number: 26670192
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Nagoya City University
• Principal Investigator: Yamazaki Sayuri 名古屋市立大学, 医学(系)研究科(研究院), 教授 (70567255)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 制御性T細胞 / 樹状細胞 / 加齢 / 免疫抑制 / 免疫寛容 / 老化

Outline of Final Research Achievements

Immune suppression in aging contributes to developing serious infection and cancer. To improve the immune suppression in aged population and contribute to expand healthy aged people, we invested the mechanisms how regulatory T cells are increased in aging using aged mice. We found that a special subset of regulatory T cells that increased in aged mice (Yamazaki et al, manuscript in preparation), and the research is ongoing currently.

Research Products

• [Int'l Joint Research] Rockefeller University(米国)
• [Int'l Joint Research] Nanyang Technological University(シンガポール)
• [Journal Article] 制御性T細胞の恒常性と皮膚 (2016)
  • Author(s): 山崎小百合、森田明理
  • Journal Title: 臨床皮膚科 Volume: 5
• [Journal Article] 加齢で増加する制御性T細胞と免疫抑制 (2016)
  • Author(s): 山崎小百合
  • Journal Title: 加齢皮膚医学セミナー Volume: 11
• [Journal Article] The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. (2015)
  • Author(s): Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, La Win MK, Yau YH, Guo T, See PC, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH.
  • Journal Title: Nat Immunol. Volume: May;16(5) Issue: 5 Pages: 505-516
  • DOI: 10.1038/ni.3125
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Histone methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of Talin (2015)
  • Author(s): Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, Win MK, Yau YH, Guo T, See PC, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH.
  • Journal Title: Nat Immunol Volume: 16 Pages: 505-516
  • Peer Reviewed
• [Journal Article] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin. (2014)
  • Author(s): S. Yamazaki, A. Nishioka, S. Kasuya, N. Ohkura, H. Hemmi, T. Kaisho, O. Taguchi, S. Sakaguchi, A. Morita
  • Journal Title: J Immunol Volume: 193(11) Issue: 11 Pages: 5488-97
  • DOI: 10.4049/jimmunol.1400985
  • Peer Reviewed
• [Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease. (2014)
  • Author(s): Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
  • Journal Title: Science Volume: 346 Issue: 6207 Pages: 363-8
  • DOI: 10.1126/science.1259077
  • Peer Reviewed
• [Journal Article] Antigen delivery to CD11c^+ CD8^- dendritic cells induces protective immune response against experimental melanoma in mice in vivo (2014)
  • Author(s): Neubert K, Lehmann C, Heger L, Baranska A, Staedtler A, Buchholz V, Yamazaki S, Heidkamp G, Eissing N, Zebroski H, Nussenzweig M, Nimmerjahn F, Dudziak D
  • Journal Title: J Immunol Volume: (in press) Issue: 12 Pages: 5830-5838
  • DOI: 10.4049/jimmunol.1300975
  • Peer Reviewed
• [Presentation] Ultraviolet B (UVB) Exposure Expands Thymus-derived Foxp3＋CD4＋Regulatory T Cells with Distinctive Phenotype in The Skin. (2015)
  • Author(s): ayuri Yamazaki , Mizuyu Odanaka, Akiko Nishioka , Saori Kasuya , Shoryu Takayama , Masaki Imai , Osamu Taguchi, Akimichi Morita
  • Organizer: 第40回研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2015-12-10
• [Presentation] 免疫の制御を利用した感染症や癌に対する新しい治療戦略 (2015)
  • Author(s): 山崎小百合
  • Organizer: 第28回日本外科感染症学会総会学術集会
  • Place of Presentation: 名古屋東急ホテル（名古屋市）
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] Foxp3+CD4+ Regulatory T Cells with Decreased Motility Accumulate in Aged Lymphoid Tissue. (2015)
  • Author(s): Sayuri Yamazaki, Masaki Imai, Akiko Nishioka, Saori Kasuya, Mizuyu Odanaka, Osamu Taguchi, Akimichi Morita
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(札幌市）
  • Year and Date: 2015-11-20
• [Presentation] Phenotype analysis of Foxp3+CD4+ regulatory T cells in the skin after Ultraviolet B exposure. (2015)
  • Author(s): Mizuyu ODANAKA, Sayuri YAMAZAKI , Akiko NISHIOKA , Saori KASUYA , Shoryu TAKAYAMA, Masaki IMAI, Osamu TAGUCHI, Akimichi MORITA
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(札幌市）
  • Year and Date: 2015-11-20
• [Presentation] Differential roles of complement anaphylatoxin C5a and C5adesArg. (2015)
  • Author(s): TAKAYAMA Shoryu, ODANAKA Mizuyu, Ohta Rieko, IMAI Masaki, YAMAZAKI Sayuri
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(札幌市）
  • Year and Date: 2015-11-18
• [Presentation] Ultraviolet B-expanded Thymus-derived Foxp3+ Regulatory T Cells Interact with Dendritic Cells in The Skin (2015)
  • Author(s): Sayuri Yamazaki1, Akiko Nishioka2, Saori Kasuya2, Naganari Ohkura3,4, Hiroaki Hemmi5,6, Tsuneyasu Kaisho5,6, Osamu Taguchi2, Shimon Sakaguchi3, Akimichi Morita2
  • Organizer: 14th International Workshop on Lngerhans Cells
  • Place of Presentation: Kyoto International Community House(Kyoto, JAPAN)
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Analysis of C5a receptor expression on the various subsets of dendritic cells (2015)
  • Author(s): Kohei Tsujimura, Rieko Ohta, Masaki Imai, Sayuri Yamazaki
  • Organizer: 14th International Workshop on Lngerhans Cells
  • Place of Presentation: Kyoto International Community House(Kyoto, JAPAN)
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Phenotype analysis of Foxp3＋CD4＋regulatory T cells and dendritic cells in the skin after Ultraviolet B exposure (2015)
  • Author(s): Mizuyu Odanaka, Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Syoryu Takayama,Masaki Imai, Akimichi Morita
  • Organizer: 14th International Workshop on Lngerhans Cells
  • Place of Presentation: Kyoto International Community House(Kyoto, JAPAN)
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] 加齢で増殖する制御性T細胞サブセットの解析 (2015)
  • Author(s): 山崎小百合
  • Organizer: 第１１回加齢皮膚医学研究会
  • Place of Presentation: ホテルサンルートプラザ名古屋（愛知県）
  • Year and Date: 2015-09-05 – 2015-09-06
  • Invited
• [Presentation] 皮膚の制御性T細胞 (2015)
  • Author(s): 山崎小百合
  • Organizer: 第３０回日本乾癬学会
  • Place of Presentation: ウエステインホテル名古屋（愛知県）
  • Year and Date: 2015-09-04 – 2015-09-05
  • Invited
• [Presentation] C5a第２レセプターC5L2の発現解析 (2015)
  • Author(s): 辻村幸平、太田里永子、今井優樹、山崎小百合
  • Organizer: 第52回補体シンポジウム
  • Place of Presentation: 名古屋大学医学部附属病院（名古屋市）
  • Year and Date: 2015-08-20
• [Presentation] 樹状細胞と制御性T細胞による免疫応答制御 (2015)
  • Author(s): 山崎小百合
  • Organizer: 第２回GSK免疫皮膚カンファレンス
  • Place of Presentation: 大津プリンスホテル（大津市）
  • Year and Date: 2015-07-25
  • Invited
• [Presentation] 制御性T細胞と樹状細胞による免疫制御 (2015)
  • Author(s): 山崎小百合
  • Organizer: 第５４回湯島皮膚科談話会
  • Place of Presentation: ステーションカンファランス万世橋（東京都、千代田区）
  • Year and Date: 2015-07-04
  • Invited
• [Presentation] 樹状細胞による制御性T細胞の制御 (2015)
  • Author(s): 山崎小百合
  • Organizer: 第25回免疫細胞療法研究会
  • Place of Presentation: 福島県立医科大学（福島市）
  • Year and Date: 2015-04-20
  • Invited
• [Presentation] Skin controls maintenance of thymus-derived Foxp3+ regulatory T cells in the periphery by ultraviolet B exposure. (2014)
  • Author(s): Yamazaki S
  • Organizer: The 39th Annual Meeting of Japanese Society for Investigative Dermatology
  • Place of Presentation: 大阪ホテル阪急エキスポパーク（大阪府）
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin. (2014)
  • Author(s): Yamazaki S
  • Organizer: The 43rd Annual Meeting of Japanese Immunological Society
  • Place of Presentation: 京都国際会議場（京都府）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] リンパ球の機能、特に制御性T細胞について (2014)
  • Author(s): 山崎小百合
  • Organizer: 第１１３回日本皮膚科学会
  • Place of Presentation: 京都国際会議場（京都府）
  • Year and Date: 2014-05-30 – 2014-06-01
  • Invited
• [Presentation] 皮膚における制御性T細胞のホメオスタシスの研究 (2014)
  • Author(s): 山崎小百合
  • Organizer: 第１１３回日本皮膚科学会
  • Place of Presentation: 京都国際会議場（京都府）
  • Year and Date: 2014-05-30 – 2014-06-01
  • Invited
• [Presentation] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin. (2014)
  • Author(s): Yamazaki S
  • Organizer: The Annual Meeting of Society for Investigative Dermatology 2014
  • Place of Presentation: Albuquerque（USA）
  • Year and Date: 2014-05-07 – 2014-05-10
• [Remarks] 名古屋市立大学大学院医学研究科免疫学
  • URL: http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html
• [Remarks] 名古屋市立大学大学院医学研究科
  • URL: http://www.med.nagoya-cu.ac.jp/w3med/labo/immune.dir/index.html
• [Remarks] 名古屋市立大学大学院医学研究科加齢環境皮膚科学
  • URL: http://www.med.nagoya-cu.ac.jp/derma.dir/index.htm