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Development of molecular-targeting therapy against liver metastasis of small cell lung cancer

Research Project

Project/Area Number 26670418
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

NISHIOKA Yasuhiko  徳島大学, 大学院医歯薬学研究部(医学系), 教授 (70274199)

Co-Investigator(Kenkyū-buntansha) 柿内 聡司  徳島大学, 大学院医歯薬学研究部(医学系), 非常勤講師 (50380100)
後東 久嗣  徳島大学, 大学院医歯薬学研究部(医学系), 講師 (00437641)
Co-Investigator(Renkei-kenkyūsha) GOTO Hisatsugu  徳島大学, 大学院医歯薬学研究部, 講師 (00437641)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肝転移 / 小細胞肺癌 / 予後 / 肺癌 / 予後因子 / 分子標的治療
Outline of Final Research Achievements

In the present study, we examined the clinical significance of liver metastasis and identified the specific gene associated with liver metastasis in small cell lung cancer (SCLC). We first found the sphere-forming population of SCLC cell line SBC5 preferentially metastasized to the liver. Using these cell lines, the specific gene B associated with liver metastasis was identified. The knockdown of the gene B in SBC5 cells showed the reduction of metastasis to the liver, but not other organs. From the clinical analysis, we confirmed the association between liver metastasis and PS in SCLC patients.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (65 results)

All 2017 2016 2015 2014

All Journal Article (19 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 9 results,  Acknowledgement Compliant: 4 results) Presentation (45 results) (of which Int'l Joint Research: 4 results,  Invited: 9 results) Book (1 results)

  • [Journal Article] An analysis of the clinical features of lung cancer in patients with connective tissue diseases.2017

    • Author(s)
      Saijo A, Hanibuchi M, Goto H, Toyoda Y, Tezuka T, Nishioka Y.
    • Journal Title

      Respir Investig

      Volume: 55(2) Issue: 2 Pages: 153-160

    • DOI

      10.1016/j.resinv.2016.11.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of acute exacerbation of interstitial lung disease associated with chemotherapy in patients with lung cancer: a feasibility of S-1.2017

    • Author(s)
      Kakiuchi S, Hanibuchi M, Tezuka T, Saijo A, Otsuka K, Sakaguchi S, Toyoda Y, Goto H, Kawano H, Azuma M, Ogushi F, Nishioka Y.
    • Journal Title

      Respir Investig

      Volume: 55(2) Issue: 2 Pages: 145-152

    • DOI

      10.1016/j.resinv.2016.10.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer immunotherapy as a promising fourth standard therapy for lung cancer: Beyond 20 years for the development of immunotherapy.2016

    • Author(s)
      Nishioka Y
    • Journal Title

      Respir Investig

      Volume: 54(5) Issue: 5 Pages: 297-297

    • DOI

      10.1016/j.resinv.2016.08.001

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Analysis of the Prognostic Factors of Extensive Disease Small-Cell Lung Cancer Patients in Tokushima University Hospital.2016

    • Author(s)
      Ogino H, Hanibuchi M, Kakiuchi S, Saojo A, Tezuka T, Toyoda Y, Tobiume M, Otsuka K, Sakaguchi S, Goto H, Arisawa K, Nishioka Y.
    • Journal Title

      J Med Invest

      Volume: 63(3,4) Issue: 3.4 Pages: 286-293

    • DOI

      10.2152/jmi.63.286

    • NAID

      130005245830

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1.2016

    • Author(s)
      Hasegawa K, Tagawa M, Takagi K, Tsukamoto H, Tomioka Y, Suzuki T, Nishioka Y, Ohrui T, Numasaki M.
    • Journal Title

      Cancer Gene Ther

      Volume: 23(8) Issue: 8 Pages: 266-277

    • DOI

      10.1038/cgt.2016.29

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells2016

    • Author(s)
      Numasaki M, Tsukamoto H, Tomioka Y, Nishioka Y, Ohrui T.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 240 Issue: 1 Pages: 47-56

    • DOI

      10.1620/tjem.240.47

    • NAID

      130005261734

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antitumor effect of novel anti-podoplanin antibody NZ-12 against malignant pleural mesothelioma in an orthotopic xenograft model.2016

    • Author(s)
      Abe S, Kato KM, Tsuchihashi Y, Izumi T, Ogasawara S, Okada N, Sato C, Tobiume M, Otsuka K, Miyamoto L, Tsuchiya K, Kawazoe K, Kato Y, Nishioka Y.
    • Journal Title

      Cancer Sci

      Volume: 107(9) Issue: 9 Pages: 1198-1205

    • DOI

      10.1111/cas.12985

    • NAID

      120006535008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary Pulmonary Synovial Sarcoma Showing a Prolonged Survival with Multimodality Therapy2016

    • Author(s)
      Ogino H, Hanibuchi M, Takizawa H, Sakiyama S, Sumitomo H, Iwamoto S, Ikushima H, Nakajima K, Nagahiro H, Yamago T, Toyoda Y, Bando Y, Nishioka Y
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 4 Pages: 381-387

    • DOI

      10.2169/internalmedicine.55.5169

    • NAID

      130005125790

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 線維細胞がかかわる血管新生阻害薬に対する獲得耐性メカニズム2016

    • Author(s)
      後東久嗣,三橋敦志,西岡安彦
    • Journal Title

      分子呼吸器病

      Volume: 20(1) Pages: 111-114

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab2015

    • Author(s)
      Mitsuhashi A, Goto H, Saijo A, Trung VT, Aono Y, Ogino H, Kuramoto T, Tabata S, Uehara H, Izumi K, Yoshida M, Kobayashi H, Takahashi H, Gotoh M, Kakiuchi S, Hanibuchi M, Yano S, Yokomisa H, Sakiyama S, Nishioka Y
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8792-8792

    • DOI

      10.1038/ncomms9792

    • NAID

      120006999406

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pemetrexed-Induced Rash May Be Prevented by Supplementary Corticosteroids2015

    • Author(s)
      Takumi Sakurada, Soji Kakiuchi, Soichiro Tajima, Yuya Horinouchi, Ken Konaka, Naoto Okada, Hirotaka Nishisako, Toshimi Nakamura, Kazuhiko Teraoka, Kazuyoshi Kawazoe, Hiroaki Yanagawa, Yasuhiko Nishioka, Keisuke Ishizawa
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 11 Pages: 1752-1756

    • DOI

      10.1248/bpb.b15-00435

    • NAID

      130005106388

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity.2015

    • Author(s)
      Kato Y, Kunita A, Abe S, Ogasawara S, Fujii Y, Oki H, Fukayama M, Nishioka Y, Kaneko MK.
    • Journal Title

      Oncotarget.

      Volume: 6(34) Issue: 34 Pages: 36003-36018

    • DOI

      10.18632/oncotarget.5339

    • NAID

      120007120171

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Characteristics and risk factors of interstitial lung disease induced by chemotherapy for lung cancer2015

    • Author(s)
      Takumi Sakurada, Soji Kakiuchi, Soichiro Tajima, Yuya Horinouchi, Naoto Okada, Hirotaka Nishisako, Toshimi Nakamura, Kazuhiko Teraoka, Kazuyoshi Kawazoe, Hiroaki Yanagawa, Yasuhiko Nishioka, Kazuo Minakuchi, Keisuke Ishizawa
    • Journal Title

      The Annals Pharmacotherapy

      Volume: 49(4) Issue: 4 Pages: 398-404

    • DOI

      10.1177/1060028014566446

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice2015

    • Author(s)
      Seidai Sato, Yuka Kawamata, Akiko Takahashi, Yoshinori Imai, Aki Hanyu, Atsushi Okuma, Masaki Takasugi, Kimi Yamakoshi, Hiroyuki Sorimachi, Hiroaki Kanda, Yuichi Ishikawa, Saburo Sone, Yasuhiko Nishioka, Naoko Ohtani and Eiji Hara
    • Journal Title

      Nature communications

      Volume: 6 Issue: 1 Pages: 7035-7035

    • DOI

      10.1038/ncomms8035

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] New wave of immunotherapy against lung cancer rolls in to clinic2014

    • Author(s)
      Nishioka Y
    • Journal Title

      Transl Lung Cancer Res

      Volume: 3 Pages: 1-1

    • Related Report
      2014 Research-status Report
  • [Journal Article] Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes2014

    • Author(s)
      Matsuo T, Dat le T, Komatsu M, Yoshimaru T, Daizumoto K, Sone S, Nishioka Y, Katagiri T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e113606-e113606

    • DOI

      10.1371/journal.pone.0113606

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives2014

    • Author(s)
      Hanibuchi M, Kim SJ, Fidler IJ, Nishioka Y
    • Journal Title

      J Med Invest

      Volume: 61 Pages: 241-253

    • NAID

      130004822728

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of surfactant protein A in non-infectious lung diseases2014

    • Author(s)
      Goto H, Mitsuhashi A, Nishioka Y
    • Journal Title

      J Med Invest

      Volume: 61 Pages: 1-6

    • NAID

      130004822696

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新薬の最近の話題「デノスマブ」2014

    • Author(s)
      後東久嗣, 西岡安彦
    • Journal Title

      分子呼吸器病

      Volume: 18 Pages: 109-111

    • NAID

      40021326748

    • Related Report
      2014 Research-status Report
  • [Presentation] 腫瘍免疫学の基礎と肺癌免疫療法の歩み2016

    • Author(s)
      西岡安彦
    • Organizer
      第57回日本肺癌学会学術集会 シンポジウム13
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-12-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 当科における高齢者肺癌の若年者との比較検討2016

    • Author(s)
      埴淵昌毅,手塚敏史,西條敦郎,荻野広和,後東久嗣,西岡安彦
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-12-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] The mechanism of immunotherapy for lung cancer.2016

    • Author(s)
      Nishioka Y
    • Organizer
      第57回日本肺癌学会学術集会 JICS/KASLC symposium
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 悪性胸水を伴った非扁平上皮非小細胞肺癌に対する Bevacizumab 併用化学療法の検討2016

    • Author(s)
      西條敦郎,手塚敏史,荻野広和,豊田優子,後東久嗣,埴淵昌毅,西岡安彦
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 島大学病院における進展型小細胞肺癌患者の予後因子に関する後ろ向き研究2016

    • Author(s)
      荻野広和,後東久嗣,西條敦郎,柿内聡司,埴淵昌毅,西岡安彦
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 呼吸器疾患のトランスレーショナルリサーチ~アカデミア発の創薬を目指した多職種連携~2016

    • Author(s)
      西岡安彦
    • Organizer
      第64回医療薬学公開シンポジウム
    • Place of Presentation
      長井記念ホール(徳島県・徳島市)
    • Year and Date
      2016-11-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Aquired resistance to anti-angiogenic therapy and new insights toward the overcoming.2016

    • Author(s)
      Yasuhiko Nishioka
    • Organizer
      JASMO 2016 Annual Meeting(International Symposium 10)
    • Place of Presentation
      神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 徳島大学病院における進展型小細胞肺癌患者の予後因子についての検討2016

    • Author(s)
      荻野広和,埴淵 昌毅,大塚 憲司,西條 敦郎,坂口 暁,手塚 敏史,柿内 聡司,後東 久嗣,西岡 安彦
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小細胞肺癌における肝転移の位置づけとがん幹細胞様細胞の役割2016

    • Author(s)
      後東久嗣,荻野広和,三橋惇志,西岡安彦
    • Organizer
      第25回日本がん転移学会学術集会・総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県・米子市)
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺癌,悪性胸膜中皮腫に対する免疫チェックポイント阻害剤の有効性の基礎的検討2016

    • Author(s)
      大塚憲司,埴淵昌毅,荻野広和,後東久嗣,西岡安彦
    • Organizer
      第25回日本がん転移学会学術集会・総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県・米子市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨髄由来線維細胞(fibrocyte)は肺癌のがん幹細胞様特性を促進する2016

    • Author(s)
      西條敦郎,後東久嗣,三橋惇志,中野万有里,大塚憲司,荻野広和,坂口暁,埴淵昌毅,西岡安彦
    • Organizer
      第25回日本がん転移学会学術集会・総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県・米子市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 受容体型チロシンキナーゼROR2は悪性胸膜中皮腫細胞の増殖を制御する2016

    • Author(s)
      荻野広和,後東久嗣,西條敦郎,大塚憲司,埴淵昌毅,西岡安彦
    • Organizer
      第25回日本がん転移学会学術集会・総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県・米子市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺がんに対する血管新生阻害薬の耐性機構とその克服2016

    • Author(s)
      西岡安彦
    • Organizer
      第176回日本肺癌学会関東支部学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ポドプラニンを標的とした抗体療法とペメトレキセドの併用による悪性胸膜中皮腫に対する抗腫瘍効果の検討2016

    • Author(s)
      阿部真治,加藤幸成,後東久嗣,埴淵昌毅,西岡安彦
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター(大分県・別府市)
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] Receptor tyrosine kinase-like orphan receptor 2, ROR2, regulates the proliferation of malignant pleural mesothelioma cells.2016

    • Author(s)
      Ogino H, Goto H, Kakiuchi S, Saijo A, Sakaguchi A, Tobiume M, Otsuka K, Hanibuchi M, Nishioka Y.
    • Organizer
      ATS 2016 International Conference
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bone marrow-derived fibrocytes maintain stem cell-like properties of lung cancer.2016

    • Author(s)
      Saijo A, Goto H, Mitsuhashi A, Nakano M, Ogino H, Aono Y, Sakaguchi S, Tobiume M, Otsuka K, Hanibuchi M, Nishioka Y.
    • Organizer
      ATS 2016 International Conference
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fibrocytes mediate acquired resistance to anti-angiogenic therapy with bevacizumab in thoracic tumors.2016

    • Author(s)
      Goto H, Mitsuhashi A, Saijo A, Kuramoto T, Tabata T, Aono Y, Uehara H, Hanibuchi M, Nishioka Y.
    • Organizer
      ATS 2016 International Conference
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢者進行非小細胞肺癌患者を対象としてPRO評価を取り入れたS-1療法の臨床第Ⅱ相試験2016

    • Author(s)
      荻野広和,後東久嗣,大串文隆,葉久貴司,兼松貴則,浦田知之,埴淵昌毅,曽根三郎,西岡安彦
    • Organizer
      第113回日本内科学会総会・講演会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of fibrocytes and growth factors in lung fibrosis and cancer.2016

    • Author(s)
      西岡安彦
    • Organizer
      第56回日本呼吸器学会学術講演会(Inter-Assembly Symposium 2)
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2016-04-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 悪性胸膜中皮腫に対する新規抗ポドプラニン抗体NE-12の効果2016

    • Author(s)
      阿部真治,加藤幸成,金子美華,後東久嗣,埴淵昌毅,西岡安彦
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん免疫のABC:肺がんに対する免疫療法の理解に向けて.2015

    • Author(s)
      西岡安彦
    • Organizer
      第56回日本肺癌学会学術集会(シンポジウム).
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 癌患者血漿中遊離DNAを用いた遺伝子変異検査技術の比較.2015

    • Author(s)
      埴淵昌毅、加納 亮、倉本卓哉、後東久嗣、坂口 暁、豊田優子、手塚敏史、西條敦郎、西岡安彦.
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 当院における膠原病に合併した肺癌の検討. .2015

    • Author(s)
      西條敦郎、坂口 暁、手塚敏史、柿内聡司、豊田優子、後東久嗣、埴淵昌毅、西岡安彦.
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Sphere 形成癌幹細胞様分画のヒト肺癌多臓器転移モデルマウスにおける役割についての解析.2015

    • Author(s)
      荻野広和, 三橋惇志, 後東久嗣, 西條敦郎, 佐藤正大, 坂口暁, 手塚敏史, 倉本卓哉, 田畑祥, 上原久典, 埴淵昌毅, 西岡安彦.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規ヒトキメラ型抗ポドプラニン抗体 NZ-12 の悪性胸膜中皮腫に対する抗腫瘍効果.2015

    • Author(s)
      阿部真治, 加藤幸成, 金子美華, 大塚憲司, 後東久嗣, 埴淵昌毅, 西岡安彦.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Mechanisms of acquired resistance to anti-angiogenic therapy and new insights toward the overcoming.2015

    • Author(s)
      Yasuhiko Nishioka, Hisatsugu Goto.
    • Organizer
      第74回日本癌学会学術総会 (Core Symposia 2).
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Fibrocyte はがん幹細胞性維持により肺癌進展を促進する2015

    • Author(s)
      西條敦郎, 後東久嗣, 三橋惇志, 中野万有里, 山子泰斗, 坂口暁, 柿内聡司, 埴淵昌毅, 西岡安彦.
    • Organizer
      第24回日本がん転移学会学術集会・総会
    • Place of Presentation
      シティプラザ大阪(大阪府・大阪市)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Sphere 形成癌幹細胞様分画の肺癌多臓器転移における役割についての解析.2015

    • Author(s)
      荻野広和, 後東久嗣, 三橋惇志, 西條敦郎, 佐藤正大, 柿内聡司, 埴淵昌毅, 上原久典, 西岡安彦.
    • Organizer
      第24回日本がん転移学会学術集会・総会
    • Place of Presentation
      シティプラザ大阪(大阪府・大阪市)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 肺癌に対する抗PD-L1抗体治療の基礎的検討.2015

    • Author(s)
      大塚憲司, 埴淵昌毅, 後東久嗣, 西岡安彦.
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル(愛媛県・松山市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 線維細胞(fibrocytes)が関わる血管新生阻害剤に対する獲得耐性メカニズム2015

    • Author(s)
      三橋惇志, 後東久嗣, 西條敦郎, 埴淵昌毅, 西岡安彦.
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山全日空ホテル(愛媛県・松山市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Characterization of Sphere-Forming Stem-Like Population of Lung Cancer Cell Line in Multi-Organ Metastasis Model2015

    • Author(s)
      Hirokazu Ogino, Atsushi Mitsuhashi, Hisatsugu Goto, Atsuro Saijo, Takuya Kuramoto, Sho Tabata, Hisanori Uehara, Soji Kakiuchi, Masaki Hanibuchi, Yasuhiko Nishioka
    • Organizer
      ATS 2015 International Conference
    • Place of Presentation
      デンバー(USA)
    • Year and Date
      2015-05-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fibrocytes mediate acquired resistance to anti-angiogenic therapy with bevacizumab.2015

    • Author(s)
      Hisatsugu Goto, Atsushi Mitsuhashi, Atsuro Saijo, Takuya Kuramoto, Sho Tabata, Yoshinori Aono, Soji Kakiuchi, Masaki Hanibuchi, Yasuhiko Nishioka.
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京・千代田区)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規分子標的薬とそのターゲット2015

    • Author(s)
      西岡安彦
    • Organizer
      第55回日本呼吸器学会学術講演会(教育講演)
    • Place of Presentation
      東京国際フォーラム(東京・千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 当院における間質性肺炎合併肺癌の治療の現状2015

    • Author(s)
      柿内聡司, 荻野広和, 大塚憲司, 坂口暁, 西條敦郎, 後東久嗣, 埴淵昌毅, 西岡安彦.
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京・千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] がん免疫療法の過去と未来:エビデンスが示した新たな可能性2014

    • Author(s)
      西岡安彦
    • Organizer
      第62回日本口腔学会 中国・四国地方部会(招待講演)
    • Place of Presentation
      徳島大学歯学部大講義室(徳島県・徳島市)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] ベバシズマブに対する獲得耐性メカニズムとしての線維細胞(fibrocytes)の役割2014

    • Author(s)
      後東久嗣, 三橋惇志, 西條敦郎, 柿内聡司, 埴淵昌毅, 上原久典, 矢野聖二, 西岡安彦
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] がん特異的抗ポドプラニン抗体の樹立2014

    • Author(s)
      加藤幸成, 金子美華, 小笠原諭, 西岡安彦
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 血小板凝集因子Podoplaninに対するがん特異的抗体の開発2014

    • Author(s)
      加藤幸成, 西岡安彦
    • Organizer
      第23回日本がん転移学会学術集会
    • Place of Presentation
      金沢市文化ホール(石川県・金沢市)
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺癌多臓器転移モデルにおけるsphere形成癌幹細胞様分画の役割2014

    • Author(s)
      後東久嗣, 三橋惇志, 倉本卓哉, 田畑祥, 西條敦郎, 柿内聡司, 埴淵昌毅, 上原久典, 西岡安彦
    • Organizer
      第23回日本がん転移学会学術集会
    • Place of Presentation
      金沢市文化ホール(石川県・金沢市)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト小細胞肺癌骨転移に対するRANKL標的治療におけるIGF-1の関与2014

    • Author(s)
      山子泰斗, 後東久嗣, 三橋惇志, 倉本卓哉, 田畑祥, 西條敦郎, 柿内聡司, 埴淵昌毅, 小川博久, 上原久典, 西岡安彦
    • Organizer
      第23回日本がん転移学会学術集会
    • Place of Presentation
      金沢市文化ホール(石川県・金沢市)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ベバシズマブに対する獲得耐性メカニズムとしての線維細胞(fibrocytes)の役割2014

    • Author(s)
      後東久嗣, 三橋惇志, 西條敦郎, 倉本卓哉, 田畑祥, 埴淵昌毅, 柿内聡司, 青野純典, 上原久典, 西岡安彦
    • Organizer
      第18回日本がん分子標的治療学会学術集会(招待講演)
    • Place of Presentation
      仙台市情報・産業プラザ(宮城県・仙台市)
    • Year and Date
      2014-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 胸膜中皮腫同所移植モデルにおける抗ポドプラニン抗体の抗腫瘍効果2014

    • Author(s)
      大塚憲司, 阿部真治, 埴淵昌毅, 木宿昌俊, 川添和義, 加藤幸成, 西岡安彦
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市情報・産業プラザ(宮城県・仙台市)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of fibrocytes in the resistance to anti-angiogenic therapy in malignant pleural mesothelioma and lung cancer2014

    • Author(s)
      Hisatsugu Goto, Atsushi Mitsuhashi, Atsuro Saijo, Trung The Van, Yoshinori Aono, Hirohisa Ogawa, Soji Kakiuchi, Masaki Hanibuchi, Seiji Yano, Keisuke Izumi, Yasuhiko Nishioka
    • Organizer
      ATS 2014 International Conference
    • Place of Presentation
      San Diego (U.S.A)
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺がん・中皮腫における血管新生阻害薬耐性2014

    • Author(s)
      西岡安彦
    • Organizer
      第54回日本呼吸器学会学術講演会(招待講演)
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院における間質性肺炎合併肺癌の治療の現状2014

    • Author(s)
      柿内聡司, 大塚憲司, 佐藤正大, 西條敦郎, 坂口暁, 後東久嗣, 埴淵昌毅, 西岡安彦
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Book] 今日の診療のために ガイドライン外来診療20152015

    • Author(s)
      西岡安彦、加藤広行、中島政信、高橋雅一、滝沢耕平、坂本一博、波多野悦朗、上本紳二、清水 怜、塩谷彰浩、賀本敏行、池田伊知郎、神野浩光、北川雄光、齋藤 豪、寺本瑞絵他
    • Total Pages
      694
    • Publisher
      日経メディカル開発
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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