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Central neuronal circuit underlying odor-induced analgesia

Research Project

Project/Area Number 26670290
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionKagoshima University

Principal Investigator

Kashiwadani Hideki  鹿児島大学, 医歯学域医学系, 講師 (70328376)

Co-Investigator(Renkei-kenkyūsha) KUWAKI TOMOYUKI  鹿児島大学, 医歯学域医学系, 教授 (80205260)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords鎮痛 / 匂い / 香気誘発性鎮痛 / 下行性抑制系 / odor / analgesia / orexin
Outline of Final Research Achievements

To assess whether the olfactory input mediates odorant-X-induced analgesia, we examine the analgesia in olfactory deprived mouse. The formalin test and the hot plate test revealed that the analgesic effects were not observed in olfactory deprived mouse, indicating that the olfactory input evoked by the odorant-X is necessary for the analgesia. Next, we examine the duration of the analgesic effects. The results indicated that the analgesic effects lasted at least 5 minutes after the odorant-X exposure. Furthermore, we examined the contribution of intrinsic opioid system to the analgesic effects, and found that the intrinsic analgesic system including mu-opioid receptors mediates the odorant X-induced analgesia in mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] The endogenous opioid system mediates Odorant-X-induced analgesia in mice2016

    • Author(s)
      Eri Inoue, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Central neuronal circuit underlying odor-induced analgesia estimated by c-fos expression in mice2015

    • Author(s)
      Sodemi Ishikawa, Shogo Tashiro, Ran Yamaguchi, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
    • Organizer
      The 45th Annual meeting of Society for Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Odorant X 誘発性鎮痛はストレス誘発性鎮痛とは異なる2015

    • Author(s)
      山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸(神戸国際会議場)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 芋焼酎含有香気Odorant X 誘発性鎮痛2015

    • Author(s)
      永田敬一郎、山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸(神戸国際会議場)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 視床下部オレキシンニューロンを介した匂い誘発性鎮痛の発現2014

    • Author(s)
      山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Odor-induced analgesic effect in mice2014

    • Author(s)
      Hideki Kashiwadani, Shogo Tashiro, Ran Yamaguchi, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki
    • Organizer
      9th FENS forum of neuroscience
    • Place of Presentation
      Milan(イタリア)
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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