Central neuronal circuit underlying odor-induced analgesia

• Project/Area Number: 26670290
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Kagoshima University
• Principal Investigator: Kashiwadani Hideki 鹿児島大学, 医歯学域医学系, 講師 (70328376)
• Co-Investigator(Renkei-kenkyūsha): KUWAKI TOMOYUKI 鹿児島大学, 医歯学域医学系, 教授 (80205260)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 鎮痛 / 匂い / 香気誘発性鎮痛 / 下行性抑制系 / odor / analgesia / orexin

Outline of Final Research Achievements

To assess whether the olfactory input mediates odorant-X-induced analgesia, we　examine the analgesia in olfactory deprived mouse. The formalin test and the　hot plate test revealed that the analgesic effects were not observed in olfactory deprived mouse, indicating that the olfactory input evoked by the odorant-X is necessary for the analgesia. Next, we examine the duration of the analgesic effects. The results indicated that the analgesic effects lasted at least 5 minutes after the odorant-X exposure. Furthermore, we examined the contribution of intrinsic opioid system to the analgesic effects, and found that the intrinsic analgesic system including mu-opioid receptors mediates the odorant X-induced analgesia in mice.

Research Products

• [Presentation] The endogenous opioid system mediates Odorant-X-induced analgesia in mice (2016)
  • Author(s): Eri Inoue, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] Central neuronal circuit underlying odor-induced analgesia estimated by c-fos expression in mice (2015)
  • Author(s): Sodemi Ishikawa, Shogo Tashiro, Ran Yamaguchi, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
  • Organizer: The 45th Annual meeting of Society for Neuroscience
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Odorant X 誘発性鎮痛はストレス誘発性鎮痛とは異なる (2015)
  • Author(s): 山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹
  • Organizer: 第92回日本生理学会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 芋焼酎含有香気Odorant X 誘発性鎮痛 (2015)
  • Author(s): 永田敬一郎、山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹
  • Organizer: 第92回日本生理学会
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 視床下部オレキシンニューロンを介した匂い誘発性鎮痛の発現 (2014)
  • Author(s): 山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹
  • Organizer: 第37回日本神経科学学会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Odor-induced analgesic effect in mice (2014)
  • Author(s): Hideki Kashiwadani, Shogo Tashiro, Ran Yamaguchi, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki
  • Organizer: 9th FENS forum of neuroscience
  • Place of Presentation: Milan（イタリア）
  • Year and Date: 2014-07-05 – 2014-07-09