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Characterization of neural crest cells migrating into the heart

Research Project

Project/Area Number 26670396
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionThe University of Tokyo

Principal Investigator

KURIHARA Hiroki  東京大学, 大学院医学系研究科, 教授 (20221947)

Co-Investigator(Renkei-kenkyūsha) WADA Youichiro  東京大学, アイソトープ総合センター, 教授 (10322033)
TOMITA Sachiko  ヤマザキ学園大学, 動物看護学部, 教授 (40231451)
KURIHARA Yukiko  東京大学, 大学院医学系研究科, 講師 (80345040)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords循環器 / 分子心臓学 / 発生・分化 / 幹細胞
Outline of Final Research Achievements

In this study, we investigated the origin and fate of neural crest cells migrating into the heart through experiments using mouse and avian embryos. We found that cells originating from the preotic region of the neural crest, as well as “cardiac neural crest cells” derived from the more caudal post-otic region, migrate into the heart and differentiate into various cell types including coronary artery smooth muscle cells and mesenchymal cells in the semiluminal valves and myocardial walls. Single-cell analysis of gene expression patterns revealed the existence of a subset of neural crest cells expressing some stem cell markers (e.g. c-Kit), indicating the maintenance of the stemness with multipotency in a neural crest population within the heart.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (42 results)

All 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 13 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (28 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Developmental mechanisms of the tympanic membrane in mammals and non-mammalian amniotes2016

    • Author(s)
      Takechi, M., Kitazawa, T., Hirasawa, T., Hirai, T., Iseki, S., Kurihara, H., Kuratani, S.
    • Journal Title

      Congenital Anomalies

      Volume: 56 Issue: 1 Pages: 12-17

    • DOI

      10.1111/cga.12132

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem.2015

    • Author(s)
      Laumonnerie C, Bechara A, Vilain N, Kurihara Y, Kurihara H,Rijli FM.
    • Journal Title

      Development.

      Volume: 142(21) Pages: 3704-3712

    • DOI

      10.1242/dev.128736

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.2015

    • Author(s)
      Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Neme N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6853-6853

    • DOI

      10.1038/ncomms7853

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.2015

    • Author(s)
      Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H
    • Journal Title

      Developmental Biology

      Volume: 15 Issue: 2 Pages: 162-174

    • DOI

      10.1016/j.ydbio.2015.04.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia.2015

    • Author(s)
      Gordon CT, Weaver KN, Zechi-Ceide RM, Madsen EC, Tavares AL, Oufadem M, Kurihara Y, (18名), Kurihara H, .et al.
    • Journal Title

      Am J Hum Genet.

      Volume: 96(4) Issue: 4 Pages: 519-531

    • DOI

      10.1016/j.ajhg.2015.01.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simple model of pH-induced protein denaturation.2015

    • Author(s)
      Hidaka T, Shimada A, Nakata Y, Kodama H, Kurihara H, Tokihiro T, Ihara S.
    • Journal Title

      Phys Rev E Stat Nonlin Soft Matter Phys.

      Volume: 92(1-1) Pages: 012709-012709

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autonomy and non-autonomy of angiogenic cell movements revealed by experiment-driven mathematical modeling2015

    • Author(s)
      Sugihara K, Nishiyama K, Fukuhara S, Uemura A, Arima S, Kobayashi R, Kohn-Luque A, Mochizuki N, Suda T, Ogawa S, Kurihara H
    • Journal Title

      Cell Rep

      Volume: 13 Issue: 9 Pages: 1814-1827

    • DOI

      10.1016/j.celrep.2015.10.051

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysregulated YAP1/TAZ and TGF signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice2015

    • Author(s)
      Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A.
    • Journal Title

      PNAS

      Volume: 113 Issue: 1 Pages: 71-80

    • DOI

      10.1073/pnas.1517188113

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Postotic and preotic neural crest cells differently contribute to thyroid development.2015

    • Author(s)
      Kazuhiro Maeda, Rieko Asai, Kazuaki Maruyama, Yukiko Kurihara, Toshio Nakanishi, Hiroki Kurihara, Sachiko Miyagawa-Tomita.
    • Journal Title

      Dev Biol

      Volume: 409 Issue: 1 Pages: 72-83

    • DOI

      10.1016/j.ydbio.2015.10.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.2015

    • Author(s)
      Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Nême N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H.
    • Journal Title

      Nat. Commun.

      Volume: 14 Pages: 18224-18224

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysocin e is a new antibiotic that targets menaquinone in the bacterial membrane2015

    • Author(s)
      Hamamoto H, Urai M, Ishii K, Yasukawa J, Paudel A, Murai M, Kaji T, Kuranaga T, Hamase K, Katsu T, Su J, Adachi T, Uchida R, Tomoda H, Yamada M, Souma M, Kurihara H, Inoue M, Sekimizu K.
    • Journal Title

      Nature Chemical Biology

      Volume: 11 Issue: 2 Pages: 127

    • DOI

      10.1038/nchembio.1710

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart2014

    • Author(s)
      Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 4452-4452

    • DOI

      10.1038/ncomms5552

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells2014

    • Author(s)
      Fu H, Wada-Hiraike O, Hirano M, Kawamura Y, Sakurabashi A, Shirane A, Morita Y, Isono W, Oishi H, Koga K, Oda K, Kawana K, Yano T, Kurihara H, Osuga Y, Fujii T.
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 8 Pages: 3079

    • DOI

      10.1210/en.2014-1025

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 血管新生における細胞動態の実験及び数理解析2016

    • Author(s)
      栗原裕基
    • Organizer
      生命動態システム科学四拠点・CREST・PRESTO・QBiC 合同シンポジウム「生命動態の分子メカニズムと数理」
    • Place of Presentation
      広島県広島市
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Semaphorin3E-PlexinD1 シグナルは冠動脈形成に重要な役割を果たす2016

    • Author(s)
      丸山和晃,富田-宮川幸子,有馬勇一郎,浅井理恵子,植村明嘉, 瀬谷大貴,吉田豊, Man Fanny, 栗原由紀子,栗原裕基
    • Organizer
      血管生物医学会 若手研究会
    • Place of Presentation
      宮崎県仙台市
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心溜出路に遊走する神経堤細胞の系譜とレチノイン酸の作用の検討2015

    • Author(s)
      瀬谷大貴、富田-宮川幸子、有馬勇一郎、淺井理恵子、丸山和晃、内島泰信、栗原由紀子、栗原裕基
    • Organizer
      第14回日本心臓血管発生研究会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1シグナルは冠血管発生に重要である2015

    • Author(s)
      丸山和晃,富田-宮川幸子,有馬勇一郎,浅井理恵子,植村明嘉, 瀬谷大貴,吉田豊, Man Fanny, 栗原由紀子,栗原裕基
    • Organizer
      第14回日本心臓血管発生研究会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単一細胞トラッキングを用いた血管内皮細胞動態解析2015

    • Author(s)
      田久保直子,苗村和明,吉田亮,徳永旭将,広瀬修,内島泰信,栗原由紀子,栗原裕基
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス脳底動脈拡張症モデルの作成・解析2015

    • Author(s)
      苗村和明、中冨浩文、田口明糸、和田洋一郎、斉藤延人、栗原裕基苗村和明、中冨浩文、田口明糸、和田洋一郎、斉藤延人、栗原裕基
    • Organizer
      第23回日本血管生物医学回学術集会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1 シグナルは冠動脈形成に重要な役割を果たす2015

    • Author(s)
      丸山和晃,富田-宮川幸子,有馬勇一郎,浅井理恵子,植村明嘉, 瀬谷大貴,吉田豊, Man Fanny, 栗原由紀子,栗原裕基
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] in vitro 血管新生のタイムラプスイメージングと細胞トラッキング2015

    • Author(s)
      田久保直子
    • Organizer
      生命ダイナミクスの数理とその応用:理論からのさらなる深化(数学協働プログラム)
    • Place of Presentation
      東京都文京区
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 形態形成における long noncodingRNA: Evf2の機能解析2015

    • Author(s)
      栗原由紀子
    • Organizer
      第38回日本分子生物学会年会(BMB2015)
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] A homeotic transformation in neural crest-specific Dlx5-overexpressing mice.神経堤細胞特異的Dlx5過剰発現マウスにおける顎顔面のトランスフォーメーション2015

    • Author(s)
      Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Youichiro Wada, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation2015

    • Author(s)
      丸山和晃,富田-宮川幸子,有馬勇一郎,浅井理恵子,植村明嘉, 瀬谷大貴,吉田豊, Man Fanny, 栗原由紀子,栗原裕基
    • Organizer
      第38回日本分子生物学会年会(BMB2015)
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] からだのかたちづくりを科学する2015

    • Author(s)
      栗原裕基
    • Organizer
      生命のダイナミクスと数学 公開講座
    • Place of Presentation
      東京都文京区
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マウス脳底動脈露出手技の確立及びマウス脳底動脈拡張症モデルの作成・解析2015

    • Author(s)
      苗村和明、中冨浩文、宮脇哲、越智崇、伊藤明博、今井英明、栗原裕基、斉藤延人
    • Organizer
      第74回日本脳神経外科学会学術総会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血管新生における内皮細胞動態ライブイメージング2015

    • Author(s)
      田久保直子,苗村和明,吉田亮,徳永旭将,広瀬修,内島泰信,栗原由紀子,栗原裕基
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] A homeotic transformation in Dlx5-overexpressing mice give a hint to form a dorsoventral axis.2015

    • Author(s)
      Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Youichiro Wada, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara
    • Organizer
      第15回東京大学生命科学シンポジウム
    • Place of Presentation
      東京都文京区
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dlx5-overexpression mice show a homeotic transformation in the upper jaw into lower jaw-like structures.Dlx5過剰発現マウスにおける上顎の下顎構造へのトランスフォーメーション2015

    • Author(s)
      Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara
    • Organizer
      第48回日本発生生物学会
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Semaphorin3E-PlexinD1 signaling is important for coronary artery formation2015

    • Author(s)
      丸山和晃,富田-宮川幸子,有馬勇一郎,浅井理恵子,植村明嘉, 瀬谷大貴,吉田豊, Man Fanny, 栗原由紀子,栗原裕基
    • Organizer
      第48回日本発生生物学会
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Independent origins of the tympanic membrane and middle ear in different amniote taxa.2015

    • Author(s)
      Taro Kitazawa, Masaki Takechi, Tatsuya Hirasawa, Nicolas Narboux-Neme, Hideaki Kume, Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Yukiko Kurihara, Giovanni Levi, Shigeru Kuratani, Hiroki Kurihara.
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-05-27 – 2015-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Semaphorin3E-PlexinD1 signalimg is importamt for coronary artery formation2015

    • Author(s)
      Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Yuichiro Arima, Daiki Seya, Rieko Asai, Akiyoshi Uemura, Yutaka Yoshida, Mann Fanny, Yukiko Kurihara, Hiroki Kurihara
    • Organizer
      Weinstein 2015
    • Place of Presentation
      USA ,Boston
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単一細胞ライブイメージングを用いた内皮細胞動態解析2015

    • Author(s)
      田久保直子,内島泰信,金井政宏,苗村和明,栗原由紀子,栗原裕基.
    • Organizer
      生命動態システム科学四拠点・CREST・PREST合同シンポジウム
    • Place of Presentation
      京都府京都市
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of Semaphorin3E-PlexinD1 signaling in heart morphogenesis.2014

    • Author(s)
      Kazuaki Maruyama , Sachiko Miyagawa-Tomita , Yuichiro Arima , Daiki Seya , Rieko Asai , Akiyoshi Uemura , Yutaka Yoshida , Mann Fanny , Yukiko Kurihara , Hiroki Kurihara.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Preotic neural crest cells contribute to thyroid bilobation.2014

    • Author(s)
      Kazuhiro Maeda, Rieko Asai, Hiroki Kurihara, Sachiko Miyagawa-Tomita.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Dlx5-overexpression mice show a homeotic transformation in the upper jaw into lower jaw-like structures.2014

    • Author(s)
      Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] エンドセリン-Dlx5/6遺伝子変異マウスにおけるIRDS様肺病変2014

    • Author(s)
      栗原由紀子、淺井理恵子、河村悠美子、栗栖健、栗原裕基
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 単一細胞ライブイメージングを用いた血管新生の細胞動態解析2014

    • Author(s)
      田久保 直子,苗村 和明,内島 泰信,栗原 由紀子,栗原 裕基.
    • Organizer
      「生命動態の理解と制御のための基盤技術の創出」研究領域 第3回領域会議
    • Place of Presentation
      沖縄県国頭郡
    • Year and Date
      2014-10-28 – 2014-10-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 胚外壁側葉中胚葉は心血管形成に寄与する2014

    • Author(s)
      Rieko Asai, Sachiko Miyagawa-Tomita, Yukiko Kurihara , Hiroki Kurihara.
    • Organizer
      第13回心臓血管発生研究会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Semaphorin3E, PlexinD1の心臓血管系発生における役割の解明2014

    • Author(s)
      Kazuaki Maruyama , Sachiko Miyagawa-Tomita , Yuichiro Arima , Daiki Seya , Rieko Asai , Akiyoshi Uemura , Yutaka Yoshida , Mann Fanny , Yukiko Kurihara , Hiroki Kurihara.
    • Organizer
      第13回心臓血管発生研究会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Homeotic transformation of the upper jaw into lower jaw-like structures in Dlx5-overexpressing mice.2014

    • Author(s)
      Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara.
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京大学大学院医学系研究科 代謝生理化学教室

    • URL

      http://bio.m.u-tokyo.ac.jp/home-j.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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