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Development of the molecular targeting cancer prevention for diabetics by the activation of TRAIL pathway.

Research Project

Project/Area Number 26670336
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Tomosugi(Horinaka) Mano  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80512037)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがん / 糖尿病 / 予防 / TRAIL / 分子予防 / 免疫
Outline of Final Research Achievements

TRAIL is a cytokine which can induce apoptosis against cancer cells and contribute to cancer prevention. We examined whether the decline of immunity due to diabetes resulted in the down-regulation of TRAIL expression causing subsequent carcinogenesis.
We compared the expression of TRAIL mRNA of the organ samples from a type 2 diabetes model of the rat and mouse with those from normal animals. As the results, TRAIL expressions of cDNA samples derived from large intestine and pancreas of the diabetes model animals were lower than those from normal animals. On the other hand, a diabetes therapeutic drug metformin enhanced the TRAIL sensitivity for several human pancreatic cancer cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.2015

    • Author(s)
      Ryoichi Tanaka, Mitsuhiro Tomosugi, Mano Horinaka, Yoshihiro Sowa, Toshiyuki Sakai.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e0125779-e0125779

    • DOI

      10.1371/journal.pone.0125779

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] メトホルミンはヒト膵癌細胞に対し、miR-221抑制を介したG1期停止作用と、DR5発現誘導を介した TRAIL感受性増強作用を有する2016

    • Author(s)
      堀中真野、田中良一、友杉充宏、曽和義広、酒井敏行
    • Organizer
      第15回分子予防環境医学研究会
    • Place of Presentation
      栃木
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] がんの分子標的予防戦略2015

    • Author(s)
      堀中真野、曽和義広、酒井敏行
    • Organizer
      がん予防学術大会2015
    • Place of Presentation
      さいたま
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Lactobacilli induce TRAIL production in human PBMC and facilitate natural killer activity against cancer cells.2014

    • Author(s)
      Mano Horinaka, Tatsushi Yoshida, Atsuko Kishi, Kaoru Akatani, Takashi Yasuda, Junji Kouhara, Miki Wakada, Toshiyuki Sakai
    • Organizer
      The 5th Asian-Pacific Topic Conference
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 京都府立医科大学 大学院医学研究科 分子標的癌予防医学 ホームページ

    • URL

      http://www.f.kpu-m.ac.jp/k/pubmed/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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