| Project/Area Number |
26670291
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ITO SEIJI 関西医科大学, 医学部, 教授 (80201325)
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| Co-Investigator(Kenkyū-buntansha) |
松村 伸治 関西医科大学, 医学部, 講師 (70276393)
西田 和彦 関西医科大学, 医学部, 助教 (80448026)
井上 明俊 関西医科大学, 医学部, 助教 (50709152)
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| Research Collaborator |
NGUYEN Huu Tu
PHAM Minh Vuong
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 動物モデル / 掻痒 / 痛覚 / グルタミン酸受容体 / ガストリン遊離ペプチド / c-fos / 急性掻痒動物モデル / 慢性掻痒動物モデル / 三叉神経節 / クロロキン / arc / セロトニン / 一次求心性線維 / 大槽内投与 |
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| Outline of Final Research Achievements |
Itch or pruritus has been identified as an unpleasant cutaneous sensation that provokes the desire to scratch and is a tormenting symptom in patients with atopic dermatitis and hemodialysis. Itch disappears by scratching the skin and strong scratching provokes pain. Thus, itch and pain are intimately related and may share similar pathways, but their mechanism remains largely unknown.
In the present study, we applied pruritic agents to the cheek of mice and provoked scratching behaviors. The present study demonstrates that itch transmission pathway considerably shares pain transmission pathway but that agents that induce pain and itch are different.
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