| Project/Area Number |
26670208
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
Shimizu Takeshi 千葉大学, 大学院医学研究院, 准教授 (70312840)
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| Co-Investigator(Kenkyū-buntansha) |
濱端 崇 国立研究開発法人国立国際医療研究センター, 感染症制御研究部, 細菌感染研究室長 (40311427)
野田 公俊 千葉大学, 大学院医学研究院, 教授 (60164703)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腸管出血性大腸菌 / 志賀毒素 / 嫌気状態 / 活性酸素種 / 増殖性 / 病原性 / 抗菌薬 / 嫌気条件 / 宿主防御機構 / 動物実験 / 嫌気性 / 薬剤耐性 |
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| Outline of Final Research Achievements |
Following the ingestion of contaminated food or water, enterohemorrahgic Escherichia coli (EHEC) enters the gastrointestinal tract and is released into the intestine. It is important for estimation of pathogenicity and host immuno resistance of EHEC under absolute anaerobic conditions. Thus, we determined growth rate, production of Shiga toxins, resistance against reactive oxygen species, expression of virulence factors and drug resistance in EHEC under absolute anaerobic conditions using anaerobic chamber.
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