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Study on molecular pathology in sudden death due to Excited Delirium

Research Project

Project/Area Number 26670354
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Legal medicine
Research InstitutionTohoku University

Principal Investigator

FUNAYAMA Masato  東北大学, 医学系研究科, 教授 (40190128)

Co-Investigator(Renkei-kenkyūsha) OUCHI Tsukasa  東北大学, 医学系研究科, 技術員 (90712266)
HASHIYADA Masaki  関西医科大学, 医学部, 准教授 (40374938)
Research Collaborator HOSOYA Tadashi  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords興奮性譫妄 / microRNA / 拘束 / 実験モデル / マイクロアレイ / 次世代シークエンス / microNA / 制圧・拘束 / ラット / 心筋 / qRT-PCR / ストレス負荷 / アルコール摂取 / トレッドミル
Outline of Final Research Achievements

MicroRNAs (miRs) are increasingly associated with various diseases and biomechanisms, we studied serum miRs to find physical stress markers.To demonstrate changes in serum and cardiac miR levels when physical stress is applied, we constructed three stress modalities using rats: alcohol intake, treadmill running and restraint. As methods of miR measurement, qRT-PCR was performed after a microarray with serum. In addition, a comprehensive analysis using next-generation sequencing was performed in myocardium. This study showed that there are miRs whose expression level changes due to constraint stress after exercise.It was also suggested that different miRs were expressed depending on the different stress.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Acute Physical Stress Increases Serum Levels of Specific microRNAs2016

    • Author(s)
      Hosoya T, Hashiyada M, Funayama M.
    • Journal Title

      microrna

      Volume: 5 Issue: 1 Pages: 50-56

    • DOI

      10.2174/2211536605666160602104659

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレスモデルラットにおけるmicroRNAの発現変化2016

    • Author(s)
      橋谷田真樹、赤根敦、松本智覧、細谷直、舟山眞人
    • Journal Title

      DNA多型

      Volume: 24 Pages: 218-220

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 死後経過時間に伴うラット血中micro RNA(miRNA)の挙動2015

    • Author(s)
      橋谷田真樹、赤根敦、吉田学、細谷直、舟山眞人
    • Journal Title

      DNA多型

      Volume: 23 Pages: 169-170

    • Related Report
      2015 Research-status Report
  • [Journal Article] 死後経過時間推定マーカーとしてのmicroRNAの評価2014

    • Author(s)
      橋谷田真樹,臼井聖尊,大内 司, 林崎義映,細谷 直,池田知哉, 猪狩 由,荒牧友美, 境 純,舟山眞人
    • Journal Title

      DNA多型

      Volume: 22 Pages: 178-180

    • Related Report
      2014 Research-status Report
  • [Presentation] Acute physical and restraint stress increases miR-16 expression in rat hearts.2014

    • Author(s)
      Hosoya T, Aramaki T, Ikeda T, Igari U, Hayashizak Y, Ohuchi T, Sakai J, Usui K, Hashiyada M, Funayama M.
    • Organizer
      Student Poster Forum. The 98th Congress of the Japanese Society of Legal Medicine. June 16-20, Fukuoka, Japan.
    • Place of Presentation
      Fukuoka (Fukuoka International Congress Center)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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