• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of murine model of autoimmune diseases

Research Project

Project/Area Number 26670232
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

Miyadera Hiroko  国立研究開発法人国立国際医療研究センター, その他部局等, その他 (40361464)

Research Collaborator Okamura Tadashi  国立研究開発法人国立国際医療研究センター, 研究所, 室長 (00333790)
Nakano Kenta  国立研究開発法人国立国際医療研究センター, 研究所, 技術職員
Takanashi Rieko  国立研究開発法人国立国際医療研究センター, 研究所, 技術職員
Okabe Yuki  国立研究開発法人国立国際医療研究センター, その他部局等, 技術補佐員
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords主要組織適合性抗原 / 自己免疫疾患 / ヒト白血球抗原 / ヒト白血球抗原(HLA)
Outline of Final Research Achievements

Susceptibility to autoimmune diseases varies greatly among individuals. It has been known that various environmental and genetic factors contribute to susceptibility to autoimmune diseases. For certain autoimmune diseases, genes that encode human leukocyte antigens (HLA) is the strongest susceptibility loci, however, underlying mechanisms remain elusive. In this study, we have studied mechanism of autoimmune diseases by modifying the genes that encode major histocompatibility complex (MHC) of mouse, which is analogous to human HLA, to understand potential roles of HLA/MHC class II in the development of autoimmunity.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Autoimmune susceptible HLA alleles encode unstable proteins.2015

    • Author(s)
      Miyadera, H., Ohashi, J., Lernmark, A., Kitamura, T., and Tokunaga, K.
    • Journal Title

      J. Clin. Invest.

      Volume: 125 Issue: 1 Pages: 275-291

    • DOI

      10.1172/jci74961

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of human leukocyte antigens (HLA) with autoimmune diseases: Challenges in identifying the mechanism.2015

    • Author(s)
      Miyadera H*, Tokunaga K.
    • Journal Title

      J Hum Genet

      Volume: 60 Issue: 11 Pages: 697-702

    • DOI

      10.1038/jhg.2015.100

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement2014

    • Author(s)
      Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, Miyadera H, Sugiyama E, Maekawa K, Nakamura R, Nagato M, Aihara M, Matsunaga K, Takahashi Y, Furuya H, Muramatsu M, Ikezawa Z, Kinoshita S.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 4862-4862

    • DOI

      10.1038/srep04862

    • URL

      https://pure.teikyo.jp/en/publications/6f008634-2fec-4098-9778-3bf0f47687a5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] HLAと自己免疫疾患の関連のメカニズム2015

    • Author(s)
      宮寺 浩子
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2018-09-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi