| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
T cell repertoire selection in the thymus comprises the positive and negative selection in the cortex and medulla, respectively. A promiscuous expression of a wide array of self-antigens in the thymus is essential for the negative selection of self-reactive T cells and the regulatory T cell development, which are crucial for the establishment of central tolerance. Aire was thought to be the exclusive factor regulating the expression of tissue-restricted antigens, but Fezf2 emerged as a transcription factor playing a key role in this regulation. Fezf2 is selectively expressed in thymic medullary epithelial cells and suppresses the onset of autoimmune reactions.
|
