Risk factors for cognitive impairment by brain MRI: a population-based cohort
Project/Area Number |
26670307
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
吉村 典子 東京大学, 医学部附属病院, 特任教授 (60240355)
阿久根 徹 国立障害者リハビリテーションセンター(研究所), 病院, 副院長 (60282662)
岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
庄島 正明 東京大学, 医学部附属病院, 特任講師 (80376425)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 認知症 / VSRAD / コホート / MRI / 医療・福祉 / 老化 / 疫学 |
Outline of Final Research Achievements |
In this cohort study for cognitive impairment, 1690 subjects were enrolled. Prevalence of mild cogitive impairment (MCI) was 4.5% (5.1% and 4.2% in men and women, respectively), and was significantly assoiated with age. Brain atrophy measured by VSRAD was signifiantly associated with MMSe score in women (p=0.0027). In addition, the follow-up stuy has been alreadly completed.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study2017
Author(s)
Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study.2017
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M.
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Journal Title
Osteoarthritis Cartilage
Volume: 印刷中
Issue: 7
Pages: 1122-1131
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Serum Levels of Matrix Metalloproteinase-3 and Autoantibodies Related to 2 Rheumatoid Arthritis in the General Japanese Population and their Association with Osteoporosis and Osteoarthritis: The ROAD Study2017
Author(s)
Kodama R, Muraki S, Iidaka T, Oka H, Teraguhi M, Kagotani R, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.
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Journal Title
J Bone Miner Metab
Volume: in press
Issue: 2
Pages: 246-253
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study2017
Author(s)
Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M
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Journal Title
Eur Spine J
Volume: in press
Issue: 10
Pages: 2529-2535
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study.2016
Author(s)
Kodama R, Muraki S, Oka H, Iidaka T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N.
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Journal Title
Mod Rheumatol
Volume: 26
Issue: 5
Pages: 767-773
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.2016
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
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Journal Title
PLoS One
Volume: 11
Issue: 2
Pages: e0147565-e0147565
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Association between the Cross-Sectional Area of the Dural Sac and Low Back Pain in a Large Population: The Wakayama Spine Study.2016
Author(s)
Iwahashi H, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
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Journal Title
PLoS One
Volume: 11
Issue: 8
Pages: e0160002-e0160002
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study.2016
Author(s)
Teraguchi M, Samartzis D, Hashizume H, Yamada H, Muraki S, Oka H, Cheung JP, Kagotani R, Iwahashi H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Cheung KM, Yoshimura N, Yoshida M.
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Journal Title
PLoS One
Volume: 11
Issue: 9
Pages: e0160111-e0160111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD Study2016
Author(s)
Kodama R, Muraki S, Oka H, Iidaka T, Teraguhi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N.
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Journal Title
Modern Rheum
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study.2015
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
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Journal Title
J Bone Miner Metab
Volume: 33
Issue: 2
Pages: 186-191
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study.2015
Author(s)
Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
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Journal Title
J Bone Miner Metab
Volume: 33
Issue: 2
Pages: 221-229
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study.2015
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
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Journal Title
Clin Rheumatol.
Volume: 34
Issue: 9
Pages: 1589-1597
DOI
Related Report
Peer Reviewed
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[Journal Article] The association of combination of disc degeneration, endplate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study2015
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Nakagawa H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
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Journal Title
Spine J
Volume: 15
Issue: 4
Pages: 622-628
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Joint space narrowing, body mass index and knee pain: The ROAD study.2015
Author(s)
Muraki S, Akune T, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N
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Journal Title
Osteoarthritis Cartilage
Volume: 23
Issue: 6
Pages: 874-881
DOI
Related Report
Peer Reviewed
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[Journal Article] Urinary 8-iso-prostaglandin F2a as a marker of metabolic risks in the general Japanese population: The ROAD study.2015
Author(s)
Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Takeshita T
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Journal Title
Obesity 23:1517-1524, 2015.
Volume: 23
Issue: 7
Pages: 1517-1524
DOI
Related Report
Peer Reviewed
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[Journal Article] Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: The ROAD study.2015
Author(s)
Muraki S, Akune T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
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Journal Title
BMC musculoskeltal disorders
Volume: 16
Issue: 1
Pages: 305-305
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Does Osteophytosis at the Knee Predict Health-related Quality of Life Decline? A 3-Year Follow-up of the ROAD Study2015
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
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Journal Title
Clin Rheumatol
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Prevalence and progression of the radiographic ossification of posterior longitudinal ligament and its associated factors in the Japanese populations: A 3-year follow-up of the ROAD study.2014
Author(s)
Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
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Journal Title
Osteoporos Int
Volume: 25
Issue: 3
Pages: 1089-1098
DOI
Related Report
Peer Reviewed
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[Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study.2014
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
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Journal Title
Osteoarthritis Cartilage
Volume: 22
Issue: 1
Pages: 104-110
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: the ROAD study.2014
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
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Journal Title
Mod Rheumatol.
Volume: 24
Issue: 6
Pages: 966-973
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study: The Wakayama Spine Study.2014
Author(s)
52. Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
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Journal Title
Spine J
Volume: in press
Issue: 12
Pages: 2811-2817
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women : The Longitudinal Cohorts of Motor System Organ (LOCOMO) study2013
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
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Journal Title
J Bone Miner Metab
Volume: 32
Issue: 5
Pages: 524-532
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] サルコペニアの疫学2015
Author(s)
村木重之
Organizer
日本骨形態計測学会
Place of Presentation
倉敷市芸文館(岡山県・倉敷市)
Year and Date
2015-06-04
Related Report
Invited
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