Plasma Na natriuretic peptide is increased risk of carotid atherosclerosis in a Japanese urban population

• Project/Area Number: 26670320
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KOKUBO YOSHIHIRO 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 潜在性心不全 / 頸動脈エコー検査 / 疫学研究 / 血漿Na利尿ペプチド / 頸動脈エコー / 疫学 / ナトリウム利尿ペプチド / 頸動脈硬化

Outline of Final Research Achievements

A total of 3239 participants (30-84 years old) were measured the plasma hANP (human atrial natriuretic peptide) and BNP (Brain natriuretic peptide) levels in the Suita Study. We defined hANP 43 pg/mL or more levels as high hANP and BNP 100 pg/mL or more levels as high BNP. Compared with BNP <100 pg/mL, relative risk (95% confidence intervals) of maximum intimal medial thickness 1.7 mm or more levels in BNP 100 pg/mL or more levels was 1.28 (1.01 to 1.61) by adjusting for age and sex, and 1.27 (1.01 to 1.60) by adjusting for age, sex, smoking, drinking, hypertension, hypercholesterolemia, diabetes mellitus, and body mass index. However, there is no association between hANP and internal medial thickness.

Research Products

• [Journal Article] Impact of hypertension on the lifetime risk of coronary heart disease (2016)
  • Author(s): Chowdhury Turin T, Okamura T, Raheen Afzal A, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
  • Journal Title: Hypertens Res Volume: ２３ Issue: 7 Pages: 548-51
  • DOI: 10.1038/hr.2016.23
  • Peer Reviewed
• [Journal Article] High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study. (2016)
  • Author(s): Yokota C, Sawamura T, Watanabe M, Kokubo Y, Fujita Y, Kakino A, Nakai M, Toyoda K, Miyamoto Y, Minematsu K.
  • Journal Title: J Atheroscler Thromb Volume: ３９
  • NAID: 130005598268
  • Peer Reviewed
• [Journal Article] Hypertension and lifetime risk of stroke (2016)
  • Author(s): Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y
  • Journal Title: J Hypertens Volume: ３４ Issue: 1 Pages: 116-22
  • DOI: 10.1097/hjh.0000000000000753
  • Peer Reviewed
• [Journal Article] Does the utilization of dental services associate with masticatory performance in a Japanese urban population?: the Suita study. (2016)
  • Author(s): Kikui M, Ono T, Kida M, Kosaka T, Yamamoto M, Yoshimuta Y, Yasui S, Nokubi T, Maeda Y, Kokubo Y, Watanabe M, Miyamoto Y.
  • Journal Title: Clin Exp Dent Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Impact of renal function deterioration on adverse events during anticoagulation therapy using non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. (2016)
  • Author(s): Miyamoto K, Aiba T, Arihiro S, Watanabe M, Kokubo Y, Ishibashi K, Hirose S, Wada M, Nakajima I, Okamura H, Noda T, Nagatsuka K, Noguchi T, Anzai T, Yasuda S, Ogawa H, Kamakura S, Shimizu W, Miyamoto Y, Toyoda K, Kusano K.
  • Journal Title: Heart Vessels Volume: (in press) Issue: 8 Pages: 1327-1336
  • DOI: 10.1007/s00380-015-0725-6
  • Peer Reviewed
• [Journal Article] Effect of plasma fibrinogen, high sensitive C reactive protein, and cigarette smoking on carotid atherosclerosis: The Suita Study. (2015)
  • Author(s): Kawase Ishihara K, Kokubo Y, Yokota C, Hida Eisuke, Miyata T, Toyoda K, Matsumoto M, Minematsu K, Miyamoto Y.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 24 Issue: 10 Pages: 2385-9
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.06.039
  • Peer Reviewed
• [Journal Article] Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. (2015)
  • Author(s): Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, Watanabe T, Okamura T, Okayama A, Miyamoto Y.
  • Journal Title: Am J Hypertens. Volume: 28 Issue: 11 Pages: 1355-61
  • DOI: 10.1093/ajh/hpv038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Higher blood pressure as a risk factor for diseases other than stroke and ischemic heart disease. (2015)
  • Author(s): Kokubo Y, Iwashima Y.
  • Journal Title: Hypertension Volume: 66 Issue: 2 Pages: 254-9
  • DOI: 10.1161/hypertensionaha.115.03480
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The new oral anticoagulants (NOAC) study in the ideal and the real world &#8211; Needs of prospective observational studies. (2015)
  • Author(s): Kokubo Y
  • Journal Title: Circ J Volume: 79 Pages: 962-3
  • NAID: 130005066285
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] New Oral Anticoagulants (NOAC) Studies in the Ideal and the Real World – Needs of Prospective Observational Studies – (2015)
  • Author(s): Kokubo Y.
  • Journal Title: Circulation Journal Volume: 79 Issue: 5 Pages: 962-963
  • DOI: 10.1253/circj.CJ-15-0326
  • NAID: 130005066285
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. (2015)
  • Author(s): Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, Watanabe T, Okamura T, Okayama A, Miyamoto Y.
  • Journal Title: Am J Hypertens.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The reasonable reliability of a self-administered food frequency questionnaire for an urban, Japanese, middle-aged population: the Suita study. (2015)
  • Author(s): Maruyama K, Kokubo Y, Yamanaka T, Watanabe M, Iso H, Okamura T, Miyamoto Y.
  • Journal Title: Nutr Res. Volume: 1 Issue: 1 Pages: 14-22
  • DOI: 10.1016/j.nutres.2014.10.012
  • Peer Reviewed
• [Journal Article] Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study. (2014)
  • Author(s): Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, Yamamoto M, Watanabe M, Amano A, Maeda Y, Miyamoto Y.
  • Journal Title: Atherosclerosis. Volume: 237(1) Issue: 1 Pages: 123-8
  • DOI: 10.1016/j.atherosclerosis.2014.08.046
  • Peer Reviewed
• [Presentation] Incidence Rate of Transient Ischemic Attack and Subsequent Stroke Incidence Rates: a Meta-analysis (2016)
  • Author(s): Kokubo Y, Matsumoto C
  • Organizer: International Stroke Conference
  • Place of Presentation: Los Angels
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] Prediction of All-cause and Stroke Mortalities by Carotid Intima-media Thickness in a General Population With a 13.7-year Follow-up: the Suita Study. (2016)
  • Author(s): .Kokubo Y, Watanabe M, Higashiyama A, Watanabe T, Miyamoto Y
  • Organizer: International Stroke Conference
  • Place of Presentation: Los Angels
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] Differences in Stroke Rates and Risk Factors among Western and Asian Countries (2015)
  • Author(s): Kokubo Y, Matsumoto C
  • Organizer: ICNE2015
  • Place of Presentation: Great Coast
  • Year and Date: 2015-11-17
  • Int'l Joint Research / Invited
• [Presentation] Risk Score for the Prediction of Atrial Fibrillation in the Japanese Community: The Suita Study (2015)
  • Author(s): .Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Watanabe T, Takegami M, Kusano K, Kamakura S, Miyamamo Y
  • Organizer: American Heart Association: Scientific Session 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Insulin Resistance and Cardiovascular Events in a General Urban Cohort: The Suita Study. (2015)
  • Author(s): Kokubo Y, Watanabe M, Aya Higashiyama, Nakao YM, Watanabe T, Miyamoto Y.
  • Organizer: ESC2015
  • Place of Presentation: London
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Overweight and metabolic syndrome associated with stroke in Japanese population (2015)
  • Author(s): Kokubo Y
  • Organizer: The 40th Annual Meeting of the Japanese Stroke Society
  • Place of Presentation: Hiroshima
  • Year and Date: 2015-03-26 – 2015-03-29
  • Invited
• [Presentation] Updates on stroke epidemiology in Japan (2014)
  • Author(s): Kokubo Y
  • Organizer: The 4th International Conference on Neurology & Epidemiology
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2014-11-06 – 2014-11-08
  • Invited
• [Presentation] A Combination of Metabolic Syndrome Components Increased the Risk of Incident Atrial Fibrillation in a General Urban Cohort: the Suita Study (2014)
  • Author(s): Kokubo Y, Kobayashi T, Watanabe M, Kamakura S, Kusano K, Kawanishi K, Miyamoto Y.
  • Organizer: High Blood Pressure Research 2014, Scientific Sessions of American Heart Association
  • Place of Presentation: San Francisco, CA, U.S.A.
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] Combination of type 2 diabetes and overweight is linked to an increased incidence of atrial fibrillation in a general urban cohort population (2014)
  • Author(s): Kokubo Y, Kobayashi T, Watanabe M, Kamakura S, Kusano K, Kawanishi K, Miyamoto Y.
  • Organizer: The European Society of Cardiology Congress 2014.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Combined effect of systolic blood pressure and proteinuria on the risk of incident atrial fibrillation in an urban japanese cohort: the suita study (2014)
  • Author(s): Kokubo Y, Watanabe M, Kobayashi T, Kusano K, Kamakura S, Kawanishi K, Miyamoto Y.
  • Organizer: Hypertension 2014: International Society of Hypertension
  • Place of Presentation: Athens, Greece
  • Year and Date: 2014-06-13 – 2014-06-16
• [Presentation] 都市部における脳卒中の大規模コホート (2014)
  • Author(s): 小久保喜弘
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-21 – 2014-05-24
  • Invited
• [Presentation] Asian stroke epidemiology (2014)
  • Author(s): Kokubo Y
  • Organizer: European Stroke Conference
  • Place of Presentation: Nice, France
  • Year and Date: 2014-05-06 – 2014-05-09
  • Invited
• [Book] Pathophysiology and Pharmacotherapy of Cardiovascular Disease (2015)
  • Author(s): Kokubo Y, Iwashima Y, Kamide K
  • Total Pages: 1200
  • Publisher: Springer
• [Book] Hypertension: Introduction, Types, Causes, and Complications (2015)
  • Author(s): Kokubo Y, Iwashima Y, Kamide K.
  • Total Pages: 19
  • Publisher: Springer