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Metabolite profiles and age-related macular degeneration

Research Project

Project/Area Number 26670340
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionToho University

Principal Investigator

NISHIWAKI Yuji  東邦大学, 医学部, 教授 (40237764)

Co-Investigator(Kenkyū-buntansha) TAKEBAYASHI Toru  慶應義塾大学, 医学部, 教授 (30265780)
KAWASAKI Ryo  山形大学, 医学部, 准教授 (70301067)
Co-Investigator(Renkei-kenkyūsha) TAKEUCHI Ayano  慶應義塾大学, 医学部, 専任講師 (80511196)
TSUBOTA Kazuo  慶應義塾大学, 医学部, 教授 (40163878)
SASAKI Mariko  慶應義塾大学, 医学部, 特任助教 (60276342)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords分子疫学 / メタボローム / 加齢黄斑変性 / メタボロミクス / 眼科疾患 / コホート研究
Outline of Final Research Achievements

We planned to link a fundus photo data with a metabolomic profiling data collected from the participants of the cohort study in Tsuruoka. Main target of the analysis was age-related macular degeneration. For the analysis, we used metabolome profiling of 2465 plasma samples and quantified 82 metabolites. The Partial Least Squares Discriminant Analysis revealed beta-alanine for men and malate for women as candidate biomarkers of age-related macular degeneration. However, we could not identify the candidate biomarkers common among men and women.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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