B cell memory machinery in the intestinal IgA responses
| Project/Area Number |
26670241
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
KUNISAWA Jun 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチンマテリアルプロジェクト, プロジェクトリーダー (80376615)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 免疫学 / 発生・分化 / メタボリズム / ビタミン |
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| Outline of Final Research Achievements |
It was demonstrated that in the intestinal IgA exhibits memory responses, but underlying mechanisms remain unclear. In this study, we performed metabolic analysis for energy metabolism that seems to be involved in the induction and maintenance of intestinal IgA responses. Naive B cells from the Peyer’s patches predominantly use TCA cycle, whereas IgA producing cells in the intestinal lamina propria shift their energy metabolism to glycolysis-initiated one. In agreement with these metabolic changes, naive B cells were dramatically reduced in mice lacking vitamin B1, an essential co-factor for the TCA cycle and intestinal IgA responses against oral vaccine were consequently impaired. These findings suggest that energy metabolism during B cell differentiation for intestinal IgA responses was changed, which is possibly associated with the induction and maintenance of intestinal IgA memory responses.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Mode of bioenergetic metabolism during B cell differentiation in the intestine determines the distinct requirement for vitamin B12015
Author(s)
J. Kunisawa, Y. Sugiura, T. Wake, T. Nagatake, H. Suzuki, R. Nagasawa, S. Shikata, K. Honda, E. Hashimoto, Y. Suzuki, M. Setou, M. Suematsu, H. Kiyono
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Journal Title
Cell Rep
Volume: 13
Issue: 1
Pages: 122-131
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The enzyme cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.2014
Author(s)
Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
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Journal Title
Immunity
Volume: 40
Issue: 4
Pages: 530-541
DOI
Related Report
Peer Reviewed / Open Access
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