| Project/Area Number |
26670358
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Kimura Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
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| Co-Investigator(Kenkyū-buntansha) |
KONO TOSHIKAZU 和歌山県立医科大学, 医学部, 教授 (70251923)
ISHIDA YUKO 和歌山県立医科大学, 医学部, 講師 (10364077)
NOSAKA MIZUHO 和歌山県立医科大学, 医学部, 助教 (00244731)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 心腎連関 / IFN-gamma / ANP / apoptosis / 心肥大 / 利尿ペプチド / サイトカイン |
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| Outline of Final Research Achievements |
In this study, we examined the pathogenic role of IFN-gamma in type 1 cardiorenal syndrome in mouse model of transverse aortic constriction (TAC). Severe TAC induced renal injury in IFN-gamma-KO mouse but not in wild-type (WT) mouse, suggesting that IFN-gamma plays a protective role in TAC-induced renal injury (type 1 cardiorenal syndrome). Severe TAC enhanced intracardiac ANP gene expression in WT mice, which was significantly reduced in IFN-gamma-KO mice. ANP infusion significantly attenuated severe TAC-induced renal injury in IFN-gamma-KO mice, indicating that IFN-gamma plays a protective role in type 1 cardiorenal syndrome through enhance of ANP gene expression.
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