Development of food technology to suppress fibrosis and cancer without affecting liver regeneration.
| Project/Area Number |
26670390
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KOJIMA SOICHI 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別ユニットリーダー (10202061)
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| Co-Investigator(Renkei-kenkyūsha) |
KAJIWARA Susumu 東京工業大学, 生命理工学部, 教授 (10272668)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 内科 / 癌 / 応用微生物 / 食品 / シグナル伝達 |
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| Outline of Final Research Achievements |
Based on the previous findings, we studied molecular mechanisms by which 1-1) a protein crosslinking enzyme, transglutaminase 2 (TG2) promotes cancer angiogenesis and 1-2) co-culture with fungi induces nuclear TG2 activity in hepatic cells, and 2) screened a food-derived compounds that control the above clarified mechanisms. We found 1-1) TG2 inversely regulates the expression of an endogenous angiogenesis inhibitor, vasohibin 1, in lung endothelial cell cultures, animal models, and patients with lung carcinoma, 1-2) C. albicans and C. glabrata but not S. cerevisiae induces increased nuclear TG2 activity in hepatic cells via producing reactive oxygen species, and 2) phenosafranine inhibits nuclear transportation but not activity of TG2. These results suggest phenosafranine will be promising to suppress nuclear TG2-mediated pathogenesis such as cancer angiogenesis and hepatic injury, but not affect cytosolic TG2-mediated physiological role of TG2 such as promotion of tissue remodeling.
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Report
(2 results)
Research Products
(12 results)
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[Journal Article] Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin-4 receptor-deficient mice.2015
Author(s)
Konuma, K., Itoh, M., Suganami, T., Kanai, S., Nakagawa, N., Sakai, T., Kawano, H., Hara, M., Kojima, S., Izumi, Y., and Ogawa, Y.
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Journal Title
Plos One
Volume: 1
Pages: 1-1
Related Report
Peer Reviewed / Open Access
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