| Project/Area Number |
26670313
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 家庭血圧 / 日内変動 / 動脈硬化 / 認知機能 |
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| Outline of Final Research Achievements |
Hypertension is a strong risk factor for stroke and myocardial infarction. Because blood pressure (BP) decreases 10 to 20 % during sleep in general, disappearance of nocturnal BP dipping, as well as BP rising during sleep, has been considered as an independent risk factor for the cardiovascular outcomes. Although measurement of nocturnal BP requires ambulatory BP monitoring device, we clarified that nocturnal BP could be easily measured using a commercially available automatic cuff-oscillometric device with a built-in timer programed to measure BP at 0, 2, and 4 o'clock. We determined sleep BP by analyzing a data of wrist-worn activity sensor, and calculated nocturnal BP change by comparing with mean of evening and morning BP. Because office BP, as well as nocturnal BP change, was affected by several factors such as salt loading, and ambient temperature. repeated measurement of nocturnal BP by the simple way might help to precise assessment of nocturnal BP variations.
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