A study of new cancer treatment method by neuromodulation

• Project/Area Number: 26670294
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Tohoku University
• Principal Investigator: OGURA Takahide 東北大学, 医学系研究科, 助教 (10312688)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 電気刺激 / ニューロモジュレーション / がん / 放射線照射 / 腫瘍血流 / 血流増加 / 血流減少 / 放射線治療 / 腫瘍 / 血流 / 酸素分圧

Outline of Final Research Achievements

I used electrical stimulation to control tumor blood flow and investigated whether the effect of radiation treatment on cancer therapy changes.
Tumor blood flow was increased for about 20% by electrical stimulation. And I also succeeded to decrease tumor blood flow for about 20% by changing stimulation conditions. Furthermore, combination of increase and decrease of blood flow with electrical stimulation combined with irradiation succeeded in delay of tumor growth about by 2 times. I clarified that increase and decrease of blood flow caused by electric stimulation improves treatment outcome of irradiation.

Research Products

• [Presentation] 電気刺激による血流制御を用いた放射線治療法 (2018)
  • Author(s): 小倉隆英
  • Organizer: 日本ニューロモジュレーション学会
  • Place of Presentation: 都市センターホテル（東京都・千代田区）
• [Presentation] ニューロモジュレーションによる腫瘍血流の減少 (2016)
  • Author(s): 小倉隆英
  • Organizer: 日本ニューロモジュレーション学会
  • Place of Presentation: 東京・都市センターホテル
  • Year and Date: 2016-05-07
• [Presentation] ニューロモジュレーションによる腫瘍内酸素分圧の制御 (2015)
  • Author(s): 小倉隆英
  • Organizer: 日本ニューロモジュレーション学会
  • Place of Presentation: 東京・都市センターホテル
  • Year and Date: 2015-04-25