| Project/Area Number |
26670393
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Ichiro 東京大学, 医学部附属病院, 講師 (70359628)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIU Katsuhito 東京大学, 医学部附属病院, 特任助教 (30422306)
NAKAYAMA Yukiteru 東京大学, 医学部附属病院, 非常勤医員 (70721885)
SHIBATA Munehiko 東京大学, 医学部附属病院, 非常勤医員 (90646639)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | マクロファージ / 慢性炎症 / 細胞時計 / 心不全 |
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| Outline of Final Research Achievements |
Chronic inflammation is the common pathological basis of noncommunicable diseases, such as cardiovascular and metabolic disease. In chronic inflammation seen in noncommunicable disease, inflammatory processes are not properly resolved, so that low level inflammatory processes continue, resulting in irreversible remodeling of tissues and tissue dysfunction. In the chronic inflammatory processes macrophages function as a key effector cell and exhibit divergent functions and phenotypes. In this project we hypothesized that an endogenous program controls the time-dependent change in macrophage function and that the cellular core clock is liked with that program. Our data suggest the core clock and the inflammatory program interact with each other in macrophages.
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