The role of Cavin family proteins in cardiovascular disease
Project/Area Number |
26670407
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Ueyama Tomomi 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (80379388)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | カベオラ / Cavin family / cavin family / シグナル伝達 |
Outline of Final Research Achievements |
PTRF/Cavin-1 deficiency in mice causes loss of caveolae in cardiomyocytes, impaired cardiac function accompanying cardiomyocyte hypertrophy and interstitial fibrosis. MURC deficiency in mice attenuates cardiac hypertrophy induced by α1-adrenergic receptor stimulation and pulmonary hypertension induced by hypoxia. MURC deficiency, on the other hand, exacerbated abdominal aortic aneurysm (AAA) in mice. These results reveals that PTRF/Cavin-1 regulates cardiac function, and that MURC is involved in the development of cardiac hypertrophy, pulmonary hypertension, and AAA.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm2017
Author(s)
13.Miyagawa K, Ogata T, Ueyama T, Kasahara T, Nakanishi N, Naito D, Taniguchi T, Hamaoka T, Maruyama N, Nishi M, Kimura T, Yamada H, Aoki H, Matoba S
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Journal Title
Biochem Biophys Res Commun
Volume: 487
Issue: 3
Pages: 587-593
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MURC deficiency in smooth muscle attenuates pulmonary hypertension2016
Author(s)
11.Nakanishi N, Ogata T, Naito D, Miyagawa K, Taniguchi T, Hamaoka T, Maruyama N, Kasahara T, Nishi M, Matoba S, Ueyama T
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Journal Title
Nat Commun
Volume: 7
Issue: 1
Pages: 12417-12417
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis2016
Author(s)
12.Taniguchi T, Maruyama N, Ogata T, Kasahara T, Nakanishi N, Miyagawa K, Naito D, Hamaoka T, Nishi M, Matoba S, Ueyama T
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Journal Title
PLoS One
Volume: 11
Issue: 9
Pages: e0162513-e0162513
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.2015
Author(s)
8.Naito D, Ogata T, Hamaoka T, Nakanishi N, Miyagawa K, Maruyama N, Kasahara T, Taniguchi T, Nishi M, Matoba S, Ueyama T.
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 309
Issue: 12
Pages: H2127-H2136
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The small molecule BGP-15 protects against heart failure and atrial fibrillation in mice.2014
Author(s)
Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR.
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Journal Title
Nat Commun.
Volume: 5
Pages: 5705-5705
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors.2014
Author(s)
Ogata T, Naito D, Nakanishi N, Hayashi YK, Taniguchi T, Miyagawa K, Hamaoka T, Maruyama N, Matoba S, Ikeda K, Yamada H, Oh H, Ueyama T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 111
Pages: 3811-3816
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] MURC/Cavin-4 Regulates Cardiac Function via β-adrenergic Receptor Signaling.2015
Author(s)
2.Hamaoka T, Ogata T, Naito D, Nakanishi N, Miyagawa K, Maruyama N, Kasahara T, Nishi M, Shirayama T, Ueyama T.
Organizer
American Heart Association Scientific Session 2015
Place of Presentation
Orlando, USA
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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