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The role of Semaphorin signaling in pathogenesis of obesity and fatty liver -possible implication of gastrointestinal biota.

Research Project

Project/Area Number 26670362
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionChiba University

Principal Investigator

Yokote Koutaro  千葉大学, 医学(系)研究科(研究院), 教授 (20312944)

Co-Investigator(Kenkyū-buntansha) TAKEMOTO Minoru  千葉大学, 大学院医学研究院, 准教授 (60447307)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsセマフォリン / 腸内細菌 / 耐糖能 / 肥満 / 脂肪肝 / 分泌蛋白 / 腸管免疫 / インスリン感受性 / 腸内細菌叢 / Sema3G
Outline of Final Research Achievements

We previously identified a novel secretary Semaphorin, Semaphorin3G (Sema3G), that is expressed in vascular endothelial cells. We then evaluated the roles of Sema3G in gut microbiota and its implication in pathogenesis of the life-style related diseases including obesity and fatty liver disease. Metagenome analysis showed that Sema3G KO gut microbiota included more Bcteroides and less Firmicutes. In addition, Sema3G KO showed more Cyanobacteria and less Verrucomicrobia. Metabolic analysis revealed that Sema3G KO mice showed better glucose tolerance, better insulin sensitivity, and the fatty liver was less severe compared to wild type mice after high fat diet.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (62 results)

All 2016 2015 2014

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 18 results,  Open Access: 20 results,  Acknowledgement Compliant: 3 results) Presentation (37 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.2015

    • Author(s)
      Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 101(3) Issue: 3 Pages: 841-846

    • DOI

      10.1210/jc.2015-2855

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes.2015

    • Author(s)
      Shoji M, Kobayashi K, Takemoto M, Sato Y, Yokote K.
    • Journal Title

      Biomarkers

      Volume: 21(2) Pages: 164-7

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.2015

    • Author(s)
      Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
    • Journal Title

      Sci Rep

      Volume: 30 Issue: 1 Pages: 17565-17565

    • DOI

      10.1038/srep17565

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries.2015

    • Author(s)
      Sakamoto K, Kuno K, Takemoto M, He P, Ishikawa T, Onishi S, Ishibashi R, Okabe E, Shoji M, Hattori A, Yamaga M, Kobayashi K, Kawamura H, Tokuyama H, Maezawa Y, Yokote K
    • Journal Title

      J Diabetes Res

      Volume: 印刷中 Pages: 727152-727152

    • DOI

      10.1155/2015/727152

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns.2015

    • Author(s)
      Matsumoto J, Hirano Y, Numata N, Matzuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      J Eat Disord.

      Volume: 2

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] GERMLINE DELETION OF ARMC5 IN FAMILIAL PRIMARY MACRONODULAR ADRENAL HYPERPLASIA.2015

    • Author(s)
      Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka T.
    • Journal Title

      Endocr Pract.

      Volume: 21 Issue: 10 Pages: 1152-60

    • DOI

      10.4158/ep15756.or

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1.2015

    • Author(s)
      Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T
    • Journal Title

      Cell Rep

      Volume: 12 Issue: 6 Pages: 1042-1055

    • DOI

      10.1016/j.celrep.2015.07.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.2015

    • Author(s)
      Kobayashi K1, Nojiri H2, Saita Y2, Morikawa D1, Ozawa Y3, Watanabe K3, Koike M1, Asou Y4, Shirasawa T5, Yokote K6, Kaneko K2, Shimizu T3.
    • Journal Title

      Scientific Reports

      Volume: Mar 16;5 Issue: 1 Pages: 9148-9148

    • DOI

      10.1038/srep09148

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration2015

    • Author(s)
      Koike, M., Nojiri, H., Ozawa, Y., Watanabe, K., Muramatsu, Y., Kaneko, H., Morikawa, D., Kobayashi, K., Saita, Y., Sasho, T., Shirasawa, T., Yokote, K., Kaneko, K., Shimizu, T.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 11722-11722

    • DOI

      10.1038/srep11722

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of serum antibody levels against TUBB2C with diabetes and cerebral infarction.2015

    • Author(s)
      Hiwasa T, Zhang XM, Kimura R, Machida T, Kitamura K, Yamazoe R, Kunimatsu M, Mine S, Kobayashi E, Iwadate Y, Saeki N, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Iwata Y, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chen PM, Nishi E, Yokota M, Kamitsukasa I, et al.
    • Journal Title

      Gratis J Biomed Sci

      Volume: 1(2) Issue: 2 Pages: 49-63

    • DOI

      10.18314/gjbs.v1i2.27

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus.2015

    • Author(s)
      Goto K, Sugiyama T, Matsumura R, Zhang XM, Kimura R, Taira A, Arita E, Iwase K, Kobayashi E, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, et al
    • Journal Title

      J. Mol. Biomark. Diagnos.

      Volume: 6 Issue: 02 Pages: 2-2

    • DOI

      10.4172/2155-9929.1000219

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pioglitazone improves fat tissue distribution and hyperglycemia in Cockayne syndrome with diabetes.2015

    • Author(s)
      Hayashi A, Takemoto M, Shoji M, Hattori A, Sugita K, Yokote K.
    • Journal Title

      Diabetes Care.

      Volume: 38(5) Issue: 5 Pages: e76-e76

    • DOI

      10.2337/dc14-2944

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astaxantin improved non-alcoholic fatty liver disease in Werner syndrome with diabetes.2015

    • Author(s)
      Takemoto M, Tamaga M, Furuichi Y, Yokote K.
    • Journal Title

      J Am Geriatr Soc.

      Volume: 63(6) Issue: 6 Pages: 1271-1273

    • DOI

      10.1111/jgs.13505

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone (SUCCESS-1): a multicenter, randomized, open-label, non-inferiority trial.2015

    • Author(s)
      Yokoh H, Kobayashi K, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K; SUCCESS Study Group
    • Journal Title

      Journal of Diabetes Invest

      Volume: 6(2) Issue: 2 Pages: 182-191

    • DOI

      10.1111/jdi.12282

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

    • Author(s)
      Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
    • Journal Title

      Leuk Lymphoma.

      Volume: 印刷中 Issue: 10 Pages: 1-4

    • DOI

      10.3109/10428194.2015.1016930

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation in Insulin Receptor Attenuates Oxidative Stress and Apoptosis in Pancreatic Beta-Cells Induced by Nutrition Excess: Reduced Insulin Signaling and ROS.2015

    • Author(s)
      Tachibana K, Sakurai K, Yokoh H, Ishibashi T, Ishikawa K, Shirasawa T, Yokote K.
    • Journal Title

      Horm Metab Res.

      Volume: 47(3) Issue: 03 Pages: 176-183

    • DOI

      10.1055/s-0034-1389990

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice.2015

    • Author(s)
      Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K, Iwama A.
    • Journal Title

      Leuk Lymphoma.

      Volume: 56 Issue: 2 Pages: 520-523

    • DOI

      10.3109/10428194.2014.924120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astaxantin improved non- alcoholic fatty liver disease in Werner syndrome with diabetes.2015

    • Author(s)
      Takemoto M, Yamaga M, Furuichi Y, Yokote K
    • Journal Title

      J Am Geriat Soc

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
  • [Journal Article] Pioglitazone improves fat tissue distribution and hyperglycemia in a case of Cockayne syndrome with diabetes.2015

    • Author(s)
      Hayashi A, Takemoto M, Shoji M, Hattori A, Sugita K, Yokote K.
    • Journal Title

      Diabetes Care

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
  • [Journal Article] Helicobacter cinaedi infection in patients with diabetes: A Case report2015

    • Author(s)
      Ishibashi R, Nakamura S, Takemoto M, Mukai C, Yokote Y
    • Journal Title

      Springerplus

      Volume: - Issue: 1 Pages: 72-72

    • DOI

      10.1186/s40064-015-0863-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes.2015

    • Author(s)
      Maezawa Y, Takemoto M, Yokote K.
    • Journal Title

      J Diabetes Investig

      Volume: 6 Issue: 1 Pages: 3-15

    • DOI

      10.1111/jdi.12255

    • NAID

      120007054435

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with T2DM inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-inferiority trial.2014

    • Author(s)
      Kobayashi K, Yokoh H, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S,Yokote K, on behalf of the SUCCESS Study Group.
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: - Issue: 8 Pages: 761-765

    • DOI

      10.1111/dom.12264

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity.2014

    • Author(s)
      Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5412-5412

    • DOI

      10.1038/srep05412

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is obesity an absolute evil? Increase in adipose tissue does not always decrease insulin sensitivity.2014

    • Author(s)
      Ishikawa K, Yokote K
    • Journal Title

      J Diabetes Investig.

      Volume: 5(3) Issue: 3 Pages: 278-280

    • DOI

      10.1111/jdi.12205

    • Related Report
      2014 Research-status Report
  • [Journal Article] Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas.2014

    • Author(s)
      Oshitari T, Kitahashi M, Mizuno S, Baba T, Kubota-Taniai M, Takemoto M, Yokote K, Yamamoto S, Roy S
    • Journal Title

      BMC Ophthalmol.

      Volume: - Issue: 1 Pages: 31-31

    • DOI

      10.1186/1471-2415-14-31

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Novel treatment to residual risk, K-877, a selective PPAR α modulator(SPPARM α), added-on to stable pitavastatin treatment in Japanese patients with dyslipidemia.2016

    • Author(s)
      横手幸太郎
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Residual riskとしての中性脂肪2016

    • Author(s)
      横手幸太郎
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Treat to target strategy in lipid management for prevention of atherosclerotic vascular diseases.2016

    • Author(s)
      横手幸太郎
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満症に対する内科的治療2016

    • Author(s)
      横手幸太郎
    • Organizer
      第50回日本成人病(生活習慣病)学会学術集会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2016-01-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高齢者糖尿病治療のUPDATE2015

    • Author(s)
      横手幸太郎
    • Organizer
      第30回日本糖尿病合併症学会
    • Place of Presentation
      愛知県産業労働センター ウィンクあいち(愛知県名古屋市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Novel approach to residual risk, K-877, a potent and selective PPAR-α Modulator(SPPARMα), added-on to Pitavastatin in Japanese patients with dyslipidemia.2015

    • Author(s)
      Yokote K, Ishibashi S, Yamashita S, Arai H, Araki E, Suganami H, Kodama T.
    • Organizer
      American Heart Association Scientific Session 2015
    • Place of Presentation
      Orange County Convention Center(Orlando, USA.)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢者における糖尿病治療戦略2015

    • Author(s)
      横手幸太郎
    • Organizer
      第53回日本糖尿病学会東北地方会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Establishment of induced pluripotent stem cells derived from progeroid syndrome.2015

    • Author(s)
      Yokote, K
    • Organizer
      The 10th International Association of Gerontology and Geriatrics- Asia/Oceania 2015
    • Place of Presentation
      The International Convention and Exhibition Center(Chiang Mai, Thailand)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Progeroid syndrome as a model of aging,metabolic diseases and cancer.2015

    • Author(s)
      横手幸太郎
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Targeting obesity in management of diabetes: potential role of incretin-based therapies.2015

    • Author(s)
      Yokote, K
    • Organizer
      The 8th Asia-Oceania Conference on Obesity
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満症の治療と管理2015

    • Author(s)
      横手幸太郎、徳山宏丈
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 超高齢社会の糖尿病治療戦略2015

    • Author(s)
      横手幸太郎
    • Organizer
      第16回日本内分泌学会関東甲信越支部学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diabetes, Obesity and Atherosclerosis.2015

    • Author(s)
      Yokote, K
    • Organizer
      The 15th Taipei International Vascular Biology Symposium Plenary Session
    • Place of Presentation
      台湾大学(台湾、中国)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pitavastatin and Incidence of DM.2015

    • Author(s)
      Yokote, K
    • Organizer
      The Annual Scientific Meeting of Taiwan Society of Lipids & Atherosclerosis 2015
    • Place of Presentation
      台湾大学(台湾、中国)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健康長寿のための肥満症対策2015

    • Author(s)
      横手幸太郎
    • Organizer
      第33回日本肥満症治療学会学術集会
    • Place of Presentation
      幕張国際研修センター(千葉県千葉市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満症の総合的治療戦略2015

    • Author(s)
      横手幸太郎
    • Organizer
      第33回日本肥満症治療学会学術集会
    • Place of Presentation
      幕張国際研修センター(千葉県千葉市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高齢者糖尿病の薬物療法2015

    • Author(s)
      横手幸太郎
    • Organizer
      第29回日本老年学会総会・第57回日本老年医学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂質異常症の観点から2015

    • Author(s)
      横手幸太郎
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂質異常症治療の展望2015

    • Author(s)
      横手幸太郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高齢者糖尿病の病態とその特徴2015

    • Author(s)
      小林一貴、横手幸太郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 北欧留学体験記:学問する文化との出会い2015

    • Author(s)
      横手幸太郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Beyond LDL時代における脂質管理 脂肪酸の役割を含めて2015

    • Author(s)
      横手幸太郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 2型糖尿病への脂質介入Update2015

    • Author(s)
      横手幸太郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満pandemic時代の糖尿病合併症予防~外科治療/SGLT2阻害薬への期待と注意点を含めて~2014

    • Author(s)
      横手幸太郎
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県宮崎市)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 安全かつ有効な肥満症外来治療の方向性:関連学会合同委員会の活動を踏まえて2014

    • Author(s)
      横手幸太郎
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県宮崎市)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Lipid management in diabetes: potential role of pitavastatin in Asian patients.2014

    • Author(s)
      Yokote, K
    • Organizer
      International Conference on Diabetes and Metabolism 2014
    • Place of Presentation
      Kintex Exjhibition Center(Gyeonggi-do,Korea)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Progeroid syndrome as a model of aging-related metabolic disorders.2014

    • Author(s)
      Yokote, K
    • Organizer
      International Conference on Diabetes and Metabolism 2014
    • Place of Presentation
      Kintex Exjhibition Center(Gyeonggi-do,Korea)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Statin in Lipid Management of Diabetes: Effect on Dyslipidemia and Beyond.2014

    • Author(s)
      Yokote, K
    • Organizer
      MSDA2014
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] スタチン投与の適応を検証する2014

    • Author(s)
      横手幸太郎
    • Organizer
      第46回日本動脈硬化学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-07-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 動脈硬化のメカニズム・脳心血管病との関係について2014

    • Author(s)
      横手幸太郎
    • Organizer
      第46回日本動脈硬化学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 日本肥満学会の立場から2014

    • Author(s)
      横手幸太郎
    • Organizer
      第32回日本肥満症治療学会学術集会
    • Place of Presentation
      ピアザ淡海(滋賀県大津市)
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 脂質異常症と認知症2014

    • Author(s)
      横手幸太郎
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢者における糖尿病治療戦略2014

    • Author(s)
      横手幸太郎
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Management of Dyslipidemia for AsianPopulations.2014

    • Author(s)
      Yokote, K.
    • Organizer
      Dyslipidemia in Asia: Clinical Insights & updates 2014,
    • Place of Presentation
      リーガロイヤルホテル(東京都新宿区)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 糖尿病の脂質管理2014

    • Author(s)
      横手幸太郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 指定発言:疾患別項目セットの策定と方向性- 脂質異常症の立場から2014

    • Author(s)
      横手幸太郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Therapeutic Strategy for prevention of atherosclerosis in Diabetes.2014

    • Author(s)
      Yokote, K
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都府京都市)
    • Year and Date
      2014-04-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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