| Project/Area Number |
26670206
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Junji 北海道大学, 大学院保健科学研究院, 講師 (50359486)
NAKAMURA Shinji 順天堂大学, 医学研究科, 助教 (40207882)
HAGA Sanae 北海道大学, 大学院保健科学研究院, 博士研究員 (60706505)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 共生 / 原始的なクラミジア / アメーバ / アカントアメーバ / 感染制御 |
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| Outline of Final Research Achievements |
Previous our work has shown that obligate intracellular amoebal endosymbiont Neochlamydia has a critical role into host amoebal defense against harmful Legionella infection, causing amoebal killing. Here, to clarify the defense mechanism, we found a crucial piece that amoebal endosymbiotic Neochlamydia specifically could sense Legionella T4ASS (Lvh), but not T4BSS (Dot/Icm), presumably connecting to the host defense against harmful Legionella infection.
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