| Project/Area Number |
26670290
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWAKI TOMOYUKI 鹿児島大学, 医歯学域医学系, 教授 (80205260)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 鎮痛 / 匂い / 香気誘発性鎮痛 / 下行性抑制系 / odor / analgesia / orexin |
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| Outline of Final Research Achievements |
To assess whether the olfactory input mediates odorant-X-induced analgesia, we examine the analgesia in olfactory deprived mouse. The formalin test and the hot plate test revealed that the analgesic effects were not observed in olfactory deprived mouse, indicating that the olfactory input evoked by the odorant-X is necessary for the analgesia. Next, we examine the duration of the analgesic effects. The results indicated that the analgesic effects lasted at least 5 minutes after the odorant-X exposure. Furthermore, we examined the contribution of intrinsic opioid system to the analgesic effects, and found that the intrinsic analgesic system including mu-opioid receptors mediates the odorant X-induced analgesia in mice.
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