Genetic analysis in patients infected with H5N1 avian influenza virus
| Project/Area Number |
26670226
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
Nakayama Emi 大阪大学, 微生物病研究所, 准教授 (70324845)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | H5N1 / 感受性 / シアル酸転移酵素 / SNP / ウイルス / インフルエンザ |
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| Outline of Final Research Achievements |
Despite its high pathogenicity in infected human cases, the numbers of patients infected with H5N1 were still small. Most of H5N1 viruses isolated from infected patients display the same binding affinity to avian-type receptors as avian H5N1. These facts prompted us to raise one hypothesis that patients infected with H5N1 virus had elevated susceptibility to H5N1 compared with other individuals. The genomic DNA was extracted from 4 H5N1-infected but recovered patients and from 10 donors and the genetic analysis was performed at 6 genes of ST3GAL and 2 genes of ST6GAL by next generation sequencer. There are 32 SNPs over-represented in infected cases in ST3GAL1, 3, 6 and ST6GAL1 genes. If we hypothesize that the individuals with rare SNPs bear susceptibility to H5N1, SNPs in ST6GAL1, 3 and 6 genes were supposed to be candidate SNPs.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Fibrocytes differ from macrophages but can be infected with HIV-1.2015
Author(s)
M. Hashimoto, H. Nasser, F. Bhuyan, N. Kuse, Y. Satou, S. Harada, K. Yoshimura, J. Sakuragi, K. Monde, Y. Maeda, S. Welbourn, K. Strebel, E.W.A. El-Wahab, M. Miyazaki , S. Hattori, N. Chutiwitoonchai, M. Hiyoshi, S. Oka, M. Takiguchi, S. Suzu.
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Journal Title
The Journal of Immunology
Volume: 195
Issue: 9
Pages: 4341-4350
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis.2016
Author(s)
Sultana T, Nakayama EE, Tobita S, Yokoyama M, Seki Y, Saito A, Nomaguchi M, Adachi A, Akari H, Sato H, Shioda T.
Organizer
CROI 2016
Place of Presentation
ボストン
Year and Date
2016-02-22
Related Report
Int'l Joint Research
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[Presentation] テノフォビア服用による尿中ベータグロブリンの高値はABCC4遺伝子の一塩基多型と相関する2015
Author(s)
中山 英美, Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Pimrapat Tengtrakulcharoen, Wisit Prasithsirikul, Chariya Sangsajja, 塩田 達雄
Organizer
第29回日本エイズ学会学術集会・総会
Place of Presentation
東京
Year and Date
2015-11-30
Related Report
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[Presentation] Genome-wide association study of HIV-related lipoatrophy in Thai patients: Association of a DLGAP1 polymorphism with fat loss.2014
Author(s)
中山英美, Uttayamakul Sumonmal, Tiphaine Oudot-Mellakh, Pimrapat Tengtrakulcharoen, Julien Guergnon, Jean-Francois Delfraissy, Srisin Khusmith,Chariya Sangsajja, Sirirat Likanonsakul, Ioannis Theodorou,塩田達雄
Organizer
第28回日本エイズ学会学術集会・総会
Place of Presentation
大阪
Year and Date
2014-12-03 – 2014-12-05
Related Report
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