Dermatitis caused by Fas/FasL and irradiation or cytotoxicity by GVH
| Project/Area Number |
26670300
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Nagoya University |
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Principal Investigator |
SUZUKI Haruhiko 名古屋大学, 医学(系)研究科(研究院), 准教授 (90283431)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | regulatory T cells / CD8+ cells / Fas/FasL / CD8+ |
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| Outline of Final Research Achievements |
We confirmed that the dermatitis model induced by irradiation and Bone Marrow transplantation (BMT) to Fas- or FasL-deficient mice as I proposed is caused by graft versus host reaction (GVH).
BMT was performed between any possible combinations of lpr, gld, and wild type (WT) （lpr＞lpr, WT>lpr, lpr>WT, gld>gld, WT>gld, gld>WT）and we discussed about immune disorders including dermatitis observed in the cases of either only host or only graft has mutation in Fas/FasL.
When the host mice were RAG-2KO, the bone marrow was reconstituted with the mixture of that of gld mice and WT (5.1) mice and their condition was followed up.
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Report
(2 results)
Research Products
(1 results)
