Cryo-immunology; booster effects of cryotherapy on the anti-tumor immune response
| Project/Area Number |
26670305
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital |
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Principal Investigator |
Saito Hiroya 医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, がん研究部, 副部門長 (80524769)
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| Co-Investigator(Kenkyū-buntansha) |
水上 裕輔 医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, がん研究部, 部門長 (30400089)
田村 保明 北海道大学, 産学・地域協働推進機構, 特任教授 (80322329)
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| Research Collaborator |
Nabeel Bardeesy Massachusetts General Hospital Cancer Center, Associate Professor
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Cryotherapy / IVR / がん / 凍結治療 / Cryo-immunology / 悪性腫瘍 / 凍結療法 / がん凍結治療 |
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| Outline of Final Research Achievements |
Cryotherapy (also called cryosurgery) is a treatment that uses extremely cold temperature to freeze and destroy cancer tissue. Although mainly employed in cases of prostate cancer, the therapeutic option can be used to treat a number of different types of cancer. Curiously, distant and untreated sites of disease can also be regressed after freezing a primary lesion, suggesting cryotherapy may stimulate an anti-tumor immune response. Given the tremendous potential of the local therapy that could also have systemic benefits, we sought to validate the ability of cryotherapy to stimulate a tumor recognition using allograft mouse pancreatic cancer system as a pre-clinical model. The tumor bearing animals treated by cryotherapy decreased growth of either primary or secondary tumor (an imaginary metastasis) relative to the controls. Cryotherapy offers an option for treating cancers that do not respond to standard treatments, and more studies are needed to determine the long-term effects.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Tracking the clonal evolution of adenosquamous carcinoma, a rare variant of intraductal papillary mucinous neoplasm of the pancreas2016
Author(s)
Matsuzaka S, Karasaki H, Ono Y, Ogata M, Oikawa K, Tamakawa S, Chiba S, Muraki M, Yokochi T, Funakoshi H, Kono T, Nagashima K, Mizukami Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation.2015
Author(s)
Tanaka T, Kajiwara T, Kutomi G, Kutomi G, Kurotaki T, Saito K, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y.
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Journal Title
Immunol Lett
Volume: 167
Issue: 1
Pages: 34-40
DOI
Related Report
Peer Reviewed
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[Journal Article] Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.2015
Author(s)
Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y.
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Journal Title
Eur. J Immunology
Volume: 0
Issue: 7
Pages: 0-0
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Cancer-associated oxidase ERO1-α regulates the expression of MHC class I molecule via oxidative folding.2015
Author(s)
Kazuharu Kukita, Yasuaki Tamura, Tsutomu Tanaka, Toshimitsu Kajiwara, Goro Kutomi, Keita Saito, Koichi Okuya, Akari Takaya, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Tomohisa Furuhata, Koichi Hirata, Noriyuki Sato
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Journal Title
J Immunology
Volume: 197
Issue: 10
Pages: 0-0
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells2015
Author(s)
Tsutomu Tanaka, Koichi Okuya, Goro Kutomi, Akari Takaya, Toshimitsu Kajiwara, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
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Journal Title
Cancer Science
Volume: 106
Issue: 1
Pages: 18-24
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] MOLECULAR TRACING OF INVASIVE IPMN LESIONS AND RELATED ADENOCARCINOMA TO DEFINE DISTINCT ROUTES TO INVASIVE CARCINOMAS OF THE PANCREAS.2016
Author(s)
no Y, Omori Y, Takahashi K, Ambo Y, Shinohara T, Nishihara H, Tanaka S, Maguchi H, Karasaki H, Mizukami Y.
Organizer
2016 Annual Meeting - American Pancreatic Association.
Place of Presentation
Boston, USA
Year and Date
2016-10-26
Related Report
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[Presentation] LIQUID BIOPSY FOR EARLY DETECTION OF PANCREATIC CANCER.2016
Author(s)
Mizukami Y, Ono Y, Karasaki H, Ogata M, Sugitani A, Koizumi K, Asahara S, Kawakubo K, Takahashi K, Maguchi H, Nagashima K.
Organizer
2016 Annual Meeting - American Pancreatic Association.
Place of Presentation
Boston, USA
Year and Date
2016-10-26
Related Report
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