| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We investigated the effect of renal congestion on the renal function and renal injury in rats. Renal venous congestion decreased urinary flow and glomerular filtration ratio. These results indicate that the renal congestion could cause the further accumulation of body fluid, and form a vicious cycle. Renal congestion also induced renal interstitial fibrosis, tubular injury and inflammation in the chronic phase. The renal interstitial hydrostatic pressure could contribute to these renal injury. Diuretics attenuated renal injury induced by renal congestion in some part.
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