Elucidation of functional role of gut microbiota in heart failure
Project/Area Number |
26670395
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KOMURO Issei 東京大学, 医学部附属病院, 教授 (30260483)
KAMO Takehiro 東京大学, 医学部附属病院, 特任臨床医 (10722556)
HONDA Kenya 慶應義塾大学, 医学部, 教授 (60334231)
MORITA Hidetoshi 岡山大学, 農学部, 教授 (70257294)
HATTORI Masahira 早稲田大学, 理工学術院, 教授 (70175537)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 心不全 / 腸内細菌叢 / 循環器・高血圧 / 細菌 |
Outline of Final Research Achievements |
To investigate whether gut microbiota in patients with heart failure (HF) is altered, we compared the gut microbiota of HF patients with that of healthy volunteers. Analysis of the bacterial 16S ribosomal RNA gene provided evidence that the number of operational taxonomic units (OTUs) was not different. However, both unweighted and weighted UniFrac analyses showed a significant difference in gut microbiota samples from HF patients and healthy controls. Furthermore, it also showed a significant difference in gut microbiota samples form younger HF patients and older HF patients. These results suggest that gut microbiota is altered in HF patients, and is also influenced by aging, supporting the concept “Heart-Gut axis” that hemodynamic change in HF may induce dysbiosis, and that it may be involved in the progression of HF.
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Congenital Contractural Arachnodactyly without <i>FBN1</i> or <i>FBN2</i> Gene Mutations Complicated by Dilated Cardiomyopathy2015
Author(s)
Yagi H, Hatano M, Takeda N#, Harada S, Suzuki Y, Taniguchi Y, Shintani Y, Morita H, Kanamori N, Aoyama T, Watanabe M, Manabe I, Akazawa H, Kinugawa K, Komuro I.
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Journal Title
Internal Medicine
Volume: 54
Issue: 10
Pages: 1237-1241
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Journal Article] Monitoring beta-arrestin recruitment via beta-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors2015
Author(s)
Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: e0127445-e0127445
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling2015
Author(s)
Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
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Journal Title
PLoS One
Volume: 10
Issue: 5
Pages: e0129394-e0129394
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O.2015
Author(s)
Okada K, Naito AT, Higo T, Nakagawa A, Shibamoto M, Sakai T, Hashimoto A, Kuramoto Y, Sumida T, Nomura S, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Morimoto S, Sakata Y, Shiojima I, Komuro I.
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Journal Title
Circ Heart Fail.
Volume: 8
Issue: 4
Pages: 799-808
DOI
Related Report
Peer Reviewed
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[Journal Article] Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.2015
Author(s)
Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S.
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Journal Title
Metabolism.
Volume: 69
Issue: 9
Pages: 1165-1174
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression.2015
Author(s)
Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I.
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 14453-14453
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload.2015
Author(s)
Yano M, Akazawa H, Oka T, Yabumoto C, Kudo-Sakamoto Y, Kamo T, Shimizu Y, Yagi H, Naito AT, Lee JK, Suzuki J, Sakata Y, Komuro I.
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 15857-15857
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.2015
Author(s)
Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 6241-6241
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Incidence of periodontitis in Japanese patients with cardiovascular diseases: a comparison between abdominal aortic aneurysm and arrhythmia.2014
Author(s)
Suzuki JI, Aoyama N, Aoki M, Tada Y, Wakayama K, Akazawa H, Shigematsu K, Hoshina K, Izumi Y, Komuro I, Miyata T, Hirata Y, Isobe M.
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Journal Title
Heart Vessels
Volume: 掲載確定
Issue: 4
Pages: 498-502
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Post-myocardial Infarction Remodeling Is Involved in the Progression of Calpain-dependent Cleavage of N-cadherin2014
Author(s)
Yoko Kudo-Sakamoto, Hiroshi Akazawa, Kaoru Ito, Jiro Takano, Masamichi Yano, Chizuru Yabumoto, Atsuhiko T. Naito, Toru Oka, Jong-Kook Lee, Yasushi Sakata, Jun-ichi Suzuki, Takaomi C. Saido and Issei Komuro
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Journal Title
The journal of biological chemistry
Volume: 289
Issue: 28
Pages: 19408-19419
DOI
Related Report
Peer Reviewed
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[Journal Article] Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.2014
Author(s)
Sun A, Zou Y, Wang P, Xu D, Gong H, Wang S, Qin Y, Zhang P, Chen Y, Harada M, Isse T, Kawamoto T, Fan H, Yang P, Akazawa H, Nagai T, Ping P, Komuro I, Ge J.
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Journal Title
J Am Heart Assoc
Volume: 3
Issue: 5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Periodontitis in Cardiovascular Disease Patients with or without Marfan Syndrome -A Possible Role of Prevotella intermedia2014
Author(s)
Suzuki J, Imai Y, Aoki M, Fujita D, Aoyama N, Tada Y, Wakayama K, Akazawa H, Izumi Y, Isobe M, Komuro I, Nagai R, Hirata Y.
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Journal Title
Plos One
Volume: epub
Issue: 4
Pages: e95521-e95521
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Excitation propagation in three-dimensional engineered hearts using decellularized extracellular matrix.2014
Author(s)
Yasui H, Lee JK, Yoshida A, Yokoyama T, Nakanishi H, Miwa K, Naito AT, Oka T, Akazawa H, Nakai J, Miyagawa S, Sawa Y, Sakata Y, Komuro I
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Journal Title
Biomaterials
Volume: 35
Issue: 27
Pages: 7839-7850
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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