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Elucidation of functional role of gut microbiota in heart failure

Research Project

Project/Area Number 26670395
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Akazawa Hiroshi  東京大学, 医学部附属病院, 講師 (20396683)

Co-Investigator(Renkei-kenkyūsha) KOMURO Issei  東京大学, 医学部附属病院, 教授 (30260483)
KAMO Takehiro  東京大学, 医学部附属病院, 特任臨床医 (10722556)
HONDA Kenya  慶應義塾大学, 医学部, 教授 (60334231)
MORITA Hidetoshi  岡山大学, 農学部, 教授 (70257294)
HATTORI Masahira  早稲田大学, 理工学術院, 教授 (70175537)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心不全 / 腸内細菌叢 / 循環器・高血圧 / 細菌
Outline of Final Research Achievements

To investigate whether gut microbiota in patients with heart failure (HF) is altered, we compared the gut microbiota of HF patients with that of healthy volunteers. Analysis of the bacterial 16S ribosomal RNA gene provided evidence that the number of operational taxonomic units (OTUs) was not different. However, both unweighted and weighted UniFrac analyses showed a significant difference in gut microbiota samples from HF patients and healthy controls. Furthermore, it also showed a significant difference in gut microbiota samples form younger HF patients and older HF patients. These results suggest that gut microbiota is altered in HF patients, and is also influenced by aging, supporting the concept “Heart-Gut axis” that hemodynamic change in HF may induce dysbiosis, and that it may be involved in the progression of HF.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (55 results)

All 2016 2015 2014

All Journal Article (29 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 29 results,  Acknowledgement Compliant: 7 results,  Open Access: 11 results) Presentation (23 results) (of which Int'l Joint Research: 1 results,  Invited: 12 results) Book (3 results)

  • [Journal Article] Direct left atrial ICE imaging guided ablation for atrial fibrillation without employing contrast medium.2016

    • Author(s)
      Matsubara TJ, Fujiu K, Asada K, et al.
    • Journal Title

      Int J Cardiol

      Volume: 203 Pages: 733-739

    • DOI

      10.1016/j.ijcard.2015.11.038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cacao polyphenols ameliorate autoimmune myocarditis in mice.2016

    • Author(s)
      Zempo H, Suzuki J, Watanabe R, et al.
    • Journal Title

      Hypertens Res

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of murine autoimmune myocarditis achieved with direct renin inhibition.2016

    • Author(s)
      Takamura C, Suzuki J, Ogawa M, et al.
    • Journal Title

      J Cardiol

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac arrest triggered by subepicardial aneurysm without cardiac rupture.2016

    • Author(s)
      Hasumi E, Fujiu K, Imamura T, et al.
    • Journal Title

      Circ J

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure.2016

    • Author(s)
      Watanabe R, Suzuki J, Wakayama K, et al.
    • Journal Title

      Hypertens Res

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 4 signaling plays a critical role in Porphyromonas gingivalis accelerated neointimal formation after arterial injury in mice.2016

    • Author(s)
      Kobayashi N, Suzuki J, Aoyama N, et al.
    • Journal Title

      Hypertens Res

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of endothelial β-catenin signaling induces heart failure.2016

    • Author(s)
      Nakagawa A, Naito AT, Sumida T, et al.
    • Journal Title

      Sci Rep

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging2015

    • Author(s)
      Kano T, Akazawa H, Komuro I
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 3 Pages: 249-254

    • DOI

      10.1536/ihj.14-429

    • NAID

      130005070023

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Congenital Contractural Arachnodactyly without <i>FBN1</i> or <i>FBN2</i> Gene Mutations Complicated by Dilated Cardiomyopathy2015

    • Author(s)
      Yagi H, Hatano M, Takeda N#, Harada S, Suzuki Y, Taniguchi Y, Shintani Y, Morita H, Kanamori N, Aoyama T, Watanabe M, Manabe I, Akazawa H, Kinugawa K, Komuro I.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 10 Pages: 1237-1241

    • DOI

      10.2169/internalmedicine.54.4280

    • NAID

      130005069778

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring beta-arrestin recruitment via beta-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors2015

    • Author(s)
      Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0127445-e0127445

    • DOI

      10.1371/journal.pone.0127445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling2015

    • Author(s)
      Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0129394-e0129394

    • DOI

      10.1371/journal.pone.0129394

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cardiac Non-myocytes in the Hub of Cardiac Hypertrophy.2015

    • Author(s)
      Kamo T, Akazawa H, Komuro I
    • Journal Title

      Circ Res

      Volume: 117 Issue: 1 Pages: 89-98

    • DOI

      10.1161/circresaha.117.305349

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O.2015

    • Author(s)
      Okada K, Naito AT, Higo T, Nakagawa A, Shibamoto M, Sakai T, Hashimoto A, Kuramoto Y, Sumida T, Nomura S, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Morimoto S, Sakata Y, Shiojima I, Komuro I.
    • Journal Title

      Circ Heart Fail.

      Volume: 8 Issue: 4 Pages: 799-808

    • DOI

      10.1161/circheartfailure.114.001958

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure overloaded hearts.2015

    • Author(s)
      Yamagami K, Oka T, Wang Q, et al.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 309 Issue: 3 Pages: 512-522

    • DOI

      10.1152/ajpheart.00137.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.2015

    • Author(s)
      Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S.
    • Journal Title

      Metabolism.

      Volume: 69 Issue: 9 Pages: 1165-1174

    • DOI

      10.1016/j.metabol.2015.05.017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression.2015

    • Author(s)
      Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 14453-14453

    • DOI

      10.1038/srep14453

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload.2015

    • Author(s)
      Yano M, Akazawa H, Oka T, Yabumoto C, Kudo-Sakamoto Y, Kamo T, Shimizu Y, Yagi H, Naito AT, Lee JK, Suzuki J, Sakata Y, Komuro I.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 15857-15857

    • DOI

      10.1038/srep15857

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High incidence and severity of periodontitis in Marfan syndrome patients in Japan.2015

    • Author(s)
      Suzuki J, Imai Y, Aoki M, et al.
    • Journal Title

      Heart Vessels

      Volume: 30 Issue: 5 Pages: 692-695

    • DOI

      10.1007/s00380-013-0434-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis.2015

    • Author(s)
      Arakawa S, Nakanomyo I, Kudo-SakamotoY, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 467 Issue: 4 Pages: 1006-1011

    • DOI

      10.1016/j.bbrc.2015.10.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of Cardiovascular Homeostasis and Pathophysiology – From Gene Expression, Signal Transduction to Cellular Communication –2015

    • Author(s)
      Akazawa H
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 12 Pages: 2529-2536

    • DOI

      10.1253/circj.CJ-15-0818

    • NAID

      130005110902

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.2015

    • Author(s)
      Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 6241-6241

    • DOI

      10.1038/ncomms7241

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A DPP-4 Inhibitor Suppresses Fibrosis and Inflammation on Experimental Autoimmune Myocarditis in Mice2015

    • Author(s)
      Hirata H, Zempo H, Ogawa M, et al
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0119360-e0119360

    • DOI

      10.1371/journal.pone.0119360

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of periodontitis in Japanese patients with cardiovascular diseases: a comparison between abdominal aortic aneurysm and arrhythmia.2014

    • Author(s)
      Suzuki JI, Aoyama N, Aoki M, Tada Y, Wakayama K, Akazawa H, Shigematsu K, Hoshina K, Izumi Y, Komuro I, Miyata T, Hirata Y, Isobe M.
    • Journal Title

      Heart Vessels

      Volume: 掲載確定 Issue: 4 Pages: 498-502

    • DOI

      10.1007/s00380-014-0507-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dickkopf-3: a stubborn protector of cardiac hypertrophy2014

    • Author(s)
      Akazawa H
    • Journal Title

      Cardiovasc Res

      Volume: 102 Issue: 1 Pages: 6-8

    • DOI

      10.1093/cvr/cvu051

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Post-myocardial Infarction Remodeling Is Involved in the Progression of Calpain-dependent Cleavage of N-cadherin2014

    • Author(s)
      Yoko Kudo-Sakamoto, Hiroshi Akazawa, Kaoru Ito, Jiro Takano, Masamichi Yano, Chizuru Yabumoto, Atsuhiko T. Naito, Toru Oka, Jong-Kook Lee, Yasushi Sakata, Jun-ichi Suzuki, Takaomi C. Saido and Issei Komuro
    • Journal Title

      The journal of biological chemistry

      Volume: 289 Issue: 28 Pages: 19408-19419

    • DOI

      10.1074/jbc.m114.567206

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.2014

    • Author(s)
      Sun A, Zou Y, Wang P, Xu D, Gong H, Wang S, Qin Y, Zhang P, Chen Y, Harada M, Isse T, Kawamoto T, Fan H, Yang P, Akazawa H, Nagai T, Ping P, Komuro I, Ge J.
    • Journal Title

      J Am Heart Assoc

      Volume: 3 Issue: 5

    • DOI

      10.1161/jaha.113.000779

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontitis in Cardiovascular Disease Patients with or without Marfan Syndrome -A Possible Role of Prevotella intermedia2014

    • Author(s)
      Suzuki J, Imai Y, Aoki M, Fujita D, Aoyama N, Tada Y, Wakayama K, Akazawa H, Izumi Y, Isobe M, Komuro I, Nagai R, Hirata Y.
    • Journal Title

      Plos One

      Volume: epub Issue: 4 Pages: e95521-e95521

    • DOI

      10.1371/journal.pone.0095521

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excitation propagation in three-dimensional engineered hearts using decellularized extracellular matrix.2014

    • Author(s)
      Yasui H, Lee JK, Yoshida A, Yokoyama T, Nakanishi H, Miwa K, Naito AT, Oka T, Akazawa H, Nakai J, Miyagawa S, Sawa Y, Sakata Y, Komuro I
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 27 Pages: 7839-7850

    • DOI

      10.1016/j.biomaterials.2014.05.080

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High incidence of periodontitis in Japanese patients with abdominal aortic aneurysm2014

    • Author(s)
      Suzuki J, Aoyama N, Aoki M, et al
    • Journal Title

      Int Heart J

      Volume: 55 Pages: 268-270

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Cardiomyocyte Angiotensin II Type 1 Receptor Plays an Integrative Role in Post-myocardial Infarction Remodeling2016

    • Author(s)
      Hiroshi Akazawa, Masamichi Yano, Seitaro Nomura, Issei Komuro
    • Organizer
      Gordon Research Conference on Angiotensin
    • Place of Presentation
      Renaissance Tuscany (Il Ciocco, Italy)
    • Year and Date
      2016-02-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心筋リモデリングにおけるカルパイン・カルパスタチンシステムの機能と役割2015

    • Author(s)
      赤澤 宏
    • Organizer
      Cardiovascular and Metabolic Week 2015 心血管代謝週間
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 老化から疾患を考える~老化促進分子とRASの関係2015

    • Author(s)
      赤澤 宏
    • Organizer
      Cardiovascular and Metabolic Week 2015 心血管代謝週間
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Monocyte-derived Extracellular Nampt-dependent Biosynthesis of Myocardial NAD+ Protects the Heart against Pressure Overload2015

    • Author(s)
      藪本千鶴、赤澤 宏、矢野正道、小室一成
    • Organizer
      Cardiovascular and Metabolic Week 2015 心血管代謝週間
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Monocyte-derived extracellular Nampt-dependent biosynthesis of myocardial NAD+ protects the heart against pressure overload2015

    • Author(s)
      矢野正道、赤澤 宏、藪本千鶴、坂田泰史、小室一成
    • Organizer
      第19回日本心不全学会学術集会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inflammatory network underlying the pathogenesis of atrial fibrillation in stressed hearts2015

    • Author(s)
      赤澤 宏
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 単球由来eNamptによる圧負荷心の恒常性維持機構2015

    • Author(s)
      赤澤 宏
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Monocyte-derived Extracellular Nampt-dependent Biosynthesis of Myocardial NAD+ is Essential for Hemodynamic Compensation to Pressure Overload2015

    • Author(s)
      藪本千鶴、赤澤 宏、矢野正道、小室一成
    • Organizer
      第5回Molecular Cardiovascular Conference II
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inflammatory network underlying the pathogenesis of atrial fibrillation2015

    • Author(s)
      赤澤 宏
    • Organizer
      第30回日本不整脈学会学術大会・第32回日本心電学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 老化形質発現におけるRASとWntの役割2015

    • Author(s)
      赤澤 宏
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 心臓のストレス応答から探る創薬ターゲット2015

    • Author(s)
      赤澤 宏
    • Organizer
      第1回国際心血管薬物療法学会日本部会学術集会
    • Place of Presentation
      ハイアットリージェンシー京都(京都府京都市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 老化形質発現におけるアンジオテンシンII受容体シグナルの多面的役割2015

    • Author(s)
      藪本 千鶴、赤澤 宏、内藤 篤彦、小室 一成
    • Organizer
      Research PlaNet 2014
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-05-10 – 2015-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Molecular Mechanisms of Cardiovascular Stress Responses and Pathophysiology2015

    • Author(s)
      赤澤 宏
    • Organizer
      第79回日本循環器学会学術集
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] New position of β-blockers in cardiovascular medicine2015

    • Author(s)
      赤澤 宏
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都市)
    • Year and Date
      2015-04-14 – 2015-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Angiotensin II receptor blockade down-regulates aging-promoting C1q protein and promotes skeletal muscle regeneration2015

    • Author(s)
      藪本 千鶴、赤澤 宏、矢野 正道、坂本 陽子、内藤 篤彦、 小室 一成
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都市)
    • Year and Date
      2015-04-14 – 2015-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 高血圧治療のUP TO DATE2015

    • Author(s)
      赤澤 宏
    • Organizer
      日本内科学会北陸支部第64回生涯教育講演会
    • Place of Presentation
      石川県地場産業センター(金沢市)
    • Year and Date
      2015-03-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] レニン・アンジオテンシン系の拮抗的多面性と生老病死2014

    • Author(s)
      赤澤 宏
    • Organizer
      第16回旭川心血管リモデリング研究会
    • Place of Presentation
      旭川グランドホテル(旭川市)
    • Year and Date
      2014-10-03
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Prevention of left ventricular remodeling after myocardial infarction is associated with N-cadherin cleavage by calpain2014

    • Author(s)
      坂本 陽子、赤澤 宏、藪本 千鶴、矢野 正道、坂田 泰史、小室 一成
    • Organizer
      第5回Molecular Cardiovascular Conference II
    • Place of Presentation
      神戸ベイシェラトンホテル&タワーズ(神戸市)
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 心筋梗塞後左室リモデリングにおけるアンジオテンシンII受容体の細胞特異的な役割2014

    • Author(s)
      矢野 正道、赤澤 宏、坂本 陽子、藪本 千鶴、坂田 泰史、小室 一成
    • Organizer
      第5回Molecular Cardiovascular Conference II
    • Place of Presentation
      神戸ベイシェラトンホテル&タワーズ(神戸市)
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 老化形質発現におけるレニン・アンジオテンシンII系の多面的役割2014

    • Author(s)
      赤澤 宏
    • Organizer
      お茶の水がん学アカデミア第105回集会
    • Place of Presentation
      順天堂大学医学部(東京都文京区)
    • Year and Date
      2014-06-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 心臓リモデリングと老化・炎症2014

    • Author(s)
      赤澤 宏
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 老化による心血管疾患発症の分子機序2014

    • Author(s)
      赤澤 宏、小室 一成
    • Organizer
      第3回臨床高血圧フォーラム
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 心血管疾患の発症と老化におけるレニン・アンジオテンシン系の多面的役割2014

    • Author(s)
      心血管疾患の発症と老化におけるレニン・アンジオテンシン系の多面的役割
    • Organizer
      第1回腎と血管研究会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Year and Date
      2014-05-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] Annual Review 循環器 20162015

    • Author(s)
      高橋政夫、赤澤 宏、小室一成
    • Total Pages
      280
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 再生医療用語ハンドブック2015

    • Author(s)
      赤澤 宏
    • Total Pages
      333
    • Publisher
      メディカルトリビューン
    • Related Report
      2014 Research-status Report
  • [Book] 高血圧専門医ガイドブック2014

    • Author(s)
      赤澤 宏、小室 一成
    • Total Pages
      249
    • Publisher
      診断と治療社
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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