Associations of psychological factors with obese and metabolic syndrome

• Project/Area Number: 26670334
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Fukushima Medical University
• Principal Investigator: Ohira Tetsuya 福島県立医科大学, 医学部, 教授 (50448031)
• Co-Investigator(Kenkyū-buntansha): YAMAGISHI Kazumasa 筑波大学, 医学医療系, 講師 (20375504) ; KIYAMA Masahiko 公益財団法人大阪府保健医療財団, 大阪がん循環器病予防センター(予防推進部・循環器病・その他部局等), その他 (10450925) ; IMANO Hironori 大阪大学, 医学研究科, 助教 (90450923)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: うつ症状 / メタボリックシンドローム / コホート研究 / 糖尿病 / 前向き研究 / 疫学研究 / 心身連関 / 危険因子

Outline of Final Research Achievements

We sought to examine the association of psychological stress with metabolic syndrome and its factors among community-dwelling men and women.
Cross-sectional and longitudinal studies examined Japanese subjects using data collected from 4,755 participants (1,782 men and 2,973 women) sourced from general health checkups conducted in two communities, Akita and Osaka, between 2007 and 2008. Follow-up examinations were conducted from June 2008 to the end of December 2014. A total of 3,715 participants (1,365 men and 2.350 women, follow-up proportion: 78%) received follow-up examinations, with an average follow-up of 5.4 years. Depressive symptoms were significantly associated with prevalence of diabetes, but not hypertension and dyslipidemia. Longitudinal analyses showed no significant associations of depressive symptoms with metabolic syndrome and its factors.

Research Products

• [Journal Article] Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women (2016)
  • Author(s): Hirokawa K, Ohira T, Nagayoshi M, Kajiura M, Imano H, Kitamura A, Kiyama M, Okada T, Iso H.
  • Journal Title: Psychonueroendcrinology Volume: 69 Pages: 116-122
  • DOI: 10.1016/j.psyneuen.2016.04.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of aroma foot massage on blood pressure and anxiety in Japanese community-dwelling men and women: A crossover randomized controlled trial (2016)
  • Author(s): Eguchi E, Funakubo N, Tomooka K, Ohira T, Ogino K, Tanigawa T.
  • Journal Title: PLoS One Volume: 11 Issue: 3 Pages: e0151712-e0151712
  • DOI: 10.1371/journal.pone.0151712
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Laughter is the best medicine? Cross sectional study of cardiovascular disease among older Japanese adults (2016)
  • Author(s): Hayashi K, Kawachi I, Ohira T, Kondo K, Shirai K, Kondo N
  • Journal Title: J Epidemiol Volume: 26
  • NAID: 130005249196
  • Peer Reviewed / Open Access
• [Journal Article] Drinking Behavior and Mental Illness Among Evacuees in Fukushima Following the Great East Japan Earthquake: The Fukushima Health Management Survey (2016)
  • Author(s): Yuka Ueda, M.A.; Hirooki Yabe, M.D, Ph.D.; Masaharu Maeda, M.D, Ph.D; Tetsuya Ohira, M.D, Ph.D.; Senta Fujii, M.D, Ph.D.; Shin-ichi Niwa, M.D, Ph.D.; Akira Ohtsuru, M.D, Ph.D.; Hirobumi Mashiko, M.D, Ph.D.; Mayumi Harigane, Ph.D.; Seiji Yasumura, M.D, Ph.D.
  • Journal Title: Alcoholism: Clinical and Experimental Research Volume: 40(3) Issue: 3 Pages: 623-630
  • DOI: 10.1111/acer.12984
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effect of evacuation on body weight after the Great East Japan Earthquake (2016)
  • Author(s): Ohira T, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Ozasa K, Kobashi G, Kamiya K, Abe M.
  • Journal Title: Am J Prev Med Volume: 50 Issue: 5 Pages: 553-560
  • DOI: 10.1016/j.amepre.2015.10.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Menopausal status in relation to cardiovascular stress reactivity in healthy Japanese participants. (2014)
  • Author(s): Hirokawa K, Nagayoshi M, Ohira T, Kajiura M, Kitamura A, Kiyama M, Okada T, Iso H.
  • Journal Title: Psychosomatic Medicine Volume: 76 Issue: 9 Pages: 701-708
  • DOI: 10.1097/psy.0000000000000121
  • Peer Reviewed
• [Journal Article] Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS) (2014)
  • Author(s): 6.Iso H, Imano H, Yamagishi K, Ohira T, Cui R, Noda H, Sato S, Kiyama M, Okada T, Hitsumoto S, Tanigawa T, Kitamura A; CIRCS Investigators
  • Journal Title: Atherosclerosis Volume: 237 Issue: 1 Pages: 361-8
  • DOI: 10.1016/j.atherosclerosis.2014.08.028
  • Peer Reviewed
• [Presentation] 笑いと心臓病 (2016)
  • Author(s): 大平哲也
  • Organizer: 第80回日本循環器病学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-20
  • Invited
• [Presentation] 笑いと心臓病との関連についてのエビデンス (2015)
  • Author(s): 大平哲也
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-19
  • Invited
• [Presentation] The effects of laughter yoga program on glycemic control in type 2 diabetes mellitus: a randomized controlled trials (2015)
  • Author(s): Ohira T, Hirosaki M, Wu Y, Nishizawa H, Shimomura I, Iso H
  • Organizer: 29th Conference of the European Health Psychology Society
  • Place of Presentation: Limassol, Cyprus
  • Year and Date: 2015-09-03
  • Int'l Joint Research
• [Presentation] Frequency of laughter and risk of metabolic syndrome components among middle-aged Japanese men and women. (2014)
  • Author(s): Ohira T, Imano H, Cui R, Yamagishi K, Kiyama M, Okada T, Kitamura A, Iso H.
  • Organizer: 20th IEA World Congress of Epidemiology
  • Place of Presentation: Anchorage, AK, USA
  • Year and Date: 2014-08-20
• [Book] 生活習慣是正の指標⑧ ストレス対策・こころの健康． 循環器病予防ハンドブック 第7版 (2014)
  • Author(s): 大平哲也（共著）．日本循環器病予防学会（編）
  • Total Pages: 403
  • Publisher: 保健同人社
• [Remarks] ストレスって何？
  • URL: http://www.fmu.ac.jp/home/epi/recom/recom01.html