| Project/Area Number |
26670371
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 健太郎 東京慈恵会医科大学, 医学部, 助教 (30408398)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ボツリヌス毒素A / 脳卒中後痙性片麻痺 / 歩行障害 / 痙縮 / ボツリヌス毒素タイプA / 脳卒中後歩行障害 / 下肢痙縮 / Ａ型ボツリヌス毒素 / 投与方法 / 歩行動作解析 / A型ﾎﾞﾂﾘﾇｽ毒素 |
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| Outline of Final Research Achievements |
The purpose of this study was to examine the effects of combined botulinum toxin type A (BoNT-A)and inpatient multidisciplinary (MD) rehabilitation therapy on the improvement of lower limb function in post-stroke patients.In this retrospective study, a 12-day inpatient treatment protocol was implemented on 51 post-stroke patients with spasticity. Assessments were performed on the day of admission, at discharge, and at 3 months following discharge. At the time of discharge, all of the evaluated items showed a statistically significant improvement. In subgroup analyses, the slowest walking speed group showed a significantly greater change ratio of the 10 Meter Walk Test relative to the other groups, from the time of admission to discharge.Inpatient combined therapy of simultaneous injections of BoNT-A to the upper and lower limbs and MD may improve motor function.
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