Supersaturated water as a novel ultrasound contrast agent
| Project/Area Number |
26670303
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バブル / 超音波 / 造影剤 / 飽和溶液 / マイクロバブル |
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| Outline of Final Research Achievements |
High pressure supersaturated water was produced and ultrasound was irradiated. As a result, very small microsized bubble formed within the liquid. Water pressurized to 0.5MPa in combination with air was made to a supersaturated water condition. The water was added to HL-60 leukemia cell in combination with PI staining agent and trypan blue stain. After ultrasound exposure, the cell showed uptake of the two stain which suggests that the microsized bubble contributed to this phenomenon. It was suggested that ultrasound delivered drugs within the cell without cell killing. The microbubbles also showed high acoustic signals using conventional ultrasound diagnostic device. Supersaturated water might be useful as a ultrasound contrast agent as well as drug delivery agent.
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Report
(3 results)
Research Products
(9 results)
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[Presentation] そこまできた超音波治療2015
Author(s)
立花 克郎
Organizer
第26回日本心エコー図学会学術集会
Place of Presentation
北九州国際会議場
Year and Date
2015-03-26 – 2015-03-28
Related Report
Invited
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[Presentation] 分子診断治療の今後の展望2014
Author(s)
立花 克郎
Organizer
第17日本栓子検出と治療学会
Place of Presentation
福岡市
Year and Date
2014-10-04 – 2014-10-05
Related Report
Invited
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