Elucidation of the mechanisms of TRAs expression independently of Aire
| Project/Area Number |
26670231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Takaba Hiroyuki 東京大学, 大学院医学系研究科(医学部), 特任助教 (50637444)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAYANAGI Hiroshi 東京大学, 大学院医学系研究科, 教授 (20334229)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | T細胞 / 免疫寛容 / Self tolerance / 獲得免疫 / 自己寛容 |
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| Outline of Final Research Achievements |
T cell repertoire selection in the thymus comprises the positive and negative selection in the cortex and medulla, respectively. A promiscuous expression of a wide array of self-antigens in the thymus is essential for the negative selection of self-reactive T cells and the regulatory T cell development, which are crucial for the establishment of central tolerance. Aire was thought to be the exclusive factor regulating the expression of tissue-restricted antigens, but Fezf2 emerged as a transcription factor playing a key role in this regulation. Fezf2 is selectively expressed in thymic medullary epithelial cells and suppresses the onset of autoimmune reactions.
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Report
(4 results)
Research Products
(7 results)
