| Project/Area Number |
26670193
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUDO Yuka 東京理科大学, 薬学部, 助教 (70646695)
OKITA Naoyuki 公益財団法人佐々木研究所, 付属研究所, 研究員 (60453841)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | カロリー制限 / ミトコンドリア / 品質管理 / シグナルペプチダーゼ / Sirt3 / Mipep / ノックアウトマウス / カロリーの制限（CR） / 白色脂肪組織（WAT） / Srebp-1c / ミトコンドリアの品質管理 / ミトコンドリアシグナルペプチターゼ / ミトコンドリア病 / ミトコンドリア品質管理 / ミトコンドリアシグナルペプチダーゼ / SIRT3 / ミトファジー / PINK1/PARKIN |
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| Outline of Final Research Achievements |
We discovered that the activation of Sirt3 processing plays an important role of the improvement of mitochondrial (MT) quality control by anti-aging and prolongevity actions of calorie restriction. In the processing of the MT protein, MT signal peptidases are involved. We found that two signal peptidases, MPP and Mipep, were involved in the processing of Sirt3 protein. In addition, CR upregulated the expression of Mipep but not MPP. Therefore, we considered Mipep is important to the improvement of CR-associated MT quality control. In order to prove in vivo, the organ-specific Mipep-deficient mice were created. In the future, we are going to analyze these mice.
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