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Cryo-immunology; booster effects of cryotherapy on the anti-tumor immune response

Research Project

Project/Area Number 26670305
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionCenter for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital

Principal Investigator

Saito Hiroya  医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, がん研究部, 副部門長 (80524769)

Co-Investigator(Kenkyū-buntansha) 水上 裕輔  医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, がん研究部, 部門長 (30400089)
田村 保明  北海道大学, 産学・地域協働推進機構, 特任教授 (80322329)
Research Collaborator Nabeel Bardeesy  Massachusetts General Hospital Cancer Center, Associate Professor
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsCryotherapy / IVR / がん / 凍結治療 / Cryo-immunology / 悪性腫瘍 / 凍結療法 / がん凍結治療
Outline of Final Research Achievements

Cryotherapy (also called cryosurgery) is a treatment that uses extremely cold temperature to freeze and destroy cancer tissue. Although mainly employed in cases of prostate cancer, the therapeutic option can be used to treat a number of different types of cancer. Curiously, distant and untreated sites of disease can also be regressed after freezing a primary lesion, suggesting cryotherapy may stimulate an anti-tumor immune response. Given the tremendous potential of the local therapy that could also have systemic benefits, we sought to validate the ability of cryotherapy to stimulate a tumor recognition using allograft mouse pancreatic cancer system as a pre-clinical model. The tumor bearing animals treated by cryotherapy decreased growth of either primary or secondary tumor (an imaginary metastasis) relative to the controls. Cryotherapy offers an option for treating cancers that do not respond to standard treatments, and more studies are needed to determine the long-term effects.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 Other

All Journal Article (14 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (11 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Diversity of precursor lesions for pancreatic cancer: The genetics and biology of intraductal papillary mucinous neoplasm.2017

    • Author(s)
      Patra KC, Bardeesy N, Mizukami Y
    • Journal Title

      Clin Transl Gastroenterol

      Volume: 8 Issue: 4 Pages: e86-e86

    • DOI

      10.1038/ctg.2017.3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.2016

    • Author(s)
      Sugiyama Y, Sasajima J, Mizukami Y, et al.
    • Journal Title

      Pol J Pathol

      Volume: 67 Pages: 136-44

    • DOI

      10.5114/pjp.2016.61449

    • NAID

      120006658792

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pancreatic metastasis of angiosarcoma (Stewart-Treves syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.2016

    • Author(s)
      Sasajima J, Uehara J, Goto T, et al.
    • Journal Title

      Medicine

      Volume: 95 Issue: 33 Pages: e4316-e4316

    • DOI

      10.1097/md.0000000000004316

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.2016

    • Author(s)
      Saha SK, Gordan JD, Kleinstiver BP, et al.
    • Journal Title

      Cancer Discov

      Volume: 6 Issue: 7 Pages: 727-39

    • DOI

      10.1158/2159-8290.cd-15-1442

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tracking the Clonal Evolution of Adenosquamous Carcinoma, a Rare Variant of Intraductal Papillary Mucinous Neoplasm of the Pancreas.2016

    • Author(s)
      Matsuzaka S, Karasaki H, Ono Y, et al.
    • Journal Title

      Pancreas

      Volume: 45 Issue: 6 Pages: 915-8

    • DOI

      10.1097/mpa.0000000000000556

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.2016

    • Author(s)
      Driscoll DR, Karim SA, Sano M, et al.
    • Journal Title

      Cancer Res

      Volume: 76 Issue: 23 Pages: 6911-6923

    • DOI

      10.1158/0008-5472.can-16-0810

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tracking the clonal evolution of adenosquamous carcinoma, a rare variant of intraductal papillary mucinous neoplasm of the pancreas2016

    • Author(s)
      Matsuzaka S, Karasaki H, Ono Y, Ogata M, Oikawa K, Tamakawa S, Chiba S, Muraki M, Yokochi T, Funakoshi H, Kono T, Nagashima K, Mizukami Y.
    • Journal Title

      Pancreas

      Volume: xx

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The protein expression level of Gli2 is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.2016

    • Author(s)
      Sugiyama Y, Sasajima J, Mizukami Y, Koizumi K, Kawamoto T, Karasaki H, Yusuke Ono, Tanabe H, Fujiya M, Kohgo Y.
    • Journal Title

      Pol J Pathol

      Volume: xx

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Rare Case of Epidermoid Cyst in the Pancreatic Tail Invaginated from the Splenic Hilum: Long-term Alteration in Imaging Findings.2016

    • Author(s)
      Sugiyama Y, Kawamoto T, Sasajima J, Koizumi K, Karasaki H, Mizukami Y.
    • Journal Title

      Internal Medicine

      Volume: xx

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation.2015

    • Author(s)
      Tanaka T, Kajiwara T, Kutomi G, Kutomi G, Kurotaki T, Saito K, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y.
    • Journal Title

      Immunol Lett

      Volume: 167 Issue: 1 Pages: 34-40

    • DOI

      10.1016/j.imlet.2015.06.014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.2015

    • Author(s)
      Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y.
    • Journal Title

      Eur. J Immunology

      Volume: 0 Issue: 7 Pages: 0-0

    • DOI

      10.1002/eji.201445293

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cancer-associated oxidase ERO1-α regulates the expression of MHC class I molecule via oxidative folding.2015

    • Author(s)
      Kazuharu Kukita, Yasuaki Tamura, Tsutomu Tanaka, Toshimitsu Kajiwara, Goro Kutomi, Keita Saito, Koichi Okuya, Akari Takaya, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Tomohisa Furuhata, Koichi Hirata, Noriyuki Sato
    • Journal Title

      J Immunology

      Volume: 197 Issue: 10 Pages: 0-0

    • DOI

      10.4049/jimmunol.1303228

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.2015

    • Author(s)
      Tsutomu Tanaka, Toshimitsu Kajiwara, Toshihiko Torigoe, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
    • Journal Title

      J Immunology

      Volume: 194 Issue: 4 Pages: 2004-2010

    • DOI

      10.4049/jimmunol.1402538

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells2015

    • Author(s)
      Tsutomu Tanaka, Koichi Okuya, Goro Kutomi, Akari Takaya, Toshimitsu Kajiwara, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 1 Pages: 18-24

    • DOI

      10.1111/cas.12570

    • NAID

      120005593448

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] MOLECULAR TRACING OF INVASIVE IPMN LESIONS AND RELATED ADENOCARCINOMA TO DEFINE DISTINCT ROUTES TO INVASIVE CARCINOMAS OF THE PANCREAS.2016

    • Author(s)
      no Y, Omori Y, Takahashi K, Ambo Y, Shinohara T, Nishihara H, Tanaka S, Maguchi H, Karasaki H, Mizukami Y.
    • Organizer
      2016 Annual Meeting - American Pancreatic Association.
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] LIQUID BIOPSY FOR EARLY DETECTION OF PANCREATIC CANCER.2016

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Ogata M, Sugitani A, Koizumi K, Asahara S, Kawakubo K, Takahashi K, Maguchi H, Nagashima K.
    • Organizer
      2016 Annual Meeting - American Pancreatic Association.
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] A CASE PRESENTATION OF DISTAL BILE DUCT ADENOCARCINOMA; DISTINGUISHING BETWEEN CHOLANGIOCARCINOMA AND PANCREATIC DUCTAL ADENOCARCINOMA.2016

    • Author(s)
      Karasaki H, Mizukami Y, Ono Y, Ogata M, Yoshikawa D, Maejima T, Nagashima K, Toru K.
    • Organizer
      2016 Annual Meeting - American Pancreatic Association.
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] IVRとパートナーシップ ―構築と人材育成―2016

    • Author(s)
      齋藤博哉
    • Organizer
      第49回神奈川IVRカンファランス
    • Place of Presentation
      横浜市
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plasma DNA genotyping using digital PCR for early detection of pancreatic cancer; 2nd report (UMIN000012810)2016

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Ando K, Asahara S, Nagashima K.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生分解ステントを留置した先天性総胆管拡張症術後狭窄による肝内胆管結石の1例2016

    • Author(s)
      齋藤博哉、和田玲緒名、前島 拓、唐崎秀則、片田竜司、山北圭介
    • Organizer
      第29回北日本インターベンショナルラジオロジー研究会
    • Place of Presentation
      秋田市
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plasma DNA genotyping using digital PCR; Novel diagnostic tool for early detection of pancreatic cancer2016

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Koizumi K, Asahara S, Maguchi H.
    • Organizer
      Joint Conference of JPS&IAP&AOPA 2016
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Precise Tracing of IPMN-related carcinoma; Defining the Molecular Underpinnings of Distinct Routes to Invasive Carcinomas of the Pancreas.2016

    • Author(s)
      Omori Y, Takahashi K, Karasaki H, Mizukami Y, Maguchi H.
    • Organizer
      Joint Conference of JPS&IAP&AOPA 2016
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plasma DNA genotyping using digital PCR for early detection of pancreatic neoplasm2015

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Ogata M, Koizumi K, Ando K, Yokochi T, Yamada M, Kono T, Nagashima K
    • Organizer
      6th Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      San Diego
    • Year and Date
      2015-11-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Plasma DNA genotyping using digital PCR for early detection of pancreatic neoplasm2015

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Asahara S, Ando K, Shinohara T, Nagashima K
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 液体生検による膵癌リスク評価2015

    • Author(s)
      水上裕輔、真口宏介、小泉一也
    • Organizer
      第23回日本消化器関連学会週間
    • Place of Presentation
      東京
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Book] 図説 胆道IVR 経皮インターベンションのすべて2015

    • Author(s)
      吉岡哲也(著者代表)
    • Total Pages
      256
    • Publisher
      メディカルビュー社
    • Related Report
      2014 Research-status Report
  • [Remarks] 札幌東徳洲会病院付属臨床研究センター

    • URL

      http://www.higashi-tokushukai.or.jp/clinical_study/research/detail.php?pid=581306511139

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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