| Project/Area Number |
26670340
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hygiene and public health
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEBAYASHI Toru 慶應義塾大学, 医学部, 教授 (30265780)
KAWASAKI Ryo 山形大学, 医学部, 准教授 (70301067)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Ayano 慶應義塾大学, 医学部, 専任講師 (80511196)
TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
SASAKI Mariko 慶應義塾大学, 医学部, 特任助教 (60276342)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 分子疫学 / メタボローム / 加齢黄斑変性 / メタボロミクス / 眼科疾患 / コホート研究 |
|---|
| Outline of Final Research Achievements |
We planned to link a fundus photo data with a metabolomic profiling data collected from the participants of the cohort study in Tsuruoka. Main target of the analysis was age-related macular degeneration. For the analysis, we used metabolome profiling of 2465 plasma samples and quantified 82 metabolites. The Partial Least Squares Discriminant Analysis revealed beta-alanine for men and malate for women as candidate biomarkers of age-related macular degeneration. However, we could not identify the candidate biomarkers common among men and women.
|
