Development of simple and noninvasive method to assess the severity of heart failure

• Project/Area Number: 26670402
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Osaka University
• Principal Investigator: TAKASHIMA Seiji 大阪大学, 生命機能研究科, 教授 (90379272)
• Co-Investigator(Kenkyū-buntansha): ASANO Yoshgihiro 大阪大学, 医学系研究科 (60527670)
• Co-Investigator(Renkei-kenkyūsha): TSUKAMOTO Osamu 大阪大学, 医学系研究科 (80589151) ; HIGO Shuichiro 大阪大学, 医学系研究科 (00604034)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 心不全 / 利尿ホルモン / モデル動物 / 循環器・高血圧

Outline of Final Research Achievements

Natriuretic peptides (ANP and BNP) are physiologically active substances secreted from the heart during heart failure. Their diuretic function works on the improvement of heart failure. Both ANP and BNP have already been frequently used in clinical heart failure as therapeutic agents. In this study we revealed a mechanism for adjusting the expression of natriuretic peptides in failing heart. At the same time, we developed a technique for quantifying severity of heart failure by utilizing this phenomenon. Establishment of the pathogenesis and treatment of heart failure is expected by the study in the future.

Research Products

• [Journal Article] Higdla is a oositive regulaator of cytochrome c oxidase (2015)
  • Author(s): T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
  • Journal Title: Proc. Nat. Acad. Sci. U.S.A. Volume: 112 Issue: 5 Pages: 1553-1558
  • DOI: 10.1073/pnas.1419767112
  • Peer Reviewed / Open Access
• [Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5. (2015)
  • Author(s): Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S..
  • Journal Title: Nat Commun. Volume: 30 Pages: 6137-6150
  • Peer Reviewed / Open Access / Acknowledgement Compliant