| Project/Area Number |
26670316
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
Tanigawa Takeshi 順天堂大学, 医学(系)研究科(研究院), 教授 (80227214)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Isao 愛媛大学, 大学院医学系研究科, 教授 (90253781)
MARUYAMA Koutatsu 順天堂大学, 大学院医学研究科, 助教 (20627096)
FURUKAWA Shinya 愛媛大学, 大学院医学系研究科, 准教授 (60444733)
EGUCHI Eri 岡山大学, 大学院医歯薬学総合研究科, 助教 (60635118)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病 / 肝機能 / 観察型疫学研究 / 介入研究 / 肝機能障害 / コホート研究 |
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| Outline of Final Research Achievements |
According to previous findings, we presumed that periodontal disease may cause liver dysfunction through the increase of proinflammatory cytokine. Therefore, we conducted an epidemiological study to find a causal-relationship between periodontal disease and liver function. Our cross-sectional study of general men and women aged 30-79 years showed that lactoferrin levels in gingival crevice fluid was positively associated with serum levels of ALT, AST and ALP (p<0.05). We also conducted a clinical trial to examine a treatment effect of periodontal disease on liver function and found that the treatment have significantly improved serum levels of ALT and gamma-GTP among men (but not women) without drinking habit. Thus, our findings suggested a possible causal-relationship between periodontal disease and liver function.
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