• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Plasma Na natriuretic peptide is increased risk of carotid atherosclerosis in a Japanese urban population

Research Project

Project/Area Number 26670320
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

KOKUBO YOSHIHIRO  国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords潜在性心不全 / 頸動脈エコー検査 / 疫学研究 / 血漿Na利尿ペプチド / 頸動脈エコー / 疫学 / ナトリウム利尿ペプチド / 頸動脈硬化
Outline of Final Research Achievements

A total of 3239 participants (30-84 years old) were measured the plasma hANP (human atrial natriuretic peptide) and BNP (Brain natriuretic peptide) levels in the Suita Study. We defined hANP 43 pg/mL or more levels as high hANP and BNP 100 pg/mL or more levels as high BNP. Compared with BNP <100 pg/mL, relative risk (95% confidence intervals) of maximum intimal medial thickness 1.7 mm or more levels in BNP 100 pg/mL or more levels was 1.28 (1.01 to 1.61) by adjusting for age and sex, and 1.27 (1.01 to 1.60) by adjusting for age, sex, smoking, drinking, hypertension, hypercholesterolemia, diabetes mellitus, and body mass index. However, there is no association between hANP and internal medial thickness.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2016 2015 2014

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 5 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Book (2 results)

  • [Journal Article] Impact of hypertension on the lifetime risk of coronary heart disease2016

    • Author(s)
      Chowdhury Turin T, Okamura T, Raheen Afzal A, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
    • Journal Title

      Hypertens Res

      Volume: 23 Issue: 7 Pages: 548-51

    • DOI

      10.1038/hr.2016.23

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study.2016

    • Author(s)
      Yokota C, Sawamura T, Watanabe M, Kokubo Y, Fujita Y, Kakino A, Nakai M, Toyoda K, Miyamoto Y, Minematsu K.
    • Journal Title

      J Atheroscler Thromb

      Volume: 39

    • NAID

      130005598268

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension and lifetime risk of stroke2016

    • Author(s)
      Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y
    • Journal Title

      J Hypertens

      Volume: 34 Issue: 1 Pages: 116-22

    • DOI

      10.1097/hjh.0000000000000753

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does the utilization of dental services associate with masticatory performance in a Japanese urban population?: the Suita study.2016

    • Author(s)
      Kikui M, Ono T, Kida M, Kosaka T, Yamamoto M, Yoshimuta Y, Yasui S, Nokubi T, Maeda Y, Kokubo Y, Watanabe M, Miyamoto Y.
    • Journal Title

      Clin Exp Dent Res

      Volume: (in press)

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of renal function deterioration on adverse events during anticoagulation therapy using non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation.2016

    • Author(s)
      Miyamoto K, Aiba T, Arihiro S, Watanabe M, Kokubo Y, Ishibashi K, Hirose S, Wada M, Nakajima I, Okamura H, Noda T, Nagatsuka K, Noguchi T, Anzai T, Yasuda S, Ogawa H, Kamakura S, Shimizu W, Miyamoto Y, Toyoda K, Kusano K.
    • Journal Title

      Heart Vessels

      Volume: (in press) Issue: 8 Pages: 1327-1336

    • DOI

      10.1007/s00380-015-0725-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of plasma fibrinogen, high sensitive C reactive protein, and cigarette smoking on carotid atherosclerosis: The Suita Study.2015

    • Author(s)
      Kawase Ishihara K, Kokubo Y, Yokota C, Hida Eisuke, Miyata T, Toyoda K, Matsumoto M, Minematsu K, Miyamoto Y.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 24 Issue: 10 Pages: 2385-9

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.06.039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study.2015

    • Author(s)
      Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, Watanabe T, Okamura T, Okayama A, Miyamoto Y.
    • Journal Title

      Am J Hypertens.

      Volume: 28 Issue: 11 Pages: 1355-61

    • DOI

      10.1093/ajh/hpv038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Higher blood pressure as a risk factor for diseases other than stroke and ischemic heart disease.2015

    • Author(s)
      Kokubo Y, Iwashima Y.
    • Journal Title

      Hypertension

      Volume: 66 Issue: 2 Pages: 254-9

    • DOI

      10.1161/hypertensionaha.115.03480

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The new oral anticoagulants (NOAC) study in the ideal and the real world &#8211; Needs of prospective observational studies.2015

    • Author(s)
      Kokubo Y
    • Journal Title

      Circ J

      Volume: 79 Pages: 962-3

    • NAID

      130005066285

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] New Oral Anticoagulants (NOAC) Studies in the Ideal and the Real World – Needs of Prospective Observational Studies –2015

    • Author(s)
      Kokubo Y.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 5 Pages: 962-963

    • DOI

      10.1253/circj.CJ-15-0326

    • NAID

      130005066285

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study.2015

    • Author(s)
      Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, Watanabe T, Okamura T, Okayama A, Miyamoto Y.
    • Journal Title

      Am J Hypertens.

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The reasonable reliability of a self-administered food frequency questionnaire for an urban, Japanese, middle-aged population: the Suita study.2015

    • Author(s)
      Maruyama K, Kokubo Y, Yamanaka T, Watanabe M, Iso H, Okamura T, Miyamoto Y.
    • Journal Title

      Nutr Res.

      Volume: 1 Issue: 1 Pages: 14-22

    • DOI

      10.1016/j.nutres.2014.10.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study.2014

    • Author(s)
      Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, Yamamoto M, Watanabe M, Amano A, Maeda Y, Miyamoto Y.
    • Journal Title

      Atherosclerosis.

      Volume: 237(1) Issue: 1 Pages: 123-8

    • DOI

      10.1016/j.atherosclerosis.2014.08.046

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Incidence Rate of Transient Ischemic Attack and Subsequent Stroke Incidence Rates: a Meta-analysis2016

    • Author(s)
      Kokubo Y, Matsumoto C
    • Organizer
      International Stroke Conference
    • Place of Presentation
      Los Angels
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of All-cause and Stroke Mortalities by Carotid Intima-media Thickness in a General Population With a 13.7-year Follow-up: the Suita Study.2016

    • Author(s)
      .Kokubo Y, Watanabe M, Higashiyama A, Watanabe T, Miyamoto Y
    • Organizer
      International Stroke Conference
    • Place of Presentation
      Los Angels
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences in Stroke Rates and Risk Factors among Western and Asian Countries2015

    • Author(s)
      Kokubo Y, Matsumoto C
    • Organizer
      ICNE2015
    • Place of Presentation
      Great Coast
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Risk Score for the Prediction of Atrial Fibrillation in the Japanese Community: The Suita Study2015

    • Author(s)
      .Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Watanabe T, Takegami M, Kusano K, Kamakura S, Miyamamo Y
    • Organizer
      American Heart Association: Scientific Session 2015
    • Place of Presentation
      Orlando
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin Resistance and Cardiovascular Events in a General Urban Cohort: The Suita Study.2015

    • Author(s)
      Kokubo Y, Watanabe M, Aya Higashiyama, Nakao YM, Watanabe T, Miyamoto Y.
    • Organizer
      ESC2015
    • Place of Presentation
      London
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Overweight and metabolic syndrome associated with stroke in Japanese population2015

    • Author(s)
      Kokubo Y
    • Organizer
      The 40th Annual Meeting of the Japanese Stroke Society
    • Place of Presentation
      Hiroshima
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Updates on stroke epidemiology in Japan2014

    • Author(s)
      Kokubo Y
    • Organizer
      The 4th International Conference on Neurology & Epidemiology
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] A Combination of Metabolic Syndrome Components Increased the Risk of Incident Atrial Fibrillation in a General Urban Cohort: the Suita Study2014

    • Author(s)
      Kokubo Y, Kobayashi T, Watanabe M, Kamakura S, Kusano K, Kawanishi K, Miyamoto Y.
    • Organizer
      High Blood Pressure Research 2014, Scientific Sessions of American Heart Association
    • Place of Presentation
      San Francisco, CA, U.S.A.
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Combination of type 2 diabetes and overweight is linked to an increased incidence of atrial fibrillation in a general urban cohort population2014

    • Author(s)
      Kokubo Y, Kobayashi T, Watanabe M, Kamakura S, Kusano K, Kawanishi K, Miyamoto Y.
    • Organizer
      The European Society of Cardiology Congress 2014.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Combined effect of systolic blood pressure and proteinuria on the risk of incident atrial fibrillation in an urban japanese cohort: the suita study2014

    • Author(s)
      Kokubo Y, Watanabe M, Kobayashi T, Kusano K, Kamakura S, Kawanishi K, Miyamoto Y.
    • Organizer
      Hypertension 2014: International Society of Hypertension
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2014-06-13 – 2014-06-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 都市部における脳卒中の大規模コホート2014

    • Author(s)
      小久保喜弘
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Asian stroke epidemiology2014

    • Author(s)
      Kokubo Y
    • Organizer
      European Stroke Conference
    • Place of Presentation
      Nice, France
    • Year and Date
      2014-05-06 – 2014-05-09
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] Pathophysiology and Pharmacotherapy of Cardiovascular Disease2015

    • Author(s)
      Kokubo Y, Iwashima Y, Kamide K
    • Total Pages
      1200
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Hypertension: Introduction, Types, Causes, and Complications2015

    • Author(s)
      Kokubo Y, Iwashima Y, Kamide K.
    • Total Pages
      19
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi