| Project/Area Number |
26670386
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Kato Junji 札幌医科大学, 医学部, 教授 (20244345)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIMONO Risyu 札幌医科大学, 医学部, 准教授 (10336399)
Osuga Takahiro 札幌医科大学, 医学部, 研究員 (40619714)
Okagawa Yutaka 札幌医科大学, 医学部, 研究員 (50722386)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 膵癌 / フコース転移酵素 / digital PCR / liquid biopsy / バイオマーカー |
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| Outline of Final Research Achievements |
It is very useful for the diagnosis of cancer and monitoring of the curative effect if we can rapidly measure protein and a nucleic acid from cancer cell in the peripheral blood with high sensitivity. Numerous fucosylated antigens in sera like CA19-9 serve as tumor markers for pancreatic cancer. We developed a novel pancreatic cancer rapid diagnostic method by the fucosyltransferases mRNA detection in peripheral blood using Droplet Digital PCR (ddPCR).
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