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Fabrication of a human iPSC-derived cardiac tissue using 3D bioprinter

Research Project

Project/Area Number 26670410
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionKeio University

Principal Investigator

Tohyama Shugo  慶應義塾大学, 医学部, 助教 (90528192)

Co-Investigator(Kenkyū-buntansha) Fujita Jun  慶應義塾大学, 医学部(信濃町), 特任講師 (10306706)
Nakamura Makoto  富山大学, 大学院理工学研究部(工学), 教授 (90301803)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsヒトiPS細胞 / 心筋細胞 / 血管内皮細胞 / 3Dプリンター / スキャフォールド / 3Dプリンター / 内皮細胞 / 3Dプリンター / 3次元構築
Outline of Final Research Achievements

Human iPSCs are one of the most attractive cell sources for regenerative medicine. Although many challenges have been overcome for clinical application, establishment of optimal method for transplantation is an unsolved problem. In this study, we aimed to fabricate a human iPSC-derived aligned cardiac tissue with . At first, we have built a grid-like gel scaffold using the 3D bioprinter. Thereafter, we seeded cardiomyocytes and fabricated a mesh-like aligned cardiac tissue. This mesh-like aligned cardiac tissue is expected to be utilized for part of large cardiac tissue or for a tool of drug screening.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 6 results)

  • [Journal Article] Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.2016

    • Author(s)
      Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K.
    • Journal Title

      Cell Metab

      Volume: 23 Issue: 4 Pages: 663-74

    • DOI

      10.1016/j.cmet.2016.03.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A massive suspension culture system with metabolic purification for human pluripotent stem cell-derived cardiomyocytes.2014

    • Author(s)
      Hemmi N**, Tohyama S**, Nakajima K, Kanazawa H, Suzuki T, Hattori F, Seki T, Kishino Y, Hirano A, Okada M, Tabei R, Ohno R, Fujita C, Haruna T, Yuasa S, Sano M, Fujita J, Fukuda K.
    • Journal Title

      Stem Cells Translational Medicine

      Volume: 3 Issue: 12 Pages: 1473-83

    • DOI

      10.5966/sctm.2014-0072

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 代謝制御によるヒトiPS細胞由来純化心筋細胞を用いた心筋球作製法の開発と再生医療への応用2016

    • Author(s)
      遠山周吾
    • Organizer
      第55回日本生体医工学会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 3Dプリンターを応用した配向する心筋組織作製2015

    • Author(s)
      塚本佳也,加藤陸,杉本和之,荒井健一,境慎司,遠山周吾,藤田淳,福田恵一,中村真人
    • Organizer
      平成27年度 日本生体医工学会 北陸支部
    • Place of Presentation
      富山駅前CiCビル(富山県富山市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 代謝制御を基盤とした心臓再生医療2015

    • Author(s)
      遠山周吾
    • Organizer
      第19回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 代謝的アプローチによるヒトES/iPS細胞を用いた心臓再生医療2015

    • Author(s)
      遠山周吾
    • Organizer
      第14回日本再生医療学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 多能性幹細胞の代謝と心臓再生医療2014

    • Author(s)
      遠山周吾
    • Organizer
      第18回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      横浜市開港記念会館
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Clinical Application of Induced Pluripotent Stem Cells for Heart Failure Treatment: Potentials, Progress, and Obstacles2014

    • Author(s)
      Jun Fujita
    • Organizer
      American Heart Association. Scientific Sessions 2014
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Current perspectives on cardiac regenerative therapy with human induced pluripotent stem cells2014

    • Author(s)
      藤田淳
    • Organizer
      第18回心不全学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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