| Project/Area Number |
26670372
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGATSU Ikuko 藤田保健衛生大学, 医学部, 名誉教授 (80084573)
NAKAHARA Daiichiro 藤田保健衛生大学, 医学部, 客員教授 (80128389)
USUSA Nobuteru 藤田保健衛生大学, 医学部, 教授 (30135123)
MORIYAMA Yohsuke 藤田保健衛生大学, 医学部, 助教 (00452532)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 灸 / 東洋医学 / 神経伝達物質 / 報酬系 / 統合医療 / EBM / パーキンソン病 / ストレス / c-Fos |
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| Outline of Final Research Achievements |
The mechanism of moxibustion treatment has not been clarified. Some effects of moxibustion may be mediated by the neuronal transmission of the brain with various neurotransmitters. In the present study, moxibustion was applied to rats, and their brains were investigated. Moxibustion induced the dopamine release and c-Fos expression in the mesolimbic dopamine system, and showed a positive preference by the conditioned place preference test, suggesting that moxibustion stimulated the activation of the reward system of rat brain.
In addition, we investigated the possibility of the application of moxibustion for treatments of diseases in which the disorder of neurotransmitters was involved. In 6-OHDA rats which had a shortage of dopamine release, no improvement was shown by moxibustion. In pain-sensitive animals to which naloxone was applied, pain-relative areas of brains were inactivated with moxibustion stimulation, suggesting that moxibustion has a possibility of analgesia.
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