Analysis of EAE insensitive autoimmune prone mice
Project/Area Number |
26670240
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Toho University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KUWABARA Taku 東邦大学, 医学部, 講師 (40385563)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | T細胞 / SATB1 / 自己免疫疾患 / SATB1 / 免疫寛容 / 自己免疫 |
Outline of Final Research Achievements |
Special AT-rich binding protein-1 (SATB1) is a chromosome organizer. Hematopoietic cell specific deletion of SATB1 in mice (SATB1cKO) leads to autoimmune manifestation; however, SATB1cKO mice were resistant against EAE. Spontaneous EAE with 2D2 transgenic TCR was not observed in SATB1cKO mice. Since TCR signal strength was weak in T cells from SATB1cKO mice, these results imply that T cells in SATB1cKO mice at childhood might play a role in pathogenesis of autoimmune diseases.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development2015
Author(s)
Bingtao Hao, Abani Kanta Naik , Akiko Watanabe , Hirokazu Tanaka , Liang Chen , Hunter W Richards, Motonari Kondo, Ichiro Taniuchi, Yoshinori Kohwi, Terumi Kohwi-Shigematsu, Michael S Krangel
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Journal Title
Journal of experimental medicine
Volume: 212
Issue: 5
Pages: 809-824
DOI
Related Report
Peer Reviewed
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[Presentation] 免疫寛容における分子制御機構の解析2014
Author(s)
田中ゆり子, グオシャンファ, 向津隆規, 早乙女壮彦, 桑原卓, 近藤元就
Organizer
Kyoto T cell Conference 第24回学術集会
Place of Presentation
京都平安ホテル 京都府 京都市
Year and Date
2014-05-16 – 2014-05-17
Related Report
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