Usefulness of genetic testing with family history taking for personalized preventive medicine

• Project/Area Number: 26670363
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: Yamashita Naohide 東京大学, 医科学研究所, 教授 (90174680)
• Co-Investigator(Kenkyū-buntansha): 渡邉 直 東京大学, 医科学研究所, 助教 (00597271)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: DNA検査 / SNP / レアバリアント / 家族歴 / 個別化予防医療 / 疾患リスク / 個別化医療 / DNA / 家族歴聴取

Outline of Final Research Achievements

In order to investigate the effective method for executing the personalized preventive medicine, genetic testing using SNP information, rare variant information and family history taking was conducted. Rare variants were analyzed using whole genome sequencing. Results of genetic testing was explained to candidates and consulting was done. Before and after genetic testing candidates were asked to answer questionnaires with regard to personalized preventive medicine including understanding of disease and health, and behavior change. Candidates were Asians and Caucasians and it was revealed that understanding of disease and health changed after consulting among Asians.

Research Products

• [Book] 遺伝子検査とわかりやすい疾患の説明 (2017)
  • Author(s): 山下 直秀
  • Total Pages: 458
  • Publisher: よしみ工産株式会社