Development of a novel pancreatic cancer rapid diagnostic method by the fucosyltransferases mRNA detection in peripheral blood
Project/Area Number |
26670386
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Sapporo Medical University |
Principal Investigator |
Kato Junji 札幌医科大学, 医学部, 教授 (20244345)
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Co-Investigator(Kenkyū-buntansha) |
TAKIMONO Risyu 札幌医科大学, 医学部, 准教授 (10336399)
Osuga Takahiro 札幌医科大学, 医学部, 研究員 (40619714)
Okagawa Yutaka 札幌医科大学, 医学部, 研究員 (50722386)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 膵癌 / フコース転移酵素 / digital PCR / liquid biopsy / バイオマーカー |
Outline of Final Research Achievements |
It is very useful for the diagnosis of cancer and monitoring of the curative effect if we can rapidly measure protein and a nucleic acid from cancer cell in the peripheral blood with high sensitivity. Numerous fucosylated antigens in sera like CA19-9 serve as tumor markers for pancreatic cancer. We developed a novel pancreatic cancer rapid diagnostic method by the fucosyltransferases mRNA detection in peripheral blood using Droplet Digital PCR (ddPCR).
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer.2015
Author(s)
Sato Y, Ohnuma H, Hirakawa M, Takahashi M, Osuga T, Okagawa Y, Murase K, Takada K, Kawano Y, Iyama S, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kobune M, Okita K, Mizuguchi T, Furuhata T, Hirata K, Kato J
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Journal Title
Cancer Chemother Pharmacol
Volume: 75
Issue: 3
Pages: 587-597
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells2014
Author(s)
Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, Okagawa Y, Uemura N, Arihara Y, Murase K, Kawano Y, Iyama S, Takada K, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
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Journal Title
Gastric Cancer
Volume: 23
Issue: 1
Pages: 85-97
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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