Prevention of chronic pain using inflammation and other biomarkers

• Project/Area Number: 26670309
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Niigata University
• Principal Investigator: NAKAMURA Kazutoshi 新潟大学, 医歯学系, 教授 (70207869)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 慢性疼痛 / C反応性タンパク / 生活習慣 / コホート研究 / 炎症 / 認知

Outline of Final Research Achievements

The aim of the study was to explore inflammation and other biomarkers of chronic pain in a cohort study. Blood C-reactive protein (CRP), 25-hydroxyvitamin D (25[OH]D), and items of the clinical laboratory test were measured, and their associations with chronic pain were tested. Blood 25(OH)D concentration was significantly, inversely associated with the incidence of chronic pain of the lumbar region, although CRP and other markers were not with any chronic pain. Vitamin D may be useful to prevent the low back pain.