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A novel trial approach for gene-manipulation of tsetse fly

Research Project

Project/Area Number 26670197
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Parasitology (including sanitary zoology)
Research InstitutionKobe Tokiwa University (2015-2017)
Tokyo Medical and Dental University (2014)

Principal Investigator

Suzuki Takashi  神戸常盤大学, 保健科学部, 教授 (70305530)

Research Collaborator Alexander Egyir-Yawson  Ghana Atomic Energy Commission
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsツェツェバエ / ディフェンシン / アフリカトリパノソーマ原虫 / アフリカトリパノソーマ / 遺伝子組換え / 胎生昆虫
Outline of Final Research Achievements

Tsetse flies (Glossina spp.) transmit African trypanosomiasis. In order to effectively control the disease, development of a novel gene manipulating method is expected, which generates the tsetse fly refractory to African trypanosomes. For that purpose, Glossina insectary was firstly set up and preliminary anesthetic system of Glossina was established. Then, anti-microorganism activity of Glossina palpalis defensin(GpDef)was analyzed. The results showed that the molecule possessed a specific anti-trypnosomal activity.
Initial idea of injecting DNA molecules into G. palpalis spermatheca was not successful. Thus in order to see the feasibility of establishing future gene modification system, the following analyses were carried out: a motility and exosome-related molecule of African trypanosome was analyzed and Glossina genome was surveyed in detail for polydnavirus.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (2 results) (of which Invited: 1 results)

  • [Int'l Joint Research] University of Ghana(Ghana)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Ghana Atomic Energy Commission/NMIMR(ガーナ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] The Role of Detoxification Enzymes in the Adaptation of the Major Malaria Vector Anopheles gambiae (Giles; Diptera: Culicidae) to Polluted Water.2017

    • Author(s)
      King SA, Onayifeke B, Akorli J, Sibomana I, Chabi J, Manful-Gwira T, Dadzie S, Suzuki T, Wilson MD, Boakye DA, de Souza DK
    • Journal Title

      Journal of medical entomology

      Volume: 54(6) Issue: 6 Pages: 1674-1683

    • DOI

      10.1093/jme/tjx164

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Toxoplasma gondii infections among pregnant women, children and HIV-seropositive persons in Accra, Ghana2016

    • Author(s)
      Ayi I, Sowah OK A, Blay EA, Suzuki T, Ohta N, Ayeh-Kumi FP
    • Journal Title

      Tropical Medicine and Health

      Volume: 44 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s41182-016-0018-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk of transmission of viral haemorrhagic fevers and the insecticide susceptibilitystatus of aedes aegypti (linnaeus) in some sites in Accra, Ghana2016

    • Author(s)
      Suzuki T,Osei HN J, Sasaki A, Adimazoya M, Appawu M, Boakye D, Ohta N, Dadzie S
    • Journal Title

      Ghana Medical Journal

      Volume: 5 Pages: 136-141

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluating triethylamine in the anaesthesia of Anopheles gambiae mosquitoes.2016

    • Author(s)
      De Souza KD, Osei-Poku J, Suzuki T
    • Journal Title

      African Entomology

      Volume: 24 Issue: 1 Pages: 236-240

    • DOI

      10.4001/003.024.0236

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Congenital toxoplasmosis and pregnancy malaria detection post-partum: Effective diagnosis and its implication for efficient management of congenital infection.2015

    • Author(s)
      Blay EA, Ghansah A, Otchere J, Koku R, Kwofie KD, Bimi L, Suzuki T, Ohta N, Ayi I.
    • Journal Title

      Parasitology International

      Volume: 64 Issue: 6 Pages: 603-608

    • DOI

      10.1016/j.parint.2015.08.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 熱帯疾患コントロールへのアプローチ2016

    • Author(s)
      鈴木高史
    • Organizer
      バイオナノシステムズ研究会
    • Place of Presentation
      九州大学大学院総合理工学府
    • Year and Date
      2016-01-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 本学(神戸常盤大学)におけるグローバル教育の現況2016

    • Author(s)
      鈴木高史、柳田潤一郎、野村秀明、坂本秀生
    • Organizer
      第11回日本臨床検査学教育学会
    • Place of Presentation
      神戸常盤大学
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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