| Project/Area Number |
26670319
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Epidemiology and preventive medicine
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Akiyoshi 慶應義塾大学, 政策・メディア研究科, 特任助教 (00572405)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
TOMITA Masaru 慶應義塾大学, 環境情報学部, 教授 (60227626)
SUGIMOTO Masahiro 慶應義塾大学, 政策・メディア研究科, 特任准教授 (30458963)
|
|---|
| Research Collaborator |
KURIHARA Ayako 慶應義塾大学, 医学部, 助教
HARADA Sei 慶應義塾大学, 医学部, 助教
ISHIKAWA Takamasa 慶應義塾大学, 政策・メディア研究科, 特任助教
|
|---|
| Project Period (FY) |
2014-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | バイオマーカー / 代謝プロファイリング / 疫学 / 気分・不安障害 / 睡眠 / メタボローム解析 |
|---|
| Outline of Final Research Achievements |
Mood and anxiety disorder is important issue for population health, and development of effective screening method is sought-after. We compared metabolic profiling of plasma between high- and low- anxiety groups defined by K-6 score in a baseline survey of a population-based cohort study with CE/MS method. Out of 115 metabolites, 5 metabolites for male and 6 for female were significantly related to high K-6 score. I addition, metabolic profiling was compared between insomnia and normal sleep evaluated by Athens Insomnia Scale, but no significant result was observed. Further follow-up as well as detailed pathway analysis are to be done to elucidate causality.
|
