Role of microvascular dysfunction in the cardiovascular center for development of hypertension
Project/Area Number |
26670413
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Shirai Mikiyasu 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (70162758)
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Co-Investigator(Kenkyū-buntansha) |
TSUCHIMOCHI HIROTSUGU 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (60379948)
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Co-Investigator(Renkei-kenkyūsha) |
INAGAKI TADAKATSU 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 (20638366)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 高血圧 / 交感神経活動 / 心臓血管中枢 / 延髄微小循環 / 高血圧自然発症ラット / 間歇的低酸素 / 肺循環 / 循環器・高血圧 / 肺交感神経活動 / 微小循環 |
Outline of Final Research Achievements |
We applied synchrotron radiation microangiography to young (4-week-old) spontaneously hypertensive rat (SHR) whose blood pressure is usually normal and found that arterioles in the medulla oblongata show abnormal responses (vasoconstriction) specifically with acute hypoxic exposure. In the unanesthetized young SHR, we measured renal and lumbar sympathetic nerve activity (SNA) for a month and found no significant SNA increase despite progressive rise in systemic blood pressure. In the chronic intermittent hypoxic rat, the SNA increased in proportion to blood pressure rise, but pulmonary SNA increase is not accompanied by pulmonary pressor response during acute hypoxic exposure. The inhibition of SNA increase with central β1 receptor blockade disclosed the hypoxic pulmonary pressor response, suggesting the SNA increase attenuates the hypoxic pulmonary response. These data suggest an important role of the ischemic state of the cardiovascular center for controlling SNA and blood pressure.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia2015
Author(s)
Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Sayoko Ogura, Takashi Sonobe, Tadakatsu Inagaki, Yutaka Fujii, Rutsuko Yamaguchi, Lisa Wingenfeld, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, Koichi Uemura, James T. Pearson, Mikiyasu Shirai
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Journal Title
PLoS ONE
Volume: 10
Issue: 7
Pages: 1-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension2015
Author(s)
Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, and Nakaoka Y
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: Early Edition
Issue: 20
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.2015
Author(s)
Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
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Journal Title
Dev Cell.
Volume: 33
Issue: 3
Pages: 247-259
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.2015
Author(s)
Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.
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Journal Title
Cardiovasc Diabetol
Volume: 14
Issue: 1
Pages: 92-105
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia2014
Author(s)
Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James Todd Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl Schwenke
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Journal Title
Basic Research in Cardiology
Volume: 109
Issue: 5
Pages: 432-432
DOI
Related Report
Peer Reviewed
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[Journal Article] Beta2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats2014
Author(s)
Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, James T. Pearson, Koichi Uemura, Mikiyasu Shirai
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Journal Title
PLOS ONE
Volume: 10
Issue: 10
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in young insulin resistant Goto-Kakizaki rats.2016
Author(s)
Perason J, Chen Y, Inagaki T, Fujii, Y, Schwenke D, Edgley A, Umetani K, Zhan Y, Yoshimoto M, Tsuchimochi H, Nagai H, Kuwahira I, Evans R, Shirai M.
Organizer
The 93rd Annual Meeting of the Physiological Society of Japan
Place of Presentation
Sapporo
Year and Date
2016-03-22
Related Report
Int'l Joint Research
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