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Induction of tolerance in the airways by extracellular ATP

Research Project

Project/Area Number 26670420
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKitasato University (2015)
Keio University (2014)

Principal Investigator

Suzuki Yusuke  北里大学, 北里研究所病院, 部長(医師) (80306696)

Co-Investigator(Renkei-kenkyūsha) KUBO Akiharu  慶應義塾大学, 医学部, 専任講師 (70335256)
KAWASAKI Hiroshi  慶應義塾大学, 医学部, 特任助教 (70445344)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords免疫寛容 / 免疫寛容の誘導
Outline of Final Research Achievements

Our animal experiments indicated amelioration of allergic airway inflammation after skin injury, which was opposite to commonsense. Thus we hypothesized that skin injury induced an allergy-protecting factor.
We assumed the factor would be ATP and administrated ATP directly on animal skin. However, it turned out to be ineffective. We are seeking another candidate factor by analyzing injured skin tissue with DNA microarray.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2015

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens2015

    • Author(s)
      Ogawa R, Suzuki Y, Kagawa S, Masaki K, Fukunaga K, Yoshimura A, Fujishima S, Terashima T, Betsuyaku T, Asano K
    • Journal Title

      Allergology International

      Volume: 64 Issue: Supplement.1 Pages: 24-29

    • DOI

      10.1016/j.alit.2015.04.005

    • NAID

      130005099477

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotype of asthma related with high serum periostin levels2015

    • Author(s)
      Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 2 Pages: 175-180

    • DOI

      10.1016/j.alit.2014.07.003

    • NAID

      130005290305

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] バリア機能の破綻とアレルギー2015

    • Author(s)
      鈴木雄介、浅野浩一郎
    • Journal Title

      アレルギー

      Volume: 64 Pages: 1297-1304

    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺気腫マウスモデルを用いた真菌誘導性好酸球性炎症の末梢気腔増大に与える影響2015

    • Author(s)
      田野崎貴絵、福永興壱、高橋左枝子、加川志津子、加畑宏樹、持丸貴生、松坂雅子、正木克宜、大塚健悟、鎌谷高志、上田壮一郎、鈴木雄介、別役智子
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 真菌誘導性好酸球性炎症の肺気腫マウスモデルにおける末梢気腔増大に与える影響2015

    • Author(s)
      田野崎貴絵、福永興壱、高橋左枝子、加川志津子、加畑宏樹、持丸貴生、松坂雅子、正木克宜、大塚健悟、鎌谷高志、上田壮一郎、鈴木雄介、別役智子
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 真菌抗原感作が重症喘息に与える影響2015

    • Author(s)
      正木克宜、福永興壱、鎌谷高志、大塚健悟、田野崎貴絵、松坂雅子、持丸貴生、加畑宏樹、上田壮一郎、鈴木雄介、中村守男、小山田吉孝、井上卓、梅田啓、浅野浩一郎、別役智子
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Group2 innate lymphoid cell (ILC2) 抑制による新規喘息治療薬の探索2015

    • Author(s)
      松坂雅子、福永興壱、加畑宏樹、加川志津子、正木克宜、持丸貴生、田野崎貴絵、大塚健悟、鎌谷高志、上田壮一郎、鈴木雄介、田中健一郎、水島徹、別役智子
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 卵白アルブミン(OVA)喘息マウスモデルにおけるエイコサペンタエン酸(EPA)代謝産物の有用性の検討2015

    • Author(s)
      持丸貴生、福永興壱、宮田純、松坂雅子、正木克宜、田野崎貴絵、大塚健悟、上田壮一郎、加川志津子、加畑宏樹、鈴木雄介、磯部洋輔、有田誠、別役智子
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 重症喘息患者における診断時年齢がアドヒアランスに与える影響2015

    • Author(s)
      鎌谷高志、正木克宜、福永興壱、大塚健悟、田野崎貴絵、松坂雅子、持丸貴生、加畑宏樹、上田壮一郎、加行淳子、黄英文、鈴木雄介、佐山宏一、坂巻文雄、浅野浩一郎、別役智子
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tape Stripping Reduces Airway Eosinophilic Inflammation in a Murine Asthma Model2015

    • Author(s)
      Yusuke Suzuki
    • Organizer
      AAAAI 2015 Annual Meeting
    • Place of Presentation
      Houston, TX, USA
    • Year and Date
      2015-02-20 – 2015-02-24
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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