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An innovative system to investigate HPV vaccine efficacy and increase cervical screening in young women

Research Project

Project/Area Number 26670323
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionHokkaido University

Principal Investigator

Hanley Sharon  北海道大学, 医学研究科, 特任講師 (80529412)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords子宮頸がん / 検診 / HPV / 自己採取HPV検査 / 受診向上 / 検診受診率向上 / 大学生 / HPVワクチン / 子宮頸がん検診率向上 / HPVワクチンの有効性
Outline of Final Research Achievements

Cervical cancer is increasing in Japanese women of reproductive age. Most women who develop cervical cancer are under-screened. This study investigated whether HPV self-sampling (SS) might be an effective means of increasing screening uptake in young Japanese women. It took place in two parts: a feasibility study to examine the acceptability and safety of the SS device in women already attending for screening and a qualitative study investigating the acceptability of the device in women <30yrs of age. Women attending their annual workplace check-up underwent SS followed by a physician-led Pap smear and HPV test. Women found SS significantly less painful, less embarrassing and could relax more (p<0.001). They also found the instructions easy to use. No safety issues were reported. However, in the second study, younger women thought the SS device 'looked liked a syringe' or a 'kitchen utensil' and they preferred a smaller device. Further studies will take place with the smaller device.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Funded Workshop (1 results)

  • [Journal Article] Challenges in breast and cervical cancer control in Japan2016

    • Author(s)
      Hanley SJ, Fujita H, Tamakoshi A, Dong P, Sakuragi N
    • Journal Title

      Lancet Oncology

      Volume: 17(9) Issue: 9 Pages: e372-e372

    • DOI

      10.1016/s1470-2045(16)30411-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HPV self-sampling in Japanese women: A feasibility study in a population with limited experience of tampon use2016

    • Author(s)
      Sharon JB Hanley, Hiromasa Fujita, Susumu Yokoyama, Shiori Kunisawa, Akiko Tamakoshi, Peixin Dong, Noriko Kobayashi, Hidemichi Watari, Masataka Kudo, Noriaki Sakuragi
    • Journal Title

      Journal of Medical Screening

      Volume: 印刷中 Issue: 3 Pages: 164-170

    • DOI

      10.1177/0969141315625702

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 子宮頸がん予防のためのHPVワクチンと自己採取HPV検査の普及が急務2014

    • Author(s)
      Sharon Hanley
    • Journal Title

      Opinion

      Volume: 2 Pages: 45-45

    • Related Report
      2014 Research-status Report
  • [Presentation] 子宮頸がん予防のグローバル戦略:一次予防と 二次予防 -自己採取HPV検査を含めて2016

    • Author(s)
      ハンリー シャロン
    • Organizer
      国際シンポジウム、子宮頸がん予防の戦略:検診とワクチン
    • Place of Presentation
      北海道大学学術交流会館、北海道、札幌市
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Global Trends in Cervical Cancer Prevention: Screening and Vaccination2016

    • Author(s)
      ハンリー シャロン
    • Organizer
      国際シンポジウム、子宮頸がん予防の戦略:検診とワクチン
    • Place of Presentation
      北海道大学フラテホール、北海道、札幌市
    • Year and Date
      2016-03-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] HPV 検査を応用した新しい検診システム導入への取り組み2016

    • Author(s)
      シャロン ハンリー
    • Organizer
      第64回北日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 北海道におけるHPV 検査を応用した新し検診システム導入への取り組み2016

    • Author(s)
      シャロン ハンリー
    • Organizer
      第25回日本婦人科がん検診学会
    • Place of Presentation
      東京慈恵医科大学(東京都港区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Role of HPV Self-Sampling to Increase Cervical Cancer Screening Uptake: A Study on Acceptance, Usability and Clinical Accuracy2015

    • Author(s)
      ハンリー シャロン
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜、神奈川県、横浜市
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] HPV Self-Sampling: A Novel Method to Increase Cervical Screening Uptake in Japanese Women2015

    • Author(s)
      Sharon Hanley
    • Organizer
      第25回日本疫学会学術総会
    • Place of Presentation
      愛知県産業労働センター (名古屋市)
    • Year and Date
      2015-01-23 – 2015-01-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 新たな子宮頸がん検診システムの構策:働く女性の自己採取HPV検査の受容と問題点の検討2014

    • Author(s)
      シャロン ハンリー
    • Organizer
      第66会北海道公衆衛生学会
    • Place of Presentation
      北海道大学 学術交流会館 (札幌市)
    • Year and Date
      2014-12-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 新たな子宮頸がん検診システムの構策:働く女性の自己採取HPV検査の安全性と感度の検討2014

    • Author(s)
      シャロン ハンリー
    • Organizer
      第29回日本女性医学学会学術集会
    • Place of Presentation
      都市センターホテル (東京都)
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Predictors of HPV Self-Sampling Acceptance in Japanese women’ Does History of Tampon use matters2014

    • Author(s)
      Sharon Hanley
    • Organizer
      29th International Papillomavirus Conference
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2014-08-21 – 2014-08-25
    • Related Report
      2014 Research-status Report
  • [Presentation] A Pilot Study Investigating Acceptability of HPV Self-Sampling in Japanese Women of Reproductive Age2014

    • Author(s)
      Sharon Hanley
    • Organizer
      IEA World Congress on Epidemiology
    • Place of Presentation
      Anchorage, Alaska
    • Year and Date
      2014-08-17 – 2014-08-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Comparative Study of Attitudes toward HPV self-sampling and physician-led cervical screening in Japanese women2014

    • Author(s)
      Sharon Hanley
    • Organizer
      Asia Oceania research organisation on Genital Infections and Neoplasia (AOGIN)
    • Place of Presentation
      Peiking, China
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Funded Workshop] 国際シンポジウム、子宮頸がん予防の戦略:検診とワクチンー教育と啓発による女性の認識向上を目指して-2016

    • Place of Presentation
      北海道大学フラテホール、北海道大学学術交流会館、北海道、札幌市
    • Year and Date
      2016-03-15
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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